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Altered brain activation and connectivity during anticipation of uncertain threat in trait anxiety
Geng, Haiyang1,2,3,4,5; Wang, Yi1,2; Gu, Ruolei2,6; Luo, Yue-Jia3,4; Xu, Pengfei3; Huang, Yuxia7,8; Li, Xuebing1,2
First AuthorGeng, Haiyang
2018-10-01
Source PublicationHUMAN BRAIN MAPPING
Correspondent Emaillixb@psych.ac.cn
ISSN1065-9471
SubtypeArticle
Volume39Issue:10Pages:3898-3914
Contribution Rank1
Abstract

In the research field of anxiety, previous studies generally focus on emotional responses following threat. A recent model of anxiety proposes that altered anticipation prior to uncertain threat is related with the development of anxiety. Behavioral findings have built the relationship between anxiety and distinct anticipatory processes including attention, estimation of threat, and emotional responses. However, few studies have characterized the brain organization underlying anticipation of uncertain threat and its role in anxiety. In the present study, we used an emotional anticipation paradigm with functional magnetic resonance imaging (fMRI) to examine the aforementioned topics by employing brain activation and general psychophysiological interactions (gPPI) analysis. In the activation analysis, we found that high trait anxious individuals showed significantly increased activation in the thalamus, middle temporal gyrus (MTG), and dorsomedial prefrontal cortex (dmPFC), as well as decreased activation in the precuneus, during anticipation of uncertain threat compared to the certain condition. In the gPPI analysis, the key regions including the amygdala, dmPFC, and precuneus showed altered connections with distributed brain areas including the ventromedial prefrontal cortex (vmPFC), dorsolateral prefrontal cortex (dlPFC), inferior parietal sulcus (IPS), insula, para-hippocampus gyrus (PHA), thalamus, and MTG involved in anticipation of uncertain threat in anxious individuals. Taken together, our findings indicate that during the anticipation of uncertain threat, anxious individuals showed altered activations and functional connectivity in widely distributed brain areas, which may be critical for abnormal perception, estimation, and emotion reactions during the anticipation of uncertain threat.

KeywordTrait Anxiety Uncertainty And Anticipation Model Of Anxiety (Uama) Functional Connectivity Amygdala Dmpfc Precuneus
DOI10.1002/hbm.24219
Indexed BySCIE
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning, Shenzhen Peacock Plan ; Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant
Funding ProjectNational Natural Science Foundation of China[31671136] ; National Natural Science Foundation of China[31530031] ; National Natural Science Foundation of China[31571124] ; National Natural Science Foundation of China[81471376] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning, Shenzhen Peacock Plan[KQTD2015033016104926] ; Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team grant[2016ZT06S220]
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000443941200007
PublisherWILEY
WOS KeywordFunctional-anatomy ; Insula Activation ; Decision-making ; Fearful Faces ; Networks ; Disorder ; Amygdala ; Aversion ; Emotion ; Events
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/26961
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Xuebing
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 10049, Peoples R China
3.Shenzhen Univ, Shenzhen Key Lab Affect & Social Cognit Sci, Shenzhen 518060, Peoples R China
4.Shenzhen Inst Neurosci, Ctr Emot & Brain, Shenzhen 518057, Peoples R China
5.Univ Groningen, Univ Med Ctr Groningen, BCN Neuroimaging Ctr, Groningen, Netherlands
6.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China
7.Beijing Normal Univ, State Key Lab Cognit Neuroscience & Learning, Beijing 100875, Peoples R China
8.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Geng, Haiyang,Wang, Yi,Gu, Ruolei,et al. Altered brain activation and connectivity during anticipation of uncertain threat in trait anxiety[J]. HUMAN BRAIN MAPPING,2018,39(10):3898-3914.
APA Geng, Haiyang.,Wang, Yi.,Gu, Ruolei.,Luo, Yue-Jia.,Xu, Pengfei.,...&Li, Xuebing.(2018).Altered brain activation and connectivity during anticipation of uncertain threat in trait anxiety.HUMAN BRAIN MAPPING,39(10),3898-3914.
MLA Geng, Haiyang,et al."Altered brain activation and connectivity during anticipation of uncertain threat in trait anxiety".HUMAN BRAIN MAPPING 39.10(2018):3898-3914.
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