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Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives
Li, Zhi1,2; Yan, Chao3; Lv, Qin-yu4; Yi, Zheng-hui4; Zhang, Jian-ye5; Wang, Jin-hong5; Lui, Simon S. Y.6; Xu, Yi-feng4; Cheung, Eric F. C.6; Gur, Raquel E.7; Gur, Ruben C.7; Chan, Raymond C. K.1,2
First AuthorZhi Li
2018-05-01
Source PublicationSCHIZOPHRENIA RESEARCH
Correspondent Emailrckchan@psych.ac.cn (r.c.k. chan)
ISSN0920-9964
Volume195Pages:215-221
Abstract

Despite empirical findings showing that patients with schizophrenia and their unaffected first-degree relatives have deficits in processing monetary incentives, it is unclear whether similar deficits could be demonstrated for affective incentives. Twenty-six patients with schizophrenia and 26 age and gender matched healthy controls; 23 unaffected first-degree relatives and 23 matched healthy controls were recruited to complete a Monetary Incentive Delay (MID) task and an Affective Incentive Delay (AID) task in a 3-Tesla MRI scanner. Hypoactivation in the dorsal striatum when anticipating monetary incentives were found in patients with schizophrenia and their unaffected first-degree relatives compared with healthy controls. Furthermore, patients with schizophrenia showed hyperactivation in the ventral striatum when receiving both monetary and affective incentives. These findings suggest that disorganized striatal function, regardless of incentive types, may be present in patients with schizophrenia and before the onset of illness in their first-degree unaffected relatives. (C) 2017 Elsevier B.V. All rights reserved.

KeywordSchizophrenia First-degree Relative Dopamine Neural Circuits
DOI10.1016/j.schres.2017.08.043
Language英语
Funding OrganizationNational Science Fund China ; National Basic Research Program of China (Precision Psychiatry Programme) ; Beijing Municipal Science & Technology Commission Grant ; Beijing Training Project for Leading Talents in ST
Funding ProjectNational Science Fund China[81571317] ; National Science Fund China[31500894] ; National Basic Research Program of China (Precision Psychiatry Programme)[2016YFC0906402] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000432466700031
PublisherELSEVIER SCIENCE BV
WOS KeywordReward Anticipation ; Dorsal Striatum ; Linking Biology ; Activation ; Dopamine ; Prediction ; Psychosis ; Salience ; Phenomenology ; Dissociation
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26503
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.East China Normal Univ, Sch Psychol & Cognit Sci, Key Lab Brain Funct Genom MOE & STCSM, Shanghai, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
5.Shanghai Mental Hlth Ctr, MRI Ctr, Shanghai, Peoples R China
6.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
7.Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
Recommended Citation
GB/T 7714
Li, Zhi,Yan, Chao,Lv, Qin-yu,et al. Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives[J]. SCHIZOPHRENIA RESEARCH,2018,195:215-221.
APA Li, Zhi.,Yan, Chao.,Lv, Qin-yu.,Yi, Zheng-hui.,Zhang, Jian-ye.,...&Chan, Raymond C. K..(2018).Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives.SCHIZOPHRENIA RESEARCH,195,215-221.
MLA Li, Zhi,et al."Striatal dysfunction in patients with schizophrenia and their unaffected first-degree relatives".SCHIZOPHRENIA RESEARCH 195(2018):215-221.
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