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Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex | |
Broster, Lucas S.1,2; Li, Juan1,3; Wagner, Benjamin1; Smith, Charles D.4,5,6; Jicha, Gregory A.4,5; Schmitt, Frederick A.2,4,5; Munro, Nancy7; Haney, Ryan H.1; Jiang, Yang1,5,6 | |
第一作者 | Broster, Lucas S. |
通讯作者邮箱 | lukebroster@gmail.com |
心理所单位排序 | 3 |
摘要 | Objective: Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex. Method: Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects. Results: Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect. Conclusion: Visual cortex may play a role in maintained repetition effects in persons with early AD. |
关键词 | Alzheimer's Disease Event-related Potentials Mild Cognitive Impairment Repetition Effects Working Memory |
2018 | |
语种 | 英语 |
DOI | 10.1080/13803395.2018.1430230 |
发表期刊 | JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY |
ISSN | 1380-3395 |
卷号 | 40期号:8页码:761-776 |
期刊论文类型 | Article |
收录类别 | SCIE |
资助项目 | University of Kentucky Department of Behavioral Science ; U.S. Department of Energy[DE-AC03-OR22725] ; National Institute of Health: National Institute on Aging[P50 AG05144-21] ; National Institute of Health: National Institute on Aging[AG000986] ; National Institute of Health: National Institute on Aging[5P30AG028383] ; National Institute of Health: National Institute on Aging[810 5 T32 AG 242-18] ; National Institute of Mental Health[R25 MH060482] ; National Center for Advancing Translational Sciences[UL1RR033173] ; National Center for Advancing Translational Sciences[UL1TR000117] |
出版者 | TAYLOR & FRANCIS INC |
WOS关键词 | Mild Cognitive Impairment ; Event-related Potentials ; Default-mode Network ; Working-memory ; Brain Activity ; Association Workgroups ; Diagnostic Guidelines ; National Institute ; Older Controls ; Dementia |
WOS研究方向 | Psychology ; Neurosciences & Neurology |
WOS类目 | Psychology, Clinical ; Clinical Neurology ; Psychology |
WOS记录号 | WOS:000445103200002 |
资助机构 | University of Kentucky Department of Behavioral Science ; U.S. Department of Energy ; National Institute of Health: National Institute on Aging ; National Institute of Mental Health ; National Center for Advancing Translational Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/27008 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Broster, Lucas S. |
作者单位 | 1.Univ Kentucky, Coll Med, Dept Behav Sci, 113 Med Behav Sci Bldg, Lexington, KY 40536 USA 2.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 4.Univ Kentucky, Dept Neurol, Coll Med, Lexington, KY 40536 USA 5.Univ Kentucky, Sanders Brown Ctr Aging, Coll Med, Lexington, KY 40536 USA 6.Univ Kentucky, Magnet Resonance Imaging & Spect Ctr, Coll Med, Lexington, KY 40536 USA 7.Oak Ridge Natl Lab, Oak Ridge, TN USA |
推荐引用方式 GB/T 7714 | Broster, Lucas S.,Li, Juan,Wagner, Benjamin,et al. Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex[J]. JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,2018,40(8):761-776. |
APA | Broster, Lucas S..,Li, Juan.,Wagner, Benjamin.,Smith, Charles D..,Jicha, Gregory A..,...&Jiang, Yang.(2018).Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY,40(8),761-776. |
MLA | Broster, Lucas S.,et al."Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex".JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY 40.8(2018):761-776. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Spared behavioral re(2073KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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