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Altered brain activation and connectivity during anticipation of uncertain threat in trait anxiety
Geng, Haiyang1,2,3,4,5; Wang, Yi1,2; Gu, Ruolei2,6; Luo, Yue-Jia3,4; Xu, Pengfei3; Huang, Yuxia7,8; Li, Xuebing1,2
2018-10-01
发表期刊HUMAN BRAIN MAPPING
ISSN1065-9471
卷号39期号:10页码:3898-3914
摘要In the research field of anxiety, previous studies generally focus on emotional responses following threat. A recent model of anxiety proposes that altered anticipation prior to uncertain threat is related with the development of anxiety. Behavioral findings have built the relationship between anxiety and distinct anticipatory processes including attention, estimation of threat, and emotional responses. However, few studies have characterized the brain organization underlying anticipation of uncertain threat and its role in anxiety. In the present study, we used an emotional anticipation paradigm with functional magnetic resonance imaging (fMRI) to examine the aforementioned topics by employing brain activation and general psychophysiological interactions (gPPI) analysis. In the activation analysis, we found that high trait anxious individuals showed significantly increased activation in the thalamus, middle temporal gyrus (MTG), and dorsomedial prefrontal cortex (dmPFC), as well as decreased activation in the precuneus, during anticipation of uncertain threat compared to the certain condition. In the gPPI analysis, the key regions including the amygdala, dmPFC, and precuneus showed altered connections with distributed brain areas including the ventromedial prefrontal cortex (vmPFC), dorsolateral prefrontal cortex (dlPFC), inferior parietal sulcus (IPS), insula, para-hippocampus gyrus (PHA), thalamus, and MTG involved in anticipation of uncertain threat in anxious individuals. Taken together, our findings indicate that during the anticipation of uncertain threat, anxious individuals showed altered activations and functional connectivity in widely distributed brain areas, which may be critical for abnormal perception, estimation, and emotion reactions during the anticipation of uncertain threat.
关键词trait anxiety uncertainty and anticipation model of anxiety (UAMA) functional connectivity amygdala dmPFC precuneus
DOI10.1002/hbm.24219
语种英语
项目资助者National Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning, Shenzhen Peacock Plan ; Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant
资助项目National Natural Science Foundation of China[31671136] ; National Natural Science Foundation of China[31530031] ; National Natural Science Foundation of China[31571124] ; National Natural Science Foundation of China[81471376] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning, Shenzhen Peacock Plan[KQTD2015033016104926] ; Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant[2016ZT06S220]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000443941200007
出版者WILEY
关键词[WOS]FUNCTIONAL-ANATOMY ; INSULA ACTIVATION ; DECISION-MAKING ; FEARFUL FACES ; NETWORKS ; DISORDER ; AMYGDALA ; AVERSION ; EMOTION ; EVENTS
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/26961
专题中国科学院心理健康重点实验室
通讯作者Li, Xuebing
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 10049, Peoples R China
3.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Peoples R China
4.Shenzhen Inst Neurosci, Ctr Emot & Brain, Shenzhen 518057, Peoples R China
5.Univ Groningen, Univ Med Ctr Groningen, BCN Neuroimaging Ctr, Groningen, Netherlands
6.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
7.Beijing Normal Univ, State Key Lab Cognit Neuroscience & Learning, Beijing 100875, Peoples R China
8.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
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Geng, Haiyang,Wang, Yi,Gu, Ruolei,et al. Altered brain activation and connectivity during anticipation of uncertain threat in trait anxiety[J]. HUMAN BRAIN MAPPING,2018,39(10):3898-3914.
APA Geng, Haiyang.,Wang, Yi.,Gu, Ruolei.,Luo, Yue-Jia.,Xu, Pengfei.,...&Li, Xuebing.(2018).Altered brain activation and connectivity during anticipation of uncertain threat in trait anxiety.HUMAN BRAIN MAPPING,39(10),3898-3914.
MLA Geng, Haiyang,et al."Altered brain activation and connectivity during anticipation of uncertain threat in trait anxiety".HUMAN BRAIN MAPPING 39.10(2018):3898-3914.
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