Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI

doi:10.1093/cercor/bhx179

PSYCH OpenIR

	Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI
	Schaefer, Alexander 1,2; Kong, Ru 1,2; Gordon, Evan M.3; Laumann, Timothy O.4; Zuo, Xi-Nian 5,6; Holmes, Avram J.7; Eickhoff, Simon B.8,9; Thomas, B. T.1,2,10,11
摘要	A central goal in systems neuroscience is the parcellation of the cerebral cortex into discrete neurobiological "atoms". Resting state functional magnetic resonance imaging (rs-fMRI) offers the possibility of in vivo human cortical parcellation. Almost all previous parcellations relied on 1 of 2 approaches. The local gradient approach detects abrupt transitions in functional connectivity patterns. These transitions potentially reflect cortical areal boundaries defined by histology or visuotopic fMRI. By contrast, the global similarity approach clusters similar functional connectivity patterns regardless of spatial proximity, resulting in parcels with homogeneous (similar) rs-fMRI signals. Here, we propose a gradient-weighted Markov Random Field (gwMRF) model integrating local gradient and global similarity approaches. Using task-fMRI and rs-fMRI across diverse acquisition protocols, we found gwMRF parcellations to be more homogeneous than 4 previously published parcellations. Furthermore, gwMRF parcellations agreed with the boundaries of certain cortical areas defined using histology and visuotopic fMRI. Some parcels captured subareal (somatotopic and visuotopic) features that likely reflect distinct computational units within known cortical areas. These results suggest that gwMRF parcellations reveal neurobiologically meaningful features of brain organization and are potentially useful for future applications requiring dimensionality reduction of voxel-wise fMRI data. Multiresolution parcellations generated from 1489 participants are publicly available (https://github.com/ThomasYeoLab/CBIG/ tree/master/stable_projects/brain_parcellation/Schaefer2018_LocalGlobal).
关键词	brain parcellation Brodmann areas cytoarchitecture resting-state functional connectivity retinotopy
	2018-09-01
语种	英语
DOI	10.1093/cercor/bhx179
发表期刊	CEREBRAL CORTEX
ISSN	1047-3211
卷号	28 期号:9 页码:3095-3114
资助项目	Singapore Ministry of Education (MOE)[MOE2014-T2-2-016] ; National University of Singapore (NUS) Strategic Research[DPRT/944/09/14] ; NUS School of Medicine (SOM) Aspiration Fund[R185000271720] ; Singapore National Medical Research Council[CBRG/0088/2015] ; NUS Young Investigator Award ; Singapore National Research Foundation (NRF) ; DAAD postdoctoral fellowship ; NIMH[MH100872] ; NIMH[K01MH099232] ; National Basic Research (973) Program[2015CB351702] ; Natural Science Foundation of China[81 471 740] ; Natural Science Foundation of China[81220108014] ; Center for Functional Neuroimaging Technologies[P41EB015896] ; Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital[S10RR023401] ; Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital[S10RR023043] ; Human Connectome Project, WU-Minn Consortium[1U54MH091657] ; McDonnell Center for Systems Neuroscience at Washington University ; Singapore Ministry of Education (MOE)[MOE2014-T2-2-016] ; National University of Singapore (NUS) Strategic Research[DPRT/944/09/14] ; NUS School of Medicine (SOM) Aspiration Fund[R185000271720] ; Singapore National Medical Research Council[CBRG/0088/2015] ; NUS Young Investigator Award ; Singapore National Research Foundation (NRF) ; DAAD postdoctoral fellowship ; NIMH[MH100872] ; NIMH[K01MH099232] ; National Basic Research (973) Program[2015CB351702] ; Natural Science Foundation of China[81 471 740] ; Natural Science Foundation of China[81220108014] ; Center for Functional Neuroimaging Technologies[P41EB015896] ; Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital[S10RR023401] ; Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital[S10RR023043] ; Human Connectome Project, WU-Minn Consortium[1U54MH091657] ; McDonnell Center for Systems Neuroscience at Washington University
出版者	OXFORD UNIV PRESS INC
WOS关键词	RESTING-STATE FMRI ; INDEPENDENT COMPONENT ANALYSIS ; HUMAN CONNECTOME PROJECT ; PRIMARY MOTOR CORTEX ; VISUAL AREA MT ; HUMAN BRAIN ; LIFE-SPAN ; NETWORK ANALYSIS ; INDIVIDUAL-DIFFERENCES ; ASSOCIATION NETWORKS
WOS研究方向	Neurosciences & Neurology
WOS类目	Neurosciences
WOS记录号	WOS:000443545600003
资助机构	Singapore Ministry of Education (MOE) ; National University of Singapore (NUS) Strategic Research ; NUS School of Medicine (SOM) Aspiration Fund ; Singapore National Medical Research Council ; NUS Young Investigator Award ; Singapore National Research Foundation (NRF) ; DAAD postdoctoral fellowship ; NIMH ; National Basic Research (973) Program ; Natural Science Foundation of China ; Center for Functional Neuroimaging Technologies ; Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital ; Human Connectome Project, WU-Minn Consortium ; McDonnell Center for Systems Neuroscience at Washington University
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/26874
通讯作者	Thomas, B. T.
作者单位	1.Natl Univ Singapore, Singapore Inst Neurotechnol, ASTAR NUS Clin Imaging Res Ctr, Dept Elect & Comp Engn, Singapore, Singapore 2.Natl Univ Singapore, Memory Networks Program, Singapore, Singapore 3.VISN 17 Ctr Excellence Res Returning War Vet, Waco, TX USA 4.Washington Univ, Dept Neurol, St Louis, MO USA 5.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Yale Univ, New Haven, CT USA 8.Heinrich Heine Univ Dusseldorf, Fac Med, Inst Syst Neurosci, Dusseldorf, Germany 9.Res Ctr Julich, Inst Neurosci & Med Brain & Behav INM 7, Julich, Germany 10.Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA 11.Duke NUS Med Sch, Ctr Cognit Neurosci, Singapore, Singapore
推荐引用方式 GB/T 7714	Schaefer, Alexander,Kong, Ru,Gordon, Evan M.,et al. Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI[J]. CEREBRAL CORTEX,2018,28(9):3095-3114.
APA	Schaefer, Alexander.,Kong, Ru.,Gordon, Evan M..,Laumann, Timothy O..,Zuo, Xi-Nian.,...&Thomas, B. T..(2018).Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI.CEREBRAL CORTEX,28(9),3095-3114.
MLA	Schaefer, Alexander,et al."Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI".CEREBRAL CORTEX 28.9(2018):3095-3114.