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Improving Motivation Through Real-Time fMRI-Based Self-Regulation of the Nucleus Accumbens
Li, Zhi1,2; Zhang, Chen-yuan1; Huang, Jia1,2; Wang, Yi1,2; Yan, Chao3; Li, Ke4; Zeng, Ya-wei4; Jin, Zhen4; Cheung, Eric F. C.5; Su, Li6; Chan, Raymond C. K.1,2
2018-09-01
发表期刊NEUROPSYCHOLOGY
ISSN0894-4105
卷号32期号:6页码:764-776
摘要

Objective: Impaired nucleus accumbens (NAcc) activation is associated with amotivation and anhedonia, which are resistant to treatment with antipsychotics and antidepressants in schizophrenia. In this study, healthy participants were trained to self-regulate the activation of their NAcc, a brain region that plays an important role in motivation, using real-time functional magnetic resonance imaging (fMRI) neurofeedback. Method: The experimental group (N = 19) received feedback from the NAcc, whereas the control group (N = 5) received "sham" feedback from the posterior parahippocampal gyrus, a control brain region not normally related to motivation. All participants were trained to use mental strategies to regulate their NAcc activations in a 3T MRI scanner. Results: For the learning effect of NAcc regulation, we found that the majority of participants (74%) in the experimental group successfully learned to self-regulate the NAcc. They also showed improved behavioral performance in motivation and decreased functional connectivity between the NAcc and the ventral medial prefrontal cortex and an increase in small-world properties in the reward circuit after training, indicating improved information integration in reward processing. However, improvement in motivation and modification of function connectivity were not observed in the sham control group and the participants who failed to self-regulate the NAcc in the experimental group. Self-regulation was influenced by the baseline motivation. Conclusions: These findings suggest that the NAcc could be self-regulated using real-time fMRI neurofeedback and can result in improved motivation in cognitive tasks.

关键词Real-time Fmri Nucleus Accumbens Motivation Generalization Effect Reward
DOI10.1037/neu0000425
语种英语
项目资助者National Natural Science Fund China ; Beijing Training Project for the Leading Talents in Science Technology ; Beijing Municipal Science & Technology Commission ; Chinese Academy of Sciences ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; CAS/SAFEA International Partnership Programme for Creative Research Teams ; NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia, at Cambridge University Hospitals NHS Foundation Trust ; University of Cambridge ; Alzheimer's Research UK
资助项目National Natural Science Fund China[91132701] ; National Natural Science Fund China[81571317] ; Beijing Training Project for the Leading Talents in Science Technology[Z151100000315020] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Chinese Academy of Sciences[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; CAS/SAFEA International Partnership Programme for Creative Research Teams[Y2CX131003] ; NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia, at Cambridge University Hospitals NHS Foundation Trust ; University of Cambridge ; Alzheimer's Research UK
WOS研究方向Psychology ; Neurosciences & Neurology
WOS类目Psychology, Clinical ; Neurosciences ; Psychology
WOS记录号WOS:000443739600012
出版者AMER PSYCHOLOGICAL ASSOC
关键词[WOS]Striatal Reward Prediction ; Incentive Salience ; Major Depression ; Anterior Insula ; Cue-reactivity ; Brain Activity ; Neurofeedback ; Schizophrenia ; Anhedonia ; Dysfunction
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26952
专题中国科学院心理健康重点实验室
通讯作者Su, Li; Chan, Raymond C. K.
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.East China Normal Univ, Sch Psychol & Cognit Sci, Key Lab Brain Funct Genom MOE & STCSM, Shanghai, Peoples R China
4.Hosp 306, MRI Ctr, Beijing, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
6.Univ Cambridge, Dept Psychiat, Cambridge, England
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Li, Zhi,Zhang, Chen-yuan,Huang, Jia,et al. Improving Motivation Through Real-Time fMRI-Based Self-Regulation of the Nucleus Accumbens[J]. NEUROPSYCHOLOGY,2018,32(6):764-776.
APA Li, Zhi.,Zhang, Chen-yuan.,Huang, Jia.,Wang, Yi.,Yan, Chao.,...&Chan, Raymond C. K..(2018).Improving Motivation Through Real-Time fMRI-Based Self-Regulation of the Nucleus Accumbens.NEUROPSYCHOLOGY,32(6),764-776.
MLA Li, Zhi,et al."Improving Motivation Through Real-Time fMRI-Based Self-Regulation of the Nucleus Accumbens".NEUROPSYCHOLOGY 32.6(2018):764-776.
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