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Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span
Tsvetanov, Kamen A.1,2,3,6; Ye, Zheng4,5; Hughes, Laura6; Samu, David1,2,3; Treder, Matthias S.2,3,8; Wolpe, Noham2,3,6,7; Tyler, Lorraine K.1,2,3; Rowe, James B.2,3,6,7
Correspondent Emailkamen a. tsvetanov

Inhibitory control requires precise regulation of activity and connectivity within multiple brain networks. Previous studies have typically evaluated age-related changes in regional activity or changes in interregional interactions. Instead, we test the hypothesis that activity and connectivity make distinct, complementary contributions to performance across the life span and the maintenance of successful inhibitory control systems. A representative sample of healthy human adults in a large, population-based life span cohort performed an integrated Stop-Signal (SS)/No-Go task during functional magnetic resonance imaging (n = 119; age range, 18 - 88 years). Individual differences in inhibitory control were measured in terms of the SS reaction time (SSRT), using the blocked integration method. Linear models and independent components analysis revealed that individual differences in SSRT correlated with both activity and connectivity in a distributed inhibition network, comprising prefrontal, premotor, and motor regions. Importantly, this pattern was moderated by age, such that the association between inhibitory control and connectivity, but not activity, differed with age. Multivariate statistics and out-of-sample validation tests of multifactorial functional organization identified differential roles of activity and connectivity in determining an individual's SSRT across the life span. We propose that age-related differences in adaptive cognitive control are best characterized by the joint consideration of multifocal activity and connectivity within distributed brain networks. These insights may facilitate the development of new strategies to support cognitive ability in old age.

KeywordAging Functional Magnetic Resonance Imaging (Fmri) Individual Differences Inhibitory Control Network Connectivity Regional Activity
Funding ProjectBiotechnology and Biological Sciences Research Council[BB/H008217/1] ; British Academy Post-doctoral Fellowship[PF160048] ; Wellcome Trust[103838] ; James S. McDonnell Foundation
WOS KeywordInferior Frontal-cortex ; Stop-signal Task ; Resting State Fmri ; Response-inhibition ; Functional Connectivity ; Prefrontal Cortex ; Individual-differences ; Executive Functions ; Motion Artifact ; Attentional Control
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000443711100014
Funding OrganizationBiotechnology and Biological Sciences Research Council ; British Academy Post-doctoral Fellowship ; Wellcome Trust ; James S. McDonnell Foundation
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorTsvetanov, Kamen A.
Affiliation1.Univ Cambridge, Ctr Speech Language & Brain, Cambridge CB2 3EB, England
2.Univ Cambridge, Cambridge Ctr Ageing & Neurosci Cam CAN, Dept Psychol, Cambridge CB2 3EB, England
3.Univ Cambridge, MRC, Cognit & Brain Sci Unit, Cambridge CB2 3EB, England
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
5.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai 201204, Peoples R China
6.Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 2PY, England
7.MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England
8.Cardiff Univ, Sch Comp Sci & Informat, Cardiff CF24 3AA, S Glam, Wales
Recommended Citation
GB/T 7714
Tsvetanov, Kamen A.,Ye, Zheng,Hughes, Laura,et al. Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span[J]. JOURNAL OF NEUROSCIENCE,2018,38(36):7887-7900.
APA Tsvetanov, Kamen A..,Ye, Zheng.,Hughes, Laura.,Samu, David.,Treder, Matthias S..,...&Rowe, James B..(2018).Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span.JOURNAL OF NEUROSCIENCE,38(36),7887-7900.
MLA Tsvetanov, Kamen A.,et al."Activity and Connectivity Differences Underlying Inhibitory Control Across the Adult Life Span".JOURNAL OF NEUROSCIENCE 38.36(2018):7887-7900.
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