Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study

doi:10.1002/pchj.227

PSYCH OpenIR

	Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study
	Zhou, Han-yu 1,2,3; Li, Zhi 1,2; Xie, Dong-jie 1,2; Xu, Ting 4,5,6; Cheung, Eric E. F.7; Li, Huanhuan 3; Chan, Raymond C. K.1,2
摘要	Impairments in spatial working memory (SWM) and set-shifting abilities have both been consistently observed in individuals with schizophrenia and are considered to be potential endophenotypes of this illness. However, an endophenotype needs to fulfill a set of stringent criteria, including heritability. This study examined the heritability of these two functions in a healthy Chinese twin sample. Forty-five pairs of monozygotic (MZ) twins and 35 pairs of dizygotic (DZ) twins completed the SWM task and the Intra-Extra Dimensional Set-Shifting (IED) task of the Cambridge Neuropsychological Test Automated Battery (CANTAB). We found a moderate heritability for SWM, of which the familial/genetic factors accounted for 33% of the total variance. However, we failed to find any significant heritability for set-shifting ability, of which the specific environmental factor explained most of the variance (85%). The preliminary findings from this small healthy Chinese twin sample suggest that SWM is heritable, whereas the set-shifting ability may reflect extra-genetic influences.
关键词	endophenotype heritability set-shifting spatial working memory twins design
	2018-09-01
语种	英语
DOI	10.1002/pchj.227
发表期刊	PSYCH JOURNAL
ISSN	2046-0252
卷号	7 期号:3 页码:144-151
资助项目	CAS Key Laboratory of Mental Health, Institute of Psychology ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology
出版者	WILEY
WOS关键词	1ST-EPISODE SCHIZOPHRENIA ; NEUROCOGNITIVE ENDOPHENOTYPES ; EXECUTIVE DYSFUNCTION ; ONSET SCHIZOPHRENIA ; HIGH-RISK ; RELATIVES ; DEFICITS ; ABILITY ; PHENOTYPES ; PSYCHOSIS
WOS研究方向	Psychology
WOS类目	Psychology, Multidisciplinary
WOS记录号	WOS:000443584400004
资助机构	Beijing Municipal Science & Technology Commission ; Beijing Training Project for Leading Talents in ST ; CAS Key Laboratory of Mental Health, Institute of Psychology
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/26834
通讯作者	Chan, Raymond C. K.
作者单位	1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Renmin Univ China, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Key Lab Behav Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 6.Child Mind Inst, Ctr Developing Brain, New York, NY USA 7.Castle Peak Hosp, Tuen Mun, Hong Kong, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Han-yu,Li, Zhi,Xie, Dong-jie,et al. Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study[J]. PSYCH JOURNAL,2018,7(3):144-151.
APA	Zhou, Han-yu.,Li, Zhi.,Xie, Dong-jie.,Xu, Ting.,Cheung, Eric E. F..,...&Chan, Raymond C. K..(2018).Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study.PSYCH JOURNAL,7(3),144-151.
MLA	Zhou, Han-yu,et al."Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study".PSYCH JOURNAL 7.3(2018):144-151.