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Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study
Zhou, Han-yu1,2,3; Li, Zhi1,2; Xie, Dong-jie1,2; Xu, Ting4,5,6; Cheung, Eric E. F.7; Li, Huanhuan3; Chan, Raymond C. K.1,2
第一作者Han-yu Zhou
2018-09-01
发表期刊PSYCH JOURNAL
通讯作者邮箱rckchan@psych.ac.cn
ISSN2046-0252
卷号7期号:3页码:144-151
摘要

Impairments in spatial working memory (SWM) and set-shifting abilities have both been consistently observed in individuals with schizophrenia and are considered to be potential endophenotypes of this illness. However, an endophenotype needs to fulfill a set of stringent criteria, including heritability. This study examined the heritability of these two functions in a healthy Chinese twin sample. Forty-five pairs of monozygotic (MZ) twins and 35 pairs of dizygotic (DZ) twins completed the SWM task and the Intra-Extra Dimensional Set-Shifting (IED) task of the Cambridge Neuropsychological Test Automated Battery (CANTAB). We found a moderate heritability for SWM, of which the familial/genetic factors accounted for 33% of the total variance. However, we failed to find any significant heritability for set-shifting ability, of which the specific environmental factor explained most of the variance (85%). The preliminary findings from this small healthy Chinese twin sample suggest that SWM is heritable, whereas the set-shifting ability may reflect extra-genetic influences.

关键词Endophenotype Heritability Set-shifting Spatial Working Memory Twins Design
DOI10.1002/pchj.227
语种英语
项目资助者Beijing Municipal Science & Technology Commission ; Beijing Training Project for Leading Talents in ST ; CAS Key Laboratory of Mental Health, Institute of Psychology
资助项目Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Psychology
WOS类目Psychology, Multidisciplinary
WOS记录号WOS:000443584400004
出版者WILEY
关键词[WOS]1st-episode Schizophrenia ; Neurocognitive Endophenotypes ; Executive Dysfunction ; Onset Schizophrenia ; High-risk ; Relatives ; Deficits ; Ability ; Phenotypes ; Psychosis
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26892
专题中国科学院心理健康重点实验室
通讯作者Chan, Raymond C. K.
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Renmin Univ China, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Key Lab Behav Sci, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China
6.Child Mind Inst, Ctr Developing Brain, New York, NY USA
7.Castle Peak Hosp, Tuen Mun, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Han-yu,Li, Zhi,Xie, Dong-jie,et al. Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study[J]. PSYCH JOURNAL,2018,7(3):144-151.
APA Zhou, Han-yu.,Li, Zhi.,Xie, Dong-jie.,Xu, Ting.,Cheung, Eric E. F..,...&Chan, Raymond C. K..(2018).Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study.PSYCH JOURNAL,7(3),144-151.
MLA Zhou, Han-yu,et al."Heritability estimates of spatial working memory and set-shifting in a healthy Chinese twin sample: A preliminary study".PSYCH JOURNAL 7.3(2018):144-151.
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