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Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry
Levran, O (Levran, Orna)1,2; Peles, E (Peles, Einat)2,3; Randesi, M (Randesi, Matthew)1; da Rosa, JC (da Rosa, Joel Correa)4; Ott, J (Ott, Jurg)5,6; Rotrosen, J (Rotrosen, John)7; Rotrosen, J (Rotrosen, John)1,2,8; Kreek, MJ (Kreek, Mary Jeanne)1
第一作者Levran, O (Levran, Orna)
2015-11
会议名称不详
通讯作者邮箱levrano@rockefeller.edu
会议录名称CNS NEUROSCIENCE & THERAPEUTICS
卷号21
期号11
页码898-904
会议日期不详
会议地点不详
摘要

AimDrug addiction is characterized, in part, by deregulation of synaptic plasticity in circuits involved in reward, stress, cue learning, and memory. This study was designed to assess whether 185 variants in 32 genes central to synaptic plasticity and signal transduction contribute to vulnerability to develop heroin and/or cocaine addiction. 

MethodsAnalyses were conducted in a sample of 1860 subjects divided according to ancestry (African and European) and drug of abuse (heroin or cocaine). 

ResultsEighteen SNPs in 11 genes (CDK5R1, EPHA4, EPHA6, FOSL2, MAPK3, MBP, MPDZ, NFKB1, NTRK2, NTSR1, and PRKCE) showed significant associations (P < 0.01), but the signals did not survive correction for multiple testing. SNP rs230530 in the NFKB1 gene, encoding the transcription regulator NF-kappa-B, was the only SNP indicated in both ancestry groups and both addictions. This SNP was previously identified in association with alcohol addiction. SNP rs3915568 in NTSR1, which encodes neurotensin receptor, and SNP rs1389752 in MPDZ, which encodes the multiple PDZ domain protein, were previously associated with heroin addiction or alcohol addiction, respectively. 

ConclusionsThe study supports the involvement of genetic variation in signal transduction pathways in heroin and cocaine addiction and provides preliminary evidence suggesting several new risk or protective loci that may be relevant for diagnosis and treatment success.

关键词African Americans Cocaine Addiction Heroin Addiction Signal Transduction Synaptic Plasticity
DOI10.1111/cns.12450
语种英语
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被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型会议论文
条目标识符http://ir.psych.ac.cn/handle/311026/26591
专题健康与遗传心理学研究室
作者单位1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA
2.Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Tel Aviv, Israel
3.Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
4.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA
5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China
6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA
7.VA New York Harbor Healthcare Syst, Sch Med, New York, NY USA
8.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV USA
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Levran, O ,Peles, E ,Randesi, M ,et al. Synaptic Plasticity and Signal Transduction Gene Polymorphisms and Vulnerability to Drug Addictions in Populations of European or African Ancestry[C],2015:898-904.
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