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Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia
Shihao Wu1; Huiling Wang1,2; Cheng Chen1; Jilin Zou1; Huan Huang1; Peifu Li1; Yilin Zhao3; Qizhong Xu3; Liang Zhang3; Hesheng Wang1; Sanjib Pandit1; Subodh Dahal1; Jun Chen3; Yuan Zhou4,5; Tianzi Jiang6,7; Gaohua Wang1,8,9
First AuthorShihao Wu
2017-02
Source PublicationFRONTIERS IN PSYCHOLOGY
Correspondent Emailzhouyuan@psych.ac.cn ; wgh6402@163.com
SubtypeArticle
Volume8Issue:不详Pages:1-14
Abstract

 

Previous studies have suggested that patients with schizophrenia and healthy controls exhibit differential activation of and connectivity involving the dorsolateral prefrontal cortex (DLPFC) during working memory tasks, though their findings remain inconsistent. The functional integration perspective further suggests that working memory performance also modulates differences in functional interactions of the DLPFC between patients and controls. To explore this possibility, 45 healthy controls and 45 patients with schizophrenia were recruited to perform a 2-back task during functional magnetic resonance imaging (fMRI). Each group was further divided into two subgroups based on task performance to examine the modulatory effect of performance on functional interactions of the DLPFC, as measured via psychophysiological interaction (PPI) analyses. We observed that, in patients with schizophrenia who exhibited impaired working memory capacity and decreased brain activation/deactivation, functional interactions between the right/left DLPFC and angular cortex were decreased relative to those of healthy controls. Furthermore, we observed an interaction effect of working memory performance and diagnosis on functional connectivity between the right/left DLPFC seed region and posterior regions such as the angular cortex, fusiform gyrus, and middle occipital gyrus. This interaction effect was mainly driven by the negative correlation between functional connectivity and performance in healthy controls, and by the positive correlation in patients with schizophrenia. These results demonstrate the effects of inter-individual differences in working memory performance on functional interactions between the DLPFC and posterior regions in patients with schizophrenia as well as healthy controls, which may shed new light on the neural basis of working memory.

KeywordSchizophrenia N-back Fmri Psychophysiological Interaction (Ppi) Middle Frontal Gyrus Fusiform Gyrus Inferior Parietal Lobule (Ipl)
DOI10.3389/fpsyg.2017.00056
Language英语
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26594
Collection中国科学院行为科学重点实验室
Affiliation1.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan, Peoples R China
2.Hubei Prov Key Lab Dev Originated Dis, Wuhan, Peoples R China
3.Wuhan Univ, Dept Radiol, Renmin Hosp, Wuhan, Peoples R China
4.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automatuon, Brainnetome Ctr, Beijing, Peoples R China
7.Minist Educ, Sch Life Sci & Technol China, Key Lab NeuroInformat, Chengdu, Peoples R China
8.Hubei Inst Neurol & Psychiat Res, Wuhan, Peoples R China
9.Hubei Univ Sci & Technol, Xianning, Peoples R China
Recommended Citation
GB/T 7714
Shihao Wu,Huiling Wang,Cheng Chen,et al. Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia[J]. FRONTIERS IN PSYCHOLOGY,2017,8(不详):1-14.
APA Shihao Wu.,Huiling Wang.,Cheng Chen.,Jilin Zou.,Huan Huang.,...&Gaohua Wang.(2017).Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia.FRONTIERS IN PSYCHOLOGY,8(不详),1-14.
MLA Shihao Wu,et al."Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia".FRONTIERS IN PSYCHOLOGY 8.不详(2017):1-14.
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