PSYCH OpenIR  > 健康与遗传心理学研究室
Alternative TitlePlasticity of the prefrontal cortex in old age and underlying mechanisms
王晨茜; 陈天勇; 韩布新
First Author王晨茜
Source Publication心理科学进展


Other Abstract

Previous studies have shown that structure and function of the prefrontal cortex (PFC) are particularly vulnerable to aging. On the other hand, recent studies have also indicated that the structural and functional plasticity of PFC is preserved in old age. For older adults, cognitive training attenuates reduction of cortical thickness in PFC, increases white matter integrity, improves intra- and inter-network functional connectivity, and also changes functional activation through modulation of dopamine activity in PFC and subcortical structures. Aerobic exercise improves cardiovascular fitness, preserves neuronal integrity and promotes neurogenesis, which would then lead to increased volumes in prefrontal gray and white matter, and altered functional activation patterns. Multimodal intervention, which combines cognitive training and physical exercise, has demonstrated better ecological validity, enhancing everyday cognition and life quality of older adults. We suggest that future studies should adopt various techniques, in order to better understand the prefrontal neuroplasticity in old age and its related mechanisms; separately analyze the various PFC related cognitive abilities; and lay stress on the more ecological multimodal intervention.

Keyword前额叶 执行功能 老年 神经可塑性
Indexed ByCSCD
Citation statistics
Cited Times:1[CSCD]   [CSCD Record]
Document Type期刊论文
Recommended Citation
GB/T 7714
王晨茜,陈天勇,韩布新. 前额叶在老年阶段的可塑性及相关机制[J]. 心理科学进展,2018,26(11):2003–2012.
APA 王晨茜,陈天勇,&韩布新.(2018).前额叶在老年阶段的可塑性及相关机制.心理科学进展,26(11),2003–2012.
MLA 王晨茜,et al."前额叶在老年阶段的可塑性及相关机制".心理科学进展 26.11(2018):2003–2012.
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