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Subtenon Injection of Triamcinolone Acetonide Inhibits Expression of Inflammatory Mediators in Laser Photocoagulation Treated Rats with Diabetic Retinopathy
Li, S (Li, Shuang)1; Wang, YL (Wang, Yanling)1; Li, N (Li, Na)1; Lin, PY (Lin, Pengyao)1; Li, Q (Li, Qian)1; Yu, SJ (Yu, Shujing)1; Luo, LH (Luo, Lihua)1; Guo, JY (Guo, Jianyou)2; Wang, K (Wang, Kang)1
First AuthorLi, S (Li, Shuang)
2016-03
Source PublicationJOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
Correspondent Emailwang, k
SubtypeArticle
Volume6Issue:4Pages:316-322
Abstract

This study is aimed to investigate the effects of subtenon injection of triamcinolone acetonide (TA) on expression of inflammatory mediators and retinal thickness in diabetic rats after laser panretinal photocoagulation (PRP) treatment. Diabetes was induced in male Brown-Norway rats that were subjected to PRP treatment with or without TA injection and sacrificed on day 1, 3 and 7 post PRR. Untreated healthy rats were used as controls. The diabetic rats showed significantly increased retinal thickness compared with those healthy controls as measured by optical coherence tomography. The retinal thickness in diabetic rats on day 3 post PRP was higher than in those controls without PRP treatment. And a significant reduction of retinal thickness in diabetic rats with TA injection was observed 7 days after PRR. Expression of vascular endothelial growth factor (VEGF), IL-6 and tumor necrosis factor alpha (TNF-alpha) was upregulated in diabetic rats and PRP treatment did not have a significant impact on expression of these genes. However, subtenon injection of TA reduced expression of VEGF, IL-6 and TNF-alpha regardless of PRP treatment. The results suggest that TA injection effectively reduce the retinal thickness caused by diabetes and PRP, and inhibite the expression of inflammatory mediators in diabetic rats with or without PRP treatment.

KeywordDiabetic Retinopathy Macular Edema Retinal Inflammation Panretinal Photocoagulation Triamcinolone Acetonide
DOI10.1166/jbt.2016.1442
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26588
Collection中国科学院心理健康重点实验室
Affiliation1.Beijing Capital Med Univ, Affiliated Beijing Friendship Hosp, Dept Ophthalmol, Beijing 100050, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100050, Peoples R China
Recommended Citation
GB/T 7714
Li, S ,Wang, YL ,Li, N ,et al. Subtenon Injection of Triamcinolone Acetonide Inhibits Expression of Inflammatory Mediators in Laser Photocoagulation Treated Rats with Diabetic Retinopathy[J]. JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,2016,6(4):316-322.
APA Li, S .,Wang, YL .,Li, N .,Lin, PY .,Li, Q .,...&Wang, K .(2016).Subtenon Injection of Triamcinolone Acetonide Inhibits Expression of Inflammatory Mediators in Laser Photocoagulation Treated Rats with Diabetic Retinopathy.JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,6(4),316-322.
MLA Li, S ,et al."Subtenon Injection of Triamcinolone Acetonide Inhibits Expression of Inflammatory Mediators in Laser Photocoagulation Treated Rats with Diabetic Retinopathy".JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 6.4(2016):316-322.
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