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Subtenon Injection of Triamcinolone Acetonide Inhibits Expression of Inflammatory Mediators in Laser Photocoagulation Treated Rats with Diabetic Retinopathy
Li, S (Li, Shuang)1; Wang, YL (Wang, Yanling)1; Li, N (Li, Na)1; Lin, PY (Lin, Pengyao)1; Li, Q (Li, Qian)1; Yu, SJ (Yu, Shujing)1; Luo, LH (Luo, Lihua)1; Guo, JY (Guo, Jianyou)2; Wang, K (Wang, Kang)1
第一作者Li, S (Li, Shuang)
2016-03
发表期刊JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
通讯作者邮箱wang, k
文章类型Article
卷号6期号:4页码:316-322
摘要

This study is aimed to investigate the effects of subtenon injection of triamcinolone acetonide (TA) on expression of inflammatory mediators and retinal thickness in diabetic rats after laser panretinal photocoagulation (PRP) treatment. Diabetes was induced in male Brown-Norway rats that were subjected to PRP treatment with or without TA injection and sacrificed on day 1, 3 and 7 post PRR. Untreated healthy rats were used as controls. The diabetic rats showed significantly increased retinal thickness compared with those healthy controls as measured by optical coherence tomography. The retinal thickness in diabetic rats on day 3 post PRP was higher than in those controls without PRP treatment. And a significant reduction of retinal thickness in diabetic rats with TA injection was observed 7 days after PRR. Expression of vascular endothelial growth factor (VEGF), IL-6 and tumor necrosis factor alpha (TNF-alpha) was upregulated in diabetic rats and PRP treatment did not have a significant impact on expression of these genes. However, subtenon injection of TA reduced expression of VEGF, IL-6 and TNF-alpha regardless of PRP treatment. The results suggest that TA injection effectively reduce the retinal thickness caused by diabetes and PRP, and inhibite the expression of inflammatory mediators in diabetic rats with or without PRP treatment.

关键词Diabetic Retinopathy Macular Edema Retinal Inflammation Panretinal Photocoagulation Triamcinolone Acetonide
DOI10.1166/jbt.2016.1442
语种英语
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26588
专题中国科学院心理健康重点实验室
作者单位1.Beijing Capital Med Univ, Affiliated Beijing Friendship Hosp, Dept Ophthalmol, Beijing 100050, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100050, Peoples R China
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GB/T 7714
Li, S ,Wang, YL ,Li, N ,et al. Subtenon Injection of Triamcinolone Acetonide Inhibits Expression of Inflammatory Mediators in Laser Photocoagulation Treated Rats with Diabetic Retinopathy[J]. JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,2016,6(4):316-322.
APA Li, S .,Wang, YL .,Li, N .,Lin, PY .,Li, Q .,...&Wang, K .(2016).Subtenon Injection of Triamcinolone Acetonide Inhibits Expression of Inflammatory Mediators in Laser Photocoagulation Treated Rats with Diabetic Retinopathy.JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,6(4),316-322.
MLA Li, S ,et al."Subtenon Injection of Triamcinolone Acetonide Inhibits Expression of Inflammatory Mediators in Laser Photocoagulation Treated Rats with Diabetic Retinopathy".JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 6.4(2016):316-322.
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