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Improving Motivation Through Real-Time fMRI-Based Self-Regulation of the Nucleus Accumbens
Li, Zhi1,2; Zhang, Chen-yuan1; Huang, Jia1,2; Wang, Yi1,2; Yan, Chao3; Li, Ke4; Zeng, Ya-wei4; Jin, Zhen4; Cheung, Eric F. C.5; Su, Li6; Chan, Raymond C. K.1,2

Objective: Impaired nucleus accumbens (NAcc) activation is associated with amotivation and anhedonia, which are resistant to treatment with antipsychotics and antidepressants in schizophrenia. In this study, healthy participants were trained to self-regulate the activation of their NAcc, a brain region that plays an important role in motivation, using real-time functional magnetic resonance imaging (fMRI) neurofeedback. Method: The experimental group (N = 19) received feedback from the NAcc, whereas the control group (N = 5) received "sham" feedback from the posterior parahippocampal gyrus, a control brain region not normally related to motivation. All participants were trained to use mental strategies to regulate their NAcc activations in a 3T MRI scanner. Results: For the learning effect of NAcc regulation, we found that the majority of participants (74%) in the experimental group successfully learned to self-regulate the NAcc. They also showed improved behavioral performance in motivation and decreased functional connectivity between the NAcc and the ventral medial prefrontal cortex and an increase in small-world properties in the reward circuit after training, indicating improved information integration in reward processing. However, improvement in motivation and modification of function connectivity were not observed in the sham control group and the participants who failed to self-regulate the NAcc in the experimental group. Self-regulation was influenced by the baseline motivation. Conclusions: These findings suggest that the NAcc could be self-regulated using real-time fMRI neurofeedback and can result in improved motivation in cognitive tasks.

KeywordReal-time Fmri Nucleus Accumbens Motivation Generalization Effect Reward
Funding ProjectNational Natural Science Fund China[91132701] ; National Natural Science Fund China[81571317] ; Beijing Training Project for the Leading Talents in Science Technology[Z151100000315020] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Chinese Academy of Sciences[XDB02030002] ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; CAS/SAFEA International Partnership Programme for Creative Research Teams[Y2CX131003] ; NIHR Biomedical Research Centre and Biomedical Research Unit in Dementia, at Cambridge University Hospitals NHS Foundation Trust ; University of Cambridge ; Alzheimer's Research UK
WOS KeywordStriatal Reward Prediction ; Incentive Salience ; Major Depression ; Anterior Insula ; Cue-reactivity ; Brain Activity ; Neurofeedback ; Schizophrenia ; Anhedonia ; Dysfunction
WOS Research AreaPsychology ; Neurosciences & Neurology
WOS SubjectPsychology, Clinical ; Neurosciences ; Psychology
WOS IDWOS:000443739600012
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorSu, Li; Chan, Raymond C. K.
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.East China Normal Univ, Sch Psychol & Cognit Sci, Key Lab Brain Funct Genom MOE & STCSM, Shanghai, Peoples R China
4.Hosp 306, MRI Ctr, Beijing, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
6.Univ Cambridge, Dept Psychiat, Cambridge, England
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Li, Zhi,Zhang, Chen-yuan,Huang, Jia,et al. Improving Motivation Through Real-Time fMRI-Based Self-Regulation of the Nucleus Accumbens[J]. NEUROPSYCHOLOGY,2018,32(6):764-776.
APA Li, Zhi.,Zhang, Chen-yuan.,Huang, Jia.,Wang, Yi.,Yan, Chao.,...&Chan, Raymond C. K..(2018).Improving Motivation Through Real-Time fMRI-Based Self-Regulation of the Nucleus Accumbens.NEUROPSYCHOLOGY,32(6),764-776.
MLA Li, Zhi,et al."Improving Motivation Through Real-Time fMRI-Based Self-Regulation of the Nucleus Accumbens".NEUROPSYCHOLOGY 32.6(2018):764-776.
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