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Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span
Tsvetanov, Kamen A.1,2,3,6; Ye, Zheng4,5; Hughes, Laura6; Samu, David1,2,3; Treder, Matthias S.2,3,8; Wolpe, Noham2,3,6,7; Tyler, Lorraine K.1,2,3; Rowe, James B.2,3,6,7
第一作者kat35@cam.ac.uk
2018-09-05
发表期刊JOURNAL OF NEUROSCIENCE
通讯作者邮箱kamen a. tsvetanov
ISSN0270-6474
卷号38期号:36页码:7887-7900
摘要

Inhibitory control requires precise regulation of activity and connectivity within multiple brain networks. Previous studies have typically evaluated age-related changes in regional activity or changes in interregional interactions. Instead, we test the hypothesis that activity and connectivity make distinct, complementary contributions to performance across the life span and the maintenance of successful inhibitory control systems. A representative sample of healthy human adults in a large, population-based life span cohort performed an integrated Stop-Signal (SS)/No-Go task during functional magnetic resonance imaging (n = 119; age range, 18 - 88 years). Individual differences in inhibitory control were measured in terms of the SS reaction time (SSRT), using the blocked integration method. Linear models and independent components analysis revealed that individual differences in SSRT correlated with both activity and connectivity in a distributed inhibition network, comprising prefrontal, premotor, and motor regions. Importantly, this pattern was moderated by age, such that the association between inhibitory control and connectivity, but not activity, differed with age. Multivariate statistics and out-of-sample validation tests of multifactorial functional organization identified differential roles of activity and connectivity in determining an individual's SSRT across the life span. We propose that age-related differences in adaptive cognitive control are best characterized by the joint consideration of multifocal activity and connectivity within distributed brain networks. These insights may facilitate the development of new strategies to support cognitive ability in old age.

关键词Aging Functional Magnetic Resonance Imaging (Fmri) Individual Differences Inhibitory Control Network Connectivity Regional Activity
DOI10.1523/JNEUROSCI.2919-17.2018
语种英语
项目资助者Biotechnology and Biological Sciences Research Council ; British Academy Post-doctoral Fellowship ; Thousand Young Talents Program ; Wellcome Trust ; James S. McDonnell Foundation
资助项目Biotechnology and Biological Sciences Research Council[BB/H008217/1] ; British Academy Post-doctoral Fellowship[PF160048] ; Thousand Young Talents Program ; Wellcome Trust[103838] ; James S. McDonnell Foundation
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000443711100014
出版者SOC NEUROSCIENCE
关键词[WOS]Inferior Frontal-cortex ; Stop-signal Task ; Resting State Fmri ; Response-inhibition ; Functional Connectivity ; Prefrontal Cortex ; Individual-differences ; Executive Functions ; Motion Artifact ; Attentional Control
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26959
专题中国科学院心理健康重点实验室
通讯作者Tsvetanov, Kamen A.
作者单位1.Univ Cambridge, Ctr Speech Language & Brain, Cambridge CB2 3EB, England
2.Univ Cambridge, Cambridge Ctr Ageing & Neurosci Cam CAN, Dept Psychol, Cambridge CB2 3EB, England
3.Univ Cambridge, MRC, Cognit & Brain Sci Unit, Cambridge CB2 3EB, England
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 201204, Peoples R China
6.Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 2PY, England
7.MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England
8.Cardiff Univ, Sch Comp Sci & Informat, Cardiff CF24 3AA, S Glam, Wales
推荐引用方式
GB/T 7714
Tsvetanov, Kamen A.,Ye, Zheng,Hughes, Laura,et al. Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span[J]. JOURNAL OF NEUROSCIENCE,2018,38(36):7887-7900.
APA Tsvetanov, Kamen A..,Ye, Zheng.,Hughes, Laura.,Samu, David.,Treder, Matthias S..,...&Rowe, James B..(2018).Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span.JOURNAL OF NEUROSCIENCE,38(36),7887-7900.
MLA Tsvetanov, Kamen A.,et al."Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span".JOURNAL OF NEUROSCIENCE 38.36(2018):7887-7900.
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