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Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples
Zhou, Han-yu1,2; Wong, Keri Ka-Yee3; Shi, Li-juan1,4; Cui, Xi-long5; Qian, Yun6; Jiang, Wen-qing6; Du, Ya-song6; Lui, Simon S. Y.1,5,7; Luo, Xue-rong; Yi, Zheng-hui6; Cheung, Eric F. C.7; Docherty, Anna R.8,9; Chan, Raymond C. K.1,2
AbstractBackground: We validated the Social Mistrust Scale (SMS) and utilized it to examine the structure, prevalence, and heritability of social mistrust in a large sample of Chinese children and adolescents. Methods: In Study 1, a large sample of healthy twins (N=2094) aged 8 to 14 years (M=10.27 years, SD=2) completed the SMS. Structural equation modeling (SEM) was conducted to assess the structure of the SMS and to estimate the heritability of social mistrust in a sub-sample of twins (n=756 pairs). In Study 2, 32 adolescents with childhood-onset schizophrenia were compared with 34 healthy controls on levels of suspiciousness and clinical symptoms to examine the associations between the SMS and the Positive and Negative Syndrome Scale (PANSS). Results: We found a three-factor structure for social mistrust (home, school, and general mistrust). Social mistrust was found to be moderately - heritable (19%-40%), with mistrust at home most strongly influenced by genetic factors. Compared with 11.76% of the healthy controls, 56.25% of the adolescents with early-onset schizophrenia exhibited very high levels of social mistrust on all three subscales of the SMS. The SMS exhibited good discriminant validity in distinguishing adolescents with childhood-onset schizophrenia from healthy controls and showed associations with a broad range of symptoms assessed by the PANSS. Conclusions: Social mistrust assessed by the SMS may be heritable. The SMS demonstrates good discriminant validity with clinical diagnoses of schizophrenia. However, it seems to be correlated with multiple aspects of psychopathology in the schizophrenia group, rather than being specific to delusional ideation/paranoia. (c) 2018 Elsevier B.V. All rights reserved.
KeywordSocial mistrust Suspiciousness Heritability Child Schizophrenia
Funding ProjectNational Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; Beijing Municipal Science & Technology Commission Grant[Z161100000216138] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; Betty Behrens Research Fellowship at Clare Hall College, University of Cambridge
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000444845900021
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorChan, Raymond C. K.
Affiliation1.CAS Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Univ Cambridge, Dept Psychol, Cambridge, Cambs, England
4.Hunan Univ Sci & Technol, Sch Educ, Xiangtan, Hunan, Peoples R China
5.Cent S Univ, Natl Technol Inst Psychiat, Xiangya Hosp 2, Mental Hlth Inst,Key Lab Psychiat & Mental Hlth H, Changsha, Hunan, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China
7.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
8.Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84112 USA
9.Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
Recommended Citation
GB/T 7714
Zhou, Han-yu,Wong, Keri Ka-Yee,Shi, Li-juan,et al. Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples[J]. SCHIZOPHRENIA RESEARCH,2018,199:135-141.
APA Zhou, Han-yu.,Wong, Keri Ka-Yee.,Shi, Li-juan.,Cui, Xi-long.,Qian, Yun.,...&Chan, Raymond C. K..(2018).Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples.SCHIZOPHRENIA RESEARCH,199,135-141.
MLA Zhou, Han-yu,et al."Suspiciousness in young minds: Convergent evidence from non-clinical, clinical and community twin samples".SCHIZOPHRENIA RESEARCH 199(2018):135-141.
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