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Transcriptome Sequencing Reveals Candidate NF-kappa B Target Genes Involved in Repeated Cocaine Administration
Wang, Yan1,2; Teng, Huajing2,3; Sapozhnikov, Daniel M.4; Du, Quansheng5; Zhao, Mei1,2
First AuthorYan Wang
2018-07-01
Source PublicationINTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
Correspondent Emailzhaomei@psych.ac.cn
ISSN1461-1457
Volume21Issue:7Pages:697-704
Abstract

Background: Drug-induced alterations in gene expression play an important role in the development of addictive behavior. Numerous transcription factors have been implicated in mediating the gene expression changes that occur in drug addiction. Nuclear factor kappa B is an inducible transcription factor complex that is rapidly activated by diverse stimuli. Methods: We performed next-generation high-throughput sequencing of the prefrontal cortex in a mouse model of repeated cocaine administration combined with pharmacological nuclear factor kappa B inhibition to identify nuclear factor kappa B target genes that participate in the cocaine addiction process. Results: We found that the nuclear factor kappa B antagonist sodium diethyldithiocarbamate trihydrate significantly reversed the cocaine-induced expression changes of the amphetamine addiction pathway. Genes that demonstrated differential expression in response to cocaine treatment that was also reversed by sodium diethyldithiocarbamate trihydrate were enriched for the axon guidance pathway. Furthermore, the nuclear factor kappa B homo-dimer motif could be mapped to 86 of these sodium diethyldithiocarbamate trihydrate-reversed genes, which were also enriched for axon guidance. Conclusions: We suggest that nuclear factor kappa B directly modifies the expression of axon guidance pathway members, leading to cocaine sensitization. Our findings reveal the role of prefrontal cortex nuclear factor kappa B activity in addiction and uncover the molecular mechanisms by which nuclear factor kappa B drives changes in the addicted brain.

KeywordAddiction Cocaine Nuclear Factor Kappa b Prefrontal Cortex Sodium Diethyldithiocarbamate Trihydrate
DOI10.1093/ijnp/pyy031
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Funding ProjectNational Natural Science Foundation of China[91132728] ; National Natural Science Foundation of China[30870821] ; National Natural Science Foundation of China[61401459] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000440972100009
PublisherOXFORD UNIV PRESS
WOS KeywordCircadian Genes ; Expression ; Incubation ; Addiction ; Proteins ; Amygdala ; Therapy ; Reward ; Brain ; Mouse
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26690
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhao, Mei
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China
4.McGill Univ Montreal, Dept Pharmacol & Therapeut, Montreal, PQ, Canada
5.Natl Nat Sci Fdn China, Dept Life Sci, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Wang, Yan,Teng, Huajing,Sapozhnikov, Daniel M.,et al. Transcriptome Sequencing Reveals Candidate NF-kappa B Target Genes Involved in Repeated Cocaine Administration[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2018,21(7):697-704.
APA Wang, Yan,Teng, Huajing,Sapozhnikov, Daniel M.,Du, Quansheng,&Zhao, Mei.(2018).Transcriptome Sequencing Reveals Candidate NF-kappa B Target Genes Involved in Repeated Cocaine Administration.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,21(7),697-704.
MLA Wang, Yan,et al."Transcriptome Sequencing Reveals Candidate NF-kappa B Target Genes Involved in Repeated Cocaine Administration".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 21.7(2018):697-704.
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