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Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span | |
Tsvetanov, Kamen A.1,2,3,6; Ye, Zheng4,5; Hughes, Laura6; Samu, David1,2,3; Treder, Matthias S.2,3,8; Wolpe, Noham2,3,6,7; Tyler, Lorraine K.1,2,3; Rowe, James B.2,3,6,7 | |
第一作者 | kat35@cam.ac.uk |
通讯作者邮箱 | kamen a. tsvetanov |
摘要 | Inhibitory control requires precise regulation of activity and connectivity within multiple brain networks. Previous studies have typically evaluated age-related changes in regional activity or changes in interregional interactions. Instead, we test the hypothesis that activity and connectivity make distinct, complementary contributions to performance across the life span and the maintenance of successful inhibitory control systems. A representative sample of healthy human adults in a large, population-based life span cohort performed an integrated Stop-Signal (SS)/No-Go task during functional magnetic resonance imaging (n = 119; age range, 18 - 88 years). Individual differences in inhibitory control were measured in terms of the SS reaction time (SSRT), using the blocked integration method. Linear models and independent components analysis revealed that individual differences in SSRT correlated with both activity and connectivity in a distributed inhibition network, comprising prefrontal, premotor, and motor regions. Importantly, this pattern was moderated by age, such that the association between inhibitory control and connectivity, but not activity, differed with age. Multivariate statistics and out-of-sample validation tests of multifactorial functional organization identified differential roles of activity and connectivity in determining an individual's SSRT across the life span. We propose that age-related differences in adaptive cognitive control are best characterized by the joint consideration of multifocal activity and connectivity within distributed brain networks. These insights may facilitate the development of new strategies to support cognitive ability in old age. |
关键词 | Aging Functional Magnetic Resonance Imaging (Fmri) Individual Differences Inhibitory Control Network Connectivity Regional Activity |
2018-09-05 | |
语种 | 英语 |
DOI | 10.1523/JNEUROSCI.2919-17.2018 |
发表期刊 | JOURNAL OF NEUROSCIENCE |
ISSN | 0270-6474 |
卷号 | 38期号:36页码:7887-7900 |
资助项目 | Biotechnology and Biological Sciences Research Council[BB/H008217/1] ; British Academy Post-doctoral Fellowship[PF160048] ; Wellcome Trust[103838] ; James S. McDonnell Foundation |
出版者 | SOC NEUROSCIENCE |
WOS关键词 | Inferior Frontal-cortex ; Stop-signal Task ; Resting State Fmri ; Response-inhibition ; Functional Connectivity ; Prefrontal Cortex ; Individual-differences ; Executive Functions ; Motion Artifact ; Attentional Control |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000443711100014 |
资助机构 | Biotechnology and Biological Sciences Research Council ; British Academy Post-doctoral Fellowship ; Wellcome Trust ; James S. McDonnell Foundation |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/26959 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Tsvetanov, Kamen A. |
作者单位 | 1.Univ Cambridge, Ctr Speech Language & Brain, Cambridge CB2 3EB, England 2.Univ Cambridge, Cambridge Ctr Ageing & Neurosci Cam CAN, Dept Psychol, Cambridge CB2 3EB, England 3.Univ Cambridge, MRC, Cognit & Brain Sci Unit, Cambridge CB2 3EB, England 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 201204, Peoples R China 6.Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 2PY, England 7.MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England 8.Cardiff Univ, Sch Comp Sci & Informat, Cardiff CF24 3AA, S Glam, Wales |
推荐引用方式 GB/T 7714 | Tsvetanov, Kamen A.,Ye, Zheng,Hughes, Laura,et al. Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span[J]. JOURNAL OF NEUROSCIENCE,2018,38(36):7887-7900. |
APA | Tsvetanov, Kamen A..,Ye, Zheng.,Hughes, Laura.,Samu, David.,Treder, Matthias S..,...&Rowe, James B..(2018).Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span.JOURNAL OF NEUROSCIENCE,38(36),7887-7900. |
MLA | Tsvetanov, Kamen A.,et al."Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span".JOURNAL OF NEUROSCIENCE 38.36(2018):7887-7900. |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Activity and Connect(5857KB) | 期刊论文 | 作者原稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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