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Cortical thickness correlates of minor neurological signs in patients with first episode psychosis
Ciufolini, Simone1; Ponteduro, Maria Francesca1; Reis-Marques, Tiago1; Taylor, Heather1; Mondelli, Valeria3; Pariante, Carmine M.3; Bonaccorso, Stefania1; Chan, Raymond4; Simmons, Andy2; David, Anthony1; Di Forti, Marta7; Murray, Robin M.1; Dazzan, Paola1,5,6
First AuthorCiufolini, Simone
2018-10-01
Source PublicationSCHIZOPHRENIA RESEARCH
Correspondent Emailsimone.ciufolini@kcl.ac.uk (s. ciufolini)
ISSN0920-9964
SubtypeArticle
Volume200Pages:104-111
Contribution Rank4
Abstract

Neurological soft signs (NSS) are subtle abnormalities of motor and sensory function that are present in the absence of localized brain pathological lesions. In psychoses they have been consistently associated with a distinct pattern of cortical and subcortical brain structural alterations at the level of the heteromodal cortex and basal ganglia. However, a more specific and accurate evaluation of the cytoarchitecture of the cortical mantle could further advance our understanding of the neurobiological substrate of psychosis. We investigated the relationship between brain structure and NSS in a sample of 66 patients at their first episode of psychosis. We used the Neurological Evaluation Scale for neurological assessment and high-resolution MRI and Freesurfer to explore cortical thickness and surface area. Higher rates of NSS were associated with a reduction of cortical thickness in the precentral and postcentral gyri, inferior-parietal, superior temporal, and fusiform gyri. Higher rates of NSS were also associated with smaller surface areas of superior temporal gyrus and frontal regions (including middle frontal, superior and orbito-frontal gyri). Finally, more sensory integration signs were also associated with larger surface area of the latero-occipital region. We conclude that the presence of NSS in psychosis is associated with distinct but widespread changes in cortical thickness and surface area, in areas crucial for sensory-motor integration and for the fluid execution of movement. Studying these morphological correlates with advanced neuroimaging techniques can continue to improve our knowledge on the neurobiological substrate of these important functional correlates of psychosis. Crown Copyright (C) 2018 Published by Elsevier B.V. All rights reserved.

KeywordNeurological Soft Signs First-episode Psychosis Magnetic Resonance Imaging Cortical Thickness
DOI10.1016/j.schres.2018.05.005
Indexed BySCIE
Language英语
Funding OrganizationNational Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
Funding ProjectNational Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000445244900015
PublisherELSEVIER SCIENCE BV
WOS KeywordHuman Cerebral-cortex ; Soft Signs ; 1st-episode Schizophrenia ; Brain Structure ; Life-span ; Abnormalities ; Metaanalysis ; Morphology ; Spectrum ; System
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27006
Collection健康与遗传心理学研究室
Corresponding AuthorCiufolini, Simone
Affiliation1.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
2.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Neuroimaging, London, England
3.Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England
4.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, Inst Psychol, Beijing, Peoples R China
5.South London & Maudsley NHS Fdn Trust, Mental Hlth Biomed Res Ctr, NIHR, London, England
6.Kings Coll London, London, England
7.Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat, London, England
Recommended Citation
GB/T 7714
Ciufolini, Simone,Ponteduro, Maria Francesca,Reis-Marques, Tiago,et al. Cortical thickness correlates of minor neurological signs in patients with first episode psychosis[J]. SCHIZOPHRENIA RESEARCH,2018,200:104-111.
APA Ciufolini, Simone.,Ponteduro, Maria Francesca.,Reis-Marques, Tiago.,Taylor, Heather.,Mondelli, Valeria.,...&Dazzan, Paola.(2018).Cortical thickness correlates of minor neurological signs in patients with first episode psychosis.SCHIZOPHRENIA RESEARCH,200,104-111.
MLA Ciufolini, Simone,et al."Cortical thickness correlates of minor neurological signs in patients with first episode psychosis".SCHIZOPHRENIA RESEARCH 200(2018):104-111.
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