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Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex
Broster, Lucas S.1,2; Li, Juan1,3; Wagner, Benjamin1; Smith, Charles D.4,5,6; Jicha, Gregory A.4,5; Schmitt, Frederick A.2,4,5; Munro, Nancy7; Haney, Ryan H.1; Jiang, Yang1,5,6
第一作者Broster, Lucas S.
2018
发表期刊JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
通讯作者邮箱lukebroster@gmail.com
ISSN1380-3395
文章类型Article
卷号40期号:8页码:761-776
产权排序3
摘要

Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD.

关键词Alzheimer's Disease Event-related Potentials Mild Cognitive Impairment Repetition Effects Working Memory
DOI10.1080/13803395.2018.1430230
收录类别SCIE
语种英语
项目资助者University of Kentucky Department of Behavioral Science ; U.S. Department of Energy ; National Institute of Health: National Institute on Aging ; National Institute of Mental Health ; National Center for Advancing Translational Sciences
资助项目University of Kentucky Department of Behavioral Science ; U.S. Department of Energy[DE-AC03-OR22725] ; National Institute of Health: National Institute on Aging[P50 AG05144-21] ; National Institute of Health: National Institute on Aging[AG000986] ; National Institute of Health: National Institute on Aging[5P30AG028383] ; National Institute of Health: National Institute on Aging[810 5 T32 AG 242-18] ; National Institute of Mental Health[R25 MH060482] ; National Center for Advancing Translational Sciences[UL1RR033173] ; National Center for Advancing Translational Sciences[UL1TR000117]
WOS研究方向Psychology ; Neurosciences & Neurology
WOS类目Psychology, Clinical ; Clinical Neurology ; Psychology
WOS记录号WOS:000445103200002
出版者TAYLOR & FRANCIS INC
关键词[WOS]Mild Cognitive Impairment ; Event-related Potentials ; Default-mode Network ; Working-memory ; Brain Activity ; Association Workgroups ; Diagnostic Guidelines ; National Institute ; Older Controls ; Dementia
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27008
专题中国科学院心理健康重点实验室
通讯作者Broster, Lucas S.
作者单位1.Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA
2.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
4.Univ Kentucky, Dept Neurol, Coll Med, Lexington, KY 40536 USA
5.Univ Kentucky, Sanders Brown Ctr Aging, Coll Med, Lexington, KY 40536 USA
6.Univ Kentucky, Magnet Resonance Imaging & Spect Ctr, Coll Med, Lexington, KY 40536 USA
7.Oak Ridge Natl Lab, Oak Ridge, TN USA
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GB/T 7714
Broster, Lucas S.,Li, Juan,Wagner, Benjamin,et al. Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex[J]. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,2018,40(8):761-776.
APA Broster, Lucas S..,Li, Juan.,Wagner, Benjamin.,Smith, Charles D..,Jicha, Gregory A..,...&Jiang, Yang.(2018).Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,40(8),761-776.
MLA Broster, Lucas S.,et al."Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex".JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY 40.8(2018):761-776.
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