Theory of mind deficits partly mediate impaired social decision-making in schizophrenia

doi:10.1186/s12888-017-1313-3

PSYCH OpenIR

	Theory of mind deficits partly mediate impaired social decision-making in schizophrenia
	Yang,Liuqing 1,2,3; Li,Peifu 4; Mao,Haiying 4; Wang,Huiling 4; Shu,Chang 4; Bliksted,Vibeke 5,6; Zhou,Yuan 1,2
摘要	AbstractBackgroundUsing paradigms from game theory, researchers have reported abnormal decision-making in social context in patients with schizophrenia. However, less is known about the underpinnings of the impairment. This study aimed to test whether theory of mind (ToM) deficits and/or neurocognitive dysfunctions mediate impaired social decision-making in patients with schizophrenia.MethodsWe compared thirty-five patients with schizophrenia to thirty-eight matched healthy controls with regard to social decision-making using the mini Ultimatum Game (mini UG), a paradigm from game theory. Additionally, we assessed ToM using the Theory of Mind Picture Stories Task, a mental state attribution task, and assessed neurocognition using the Brief Assessment of Cognition in Schizophrenia. Mediation analyses were performed on the data.ResultsIn contrast to the behavioral pattern of healthy controls in the mini UG, the patients with schizophrenia significantly accepted more disadvantageous offers and rejected?more advantageous offers, and showed reduced sensitivity to the fairness-related context changes in the mini UG. Impaired ToM and neurocognition were also found in the patients. Mediation analyses indicated that ToM but not neurocognition partially mediated the group differences on the disadvantageous and advantageous offers in the mini UG.ConclusionsPatients with schizophrenia exhibited impaired social decision-making. This impairment can be partly explained by their ToM deficits rather than neurocognitive deficits. However, the exact nature of the ToM deficits that mediate impaired social decision-making needs to be identified in future.
关键词	Social decision-making Theory of mind Neurocognition Schizophrenia Mini ultimatum game
	2017-5-5
语种	en
DOI	10.1186/s12888-017-1313-3
发表期刊	BMC Psychiatry
ISSN	1471-244X
卷号	17 期号:1
出版者	BioMed Central
WOS记录号	BMC:10.1186/s12888-017-1313-3
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/26513
通讯作者	Zhou,Yuan
作者单位	1.CAS Key Laboratory of Behavioral Science, Institute of Psychology 2.University of Chinese Academy of Sciences; Department of Psychology 3.Sino-Danish Center for Education and Research 4.Renmin Hospital of Wuhan University; Department of Psychiatry 5.Aarhus University Hospital Risskov, Psychosis Research Department 6.Aarhus University, Interacting Minds Centre
推荐引用方式 GB/T 7714	Yang,Liuqing,Li,Peifu,Mao,Haiying,et al. Theory of mind deficits partly mediate impaired social decision-making in schizophrenia[J]. BMC Psychiatry,2017,17(1).
APA	Yang,Liuqing.,Li,Peifu.,Mao,Haiying.,Wang,Huiling.,Shu,Chang.,...&Zhou,Yuan.(2017).Theory of mind deficits partly mediate impaired social decision-making in schizophrenia.BMC Psychiatry,17(1).
MLA	Yang,Liuqing,et al."Theory of mind deficits partly mediate impaired social decision-making in schizophrenia".BMC Psychiatry 17.1(2017).