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Transcriptome Sequencing Reveals Candidate NF-kappa B Target Genes Involved in Repeated Cocaine Administration
Wang, Yan1,2; Teng, Huajing2,3; Sapozhnikov, Daniel M.4; Du, Quansheng5; Zhao, Mei1,2
2018-07-01
发表期刊INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
ISSN1461-1457
卷号21期号:7页码:697-704
摘要Background: Drug-induced alterations in gene expression play an important role in the development of addictive behavior. Numerous transcription factors have been implicated in mediating the gene expression changes that occur in drug addiction. Nuclear factor kappa B is an inducible transcription factor complex that is rapidly activated by diverse stimuli. Methods: We performed next-generation high-throughput sequencing of the prefrontal cortex in a mouse model of repeated cocaine administration combined with pharmacological nuclear factor kappa B inhibition to identify nuclear factor kappa B target genes that participate in the cocaine addiction process. Results: We found that the nuclear factor kappa B antagonist sodium diethyldithiocarbamate trihydrate significantly reversed the cocaine-induced expression changes of the amphetamine addiction pathway. Genes that demonstrated differential expression in response to cocaine treatment that was also reversed by sodium diethyldithiocarbamate trihydrate were enriched for the axon guidance pathway. Furthermore, the nuclear factor kappa B homo-dimer motif could be mapped to 86 of these sodium diethyldithiocarbamate trihydrate-reversed genes, which were also enriched for axon guidance. Conclusions: We suggest that nuclear factor kappa B directly modifies the expression of axon guidance pathway members, leading to cocaine sensitization. Our findings reveal the role of prefrontal cortex nuclear factor kappa B activity in addiction and uncover the molecular mechanisms by which nuclear factor kappa B drives changes in the addicted brain.
关键词addiction cocaine nuclear factor kappa B prefrontal cortex sodium diethyldithiocarbamate trihydrate
DOI10.1093/ijnp/pyy031
语种英语
项目资助者National Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
资助项目National Natural Science Foundation of China[91132728] ; National Natural Science Foundation of China[30870821] ; National Natural Science Foundation of China[61401459] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000440972100009
出版者OXFORD UNIV PRESS
关键词[WOS]CIRCADIAN GENES ; EXPRESSION ; INCUBATION ; ADDICTION ; PROTEINS ; AMYGDALA ; THERAPY ; REWARD ; BRAIN ; MOUSE
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26690
专题中国科学院心理健康重点实验室
通讯作者Zhao, Mei
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China
4.McGill Univ Montreal, Dept Pharmacol & Therapeut, Montreal, PQ, Canada
5.Natl Nat Sci Fdn China, Dept Life Sci, Beijing, Peoples R China
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Wang, Yan,Teng, Huajing,Sapozhnikov, Daniel M.,et al. Transcriptome Sequencing Reveals Candidate NF-kappa B Target Genes Involved in Repeated Cocaine Administration[J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,2018,21(7):697-704.
APA Wang, Yan,Teng, Huajing,Sapozhnikov, Daniel M.,Du, Quansheng,&Zhao, Mei.(2018).Transcriptome Sequencing Reveals Candidate NF-kappa B Target Genes Involved in Repeated Cocaine Administration.INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY,21(7),697-704.
MLA Wang, Yan,et al."Transcriptome Sequencing Reveals Candidate NF-kappa B Target Genes Involved in Repeated Cocaine Administration".INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 21.7(2018):697-704.
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