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Oxytocin Modulates Semantic Integration in Speech Comprehension
Zheng Ye1,2; Arjen Stolk1; Ivan Toni1; Peter Hagoort1,3
第一作者Zheng Ye
2017-02
发表期刊JOURNAL OF COGNITIVE NEUROSCIENCE
通讯作者邮箱yez@psych.ac.cn ; peter.hagoort@donders.ru.nl
ISSN0898-929X
文章类型Article
卷号29期号:2页码:267-276
摘要

Listeners interpret utterances by integrating information from multiple sources including word level semantics and world knowledge. When the semantics of an expression is inconsistent with their knowledge about the world, the listener may have to search through the conceptual space for alternative possible world scenarios that can make the expression more acceptable. Such cognitive exploration requires considerable computational resources and might depend on motivational factors. This study explores whether and how oxytocin, a neuropeptide known to influence social motivation by reducing social anxiety and enhancing affiliative tendencies, can modulate the integration of world knowledge and sentence meanings. The study used a between-participant double-blind randomized placebo-controlled design. Semantic integration, indexed with magnetoencephalography through the N400m marker, was quantified while 45 healthy male participants listened to sentences that were either congruent or incongruent with facts of the world, after receiving intranasally delivered oxytocin or placebo. Compared with congruent sentences, world knowledge incongruent sentences elicited a stronger N400m signal from the left inferior frontal and anterior temporal regions and medial pFC (the N400m effect) in the placebo group. Oxytocin administration significantly attenuated the N400m effect at both sensor and cortical source levels throughout the experiment, in a state-like manner. Additional electrophysiological markers suggest that the absence of the N400m effect in the oxytocin group is unlikely due to the lack of early sensory or semantic processing or a general downregulation of attention. These findings suggest that oxytocin drives listeners to resolve challenges of semantic integration, possibly by promoting the cognitive exploration of alternative possible world scenarios.

关键词Social Cognition Language Comprehension Sentence Comprehension World Knowledge Behavior Meg Responses Context Empathy Stress
DOI10.1162/jocn_a_01044
收录类别SCIE
语种英语
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26548
专题健康与遗传心理学研究室
作者单位1.Radboud University Nijmegen
2.Chinese Academy of Sciences
3.Max Planck Institute for Psycholinguistics
推荐引用方式
GB/T 7714
Zheng Ye,Arjen Stolk,Ivan Toni,et al. Oxytocin Modulates Semantic Integration in Speech Comprehension[J]. JOURNAL OF COGNITIVE NEUROSCIENCE,2017,29(2):267-276.
APA Zheng Ye,Arjen Stolk,Ivan Toni,&Peter Hagoort.(2017).Oxytocin Modulates Semantic Integration in Speech Comprehension.JOURNAL OF COGNITIVE NEUROSCIENCE,29(2),267-276.
MLA Zheng Ye,et al."Oxytocin Modulates Semantic Integration in Speech Comprehension".JOURNAL OF COGNITIVE NEUROSCIENCE 29.2(2017):267-276.
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