PSYCH OpenIR  > 中国科学院心理健康重点实验室
抑郁症认知功能损伤及异常脑机制研究进展
其他题名Cognitive dysfunction and brain mechanisms in major depression disorder
刘佳丽1,2; 王亮1,2,3
第一作者刘佳丽
2018
发表期刊科学通报
通讯作者邮箱lwang@psych.ac.cn
ISSN0023-074X
文章类型期刊论文
卷号63期号:20页码:1973 ~ 1983
产权排序1
摘要

认知损伤不仅是抑郁症患者的重要症状,也阻碍着抑郁症状的消除和疾病的整体康复,因此,探讨抑郁症认知缺陷及异常脑机制对了解抑郁症的病因、诊断和治疗意义重大.本文从执行功能、注意、记忆、反应速度等维度讨论抑郁症认知功能缺陷,并阐述其背后的异常宏观脑活动和微观分子标记.未来研究我们建议借助心理认知任务定量评估抑郁症认知功能,同时采集患者多模态脑影像和神经生理数据,通过多维数据计算建模分析,探寻抑郁症潜在生物标记,进而对抑郁症进行生物亚型分类,为深入理解抑郁症发病机理和个体化诊疗提供科学依据. 

其他摘要

The prevalence of major depressed disorder increased rapidly in recent year all over the world and has become a heavy burden of society. So research on depression has become a hot topic. A great amount of studies found that patients with major depression disorder had impaired cognition. Cognitive dysfunction, the important symptom of depression, has been regarded as not only an indicator of illness, but also an obstacle to the elimination of depressive mood and the overall recovery of the disease. Exploring cognitive dysfunction and the potential brain mechanism meant significantly to understanding the etiology of major depression disorder, which could benefit the prevention, diagnosis, treatment of this mental disease. Therefore, the current research aimed to discuss cognitive dysfunction, the potential brain mechanism of the impaired dysfunction as well as the molecular factors behind major depression disorder, try to threw light on the abnormal macro-brain activity and micro-molecular marker of major depression disorder. The literatures showed that patients with major depression disorder had abnormalities in executive function, attention, memory and reaction speed. Deficit in executive function was mainly related to abnormality in prefrontal lobe and the connected subcutaneous nuclei; attention deficits had connection with abnormality in the frontal network connection, occipital lobe and cingulate gyrus; and memory defects are corresponded to abnormality in the hippocampus, cingulate gyrus, and medial temporal cortex. In addition, the abnormal neurotransmitters or brain-derived neuronal factors, and long-term stress state may also be the cause of depressive symptoms and abnormal cognitive levels. At present, the study of brain structure is relatively rough, mainly focusing on the changes in a big brain area, such as the hippocampus, prefrontal cortex, etc. In the future, high-resolution magnetic resonance imaging technology are needed to study more refined brain structures, such as CA1-3, entorhinal cortex to provide biological targets for neuromodulation treatment of various non-pharmacological interventions. Future studies also need to balance as much as possible irrelevant variables such as disease progression, severity of depression, gender, and neuropsychological tests. Besides, the causal link between neuroimaging and molecular biomarkers and depression remains unclear and longitudinal studies should be taken into consideration. As for clinical studies, we suggested to improve the traditional criteria of mental illness classification by combining the biological abnormality found by research evidence. Specifically, future studies of major depression disorder can consider cognitive dysfunctions assessed by psychological cognitive tasks; multimodal brain image and neurophysiological data to construct multidimensional computational modeling, in order to systematically explore potential biomarkers of depression, further identify the subtypes of depression. New classification criteria would provide full understanding of the pathogenesis as well as individual diagnosis and treatment of major depression disorder.

关键词抑郁症 认知缺陷 脑机制 前额叶 海马
收录类别CSCD
语种中文
CSCD记录号CSCD:6332366
引用统计
被引频次:1[CSCD]   [CSCD记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27041
专题中国科学院心理健康重点实验室
脑与认知科学国家重点实验室
作者单位1.中国科学院心理健康重点实验室(中国科学院心理研究所)
2.中国科学院大学心理学系
3.中国科学院脑科学与智能技术卓越创新中心
第一作者单位中国科学院心理健康重点实验室
推荐引用方式
GB/T 7714
刘佳丽,王亮. 抑郁症认知功能损伤及异常脑机制研究进展[J]. 科学通报,2018,63(20):1973 ~ 1983.
APA 刘佳丽,&王亮.(2018).抑郁症认知功能损伤及异常脑机制研究进展.科学通报,63(20),1973 ~ 1983.
MLA 刘佳丽,et al."抑郁症认知功能损伤及异常脑机制研究进展".科学通报 63.20(2018):1973 ~ 1983.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
抑郁症认知功能损伤及异常脑机制研究进展_(1337KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[刘佳丽]的文章
[王亮]的文章
百度学术
百度学术中相似的文章
[刘佳丽]的文章
[王亮]的文章
必应学术
必应学术中相似的文章
[刘佳丽]的文章
[王亮]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 抑郁症认知功能损伤及异常脑机制研究进展_刘佳丽.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。