Institutional Repository of Key Laboratory of Mental Health, CAS
Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study | |
Zhou, Han-yu1,2,3; Li, Zhi1,2; Xie, Dong-jie1,2; Xu, Ting4,5,6; Cheung, Eric E. F.7; Li, Huanhuan3; Chan, Raymond C. K.1,2 | |
第一作者 | Han-yu Zhou |
通讯作者邮箱 | rckchan@psych.ac.cn |
摘要 | Impairments in spatial working memory (SWM) and set-shifting abilities have both been consistently observed in individuals with schizophrenia and are considered to be potential endophenotypes of this illness. However, an endophenotype needs to fulfill a set of stringent criteria, including heritability. This study examined the heritability of these two functions in a healthy Chinese twin sample. Forty-five pairs of monozygotic (MZ) twins and 35 pairs of dizygotic (DZ) twins completed the SWM task and the Intra-Extra Dimensional Set-Shifting (IED) task of the Cambridge Neuropsychological Test Automated Battery (CANTAB). We found a moderate heritability for SWM, of which the familial/genetic factors accounted for 33% of the total variance. However, we failed to find any significant heritability for set-shifting ability, of which the specific environmental factor explained most of the variance (85%). The preliminary findings from this small healthy Chinese twin sample suggest that SWM is heritable, whereas the set-shifting ability may reflect extra-genetic influences. |
关键词 | Endophenotype Heritability Set-shifting Spatial Working Memory Twins Design |
2018-09-01 | |
语种 | 英语 |
DOI | 10.1002/pchj.227 |
发表期刊 | PSYCH JOURNAL |
ISSN | 2046-0252 |
卷号 | 7期号:3页码:144-151 |
资助项目 | Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology |
出版者 | WILEY |
WOS关键词 | 1st-episode Schizophrenia ; Neurocognitive Endophenotypes ; Executive Dysfunction ; Onset Schizophrenia ; High-risk ; Relatives ; Deficits ; Ability ; Phenotypes ; Psychosis |
WOS研究方向 | Psychology |
WOS类目 | Psychology, Multidisciplinary |
WOS记录号 | WOS:000443584400004 |
资助机构 | Beijing Municipal Science & Technology Commission ; Beijing Training Project for Leading Talents in ST ; CAS Key Laboratory of Mental Health, Institute of Psychology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/26892 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K. |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Renmin Univ China, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Key Lab Behav Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 6.Child Mind Inst, Ctr Developing Brain, New York, NY USA 7.Castle Peak Hosp, Tuen Mun, Hong Kong, Peoples R China |
第一作者单位 | 认知与发展心理学研究室 |
通讯作者单位 | 认知与发展心理学研究室 |
推荐引用方式 GB/T 7714 | Zhou, Han-yu,Li, Zhi,Xie, Dong-jie,et al. Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study[J]. PSYCH JOURNAL,2018,7(3):144-151. |
APA | Zhou, Han-yu.,Li, Zhi.,Xie, Dong-jie.,Xu, Ting.,Cheung, Eric E. F..,...&Chan, Raymond C. K..(2018).Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study.PSYCH JOURNAL,7(3),144-151. |
MLA | Zhou, Han-yu,et al."Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study".PSYCH JOURNAL 7.3(2018):144-151. |
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