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Placebo Analgesia in Rodents
Jian-You Guo; Jin-Yan Wang; Fei Luo
专著(文集)名Placebo and Pain From Bench to Bedside
2014
15-23
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出版地不详
关键词Placebo Analgesia Rodents Morphine Antidepressant Opioid Receptor Pros Cons
英文摘要

The placebo effect is a fascinating yet puzzling phenomenon which has challenged investigators over the past 50 years. Some researchers have initiated investigations of the effects of placebos in animals, and have shown that associative learning is a major way to elicit placebo responses. Pain is the field in which most of the placebo research has been performed. In contrast to numerous studies involving human subjects, the available literature on placebo-induced analgesia in animal models is rare. This chapter introduces a special drug-conditioning procedure, a cue paired with morphine or aspirin, eliciting analgesic responses in a hot plate test. This established placebo analgesia was considered to be transferable from pain to depression and could produce a significant antidepressant effect in a test on depression in mice. Furthermore, the opioid placebo analgesia was found to be mediated exclusively through a μ-opioid receptor in the rat. The pros and cons of studying placebo in animal models are also discussed at the end of this chapter.

语种英语
文献类型专著章节, 文集论文
条目标识符http://ir.psych.ac.cn/handle/311026/26551
专题中国科学院心理健康重点实验室
作者单位Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, P. R. China
推荐引用方式
GB/T 7714
Jian-You Guo,Jin-Yan Wang,Fei Luo. Placebo Analgesia in Rodents. 2014.
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