PSYCH OpenIR  > 中国科学院心理健康重点实验室
Neurological and Neuropsychological Endophenotypes in Schizophrenia Spectrum Disorders
Raymond C.K. Chan; William S. Stone; Xiaolu Hsi
First AuthorRaymond C.K. Chan
Correspondent Emailrckchan@psych.ac.cn; rckchan2003@yahoo.com.hk
Abstract

Increasing efforts to identify alternate expressions of mental disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of psychiatric disorders may advance the search for underlying etiological or modulatory factors. These alternate phenotypes or “endophenotypes” (e.g., social, psychophysiological or neuropsychological abnormalities) of disorders may be more specific and amenable to objective measurement than clinical symptoms, which presumably reflects variation among smaller numbers of genes than more distal clinical symptoms. These features support the current usefulness of endophenotypes in genetic studies, and their potential usefulness in the development of strategies for early intervention. In this chapter, we review potential neurological and neuropsychological endophenotypes for schizophrenia and for schizophrenia spectrum disorders, with an emphasis on key conceptual criteria for assessing endophenotypes, including their relationships to schizophrenia, to non-psychotic relatives, and to heritability. Future directions for establishing the validity of endophenotype research are also discussed.

KeywordEndophenotypes Neurological Makers Behavioral Markers Schizophrenia
2011
Language英语
Source PublicationHandbook of Schizophrenia Spectrum Disorders
Volume2Issue:不详Pages:325-349
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26530
Collection中国科学院心理健康重点实验室
脑与认知科学国家重点实验室
AffiliationNeuropsychology and Applied Cognitive Neuroscience Laboratory, Beijing, China; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Recommended Citation
GB/T 7714
Raymond C.K. Chan,William S. Stone,Xiaolu Hsi. Neurological and Neuropsychological Endophenotypes in Schizophrenia Spectrum Disorders[J]. Handbook of Schizophrenia Spectrum Disorders,2011,2(不详):325-349.
APA Raymond C.K. Chan,William S. Stone,&Xiaolu Hsi.(2011).Neurological and Neuropsychological Endophenotypes in Schizophrenia Spectrum Disorders.Handbook of Schizophrenia Spectrum Disorders,2(不详),325-349.
MLA Raymond C.K. Chan,et al."Neurological and Neuropsychological Endophenotypes in Schizophrenia Spectrum Disorders".Handbook of Schizophrenia Spectrum Disorders 2.不详(2011):325-349.
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