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Enhanced neural responses to monetary rewards in methamphetamine use disordered individuals compared to healthy controls
Wei, Shuguang1,2; Zheng, Ya3; Li, Qi2,4; Dai, Weine2,4; Sun, Jinxiu5; Wu, Haiyan2,4; Liu, Xun2,4
First AuthorWei, Shuguang
2018-10-15
Source PublicationPHYSIOLOGY & BEHAVIOR
Correspondent Emailliux@psych.ac.cn (x. liu)
ISSN0031-9384
SubtypeArticle
Volume195Pages:118-127
Contribution Rank2
Abstract

Converging evidence supports that addiction involves the pathological usurpation of normal reward processes. However, the nature and direction of reward processing dysfunction in substance abusers remain unclear. The current study explored the electrophysiological responses associated with different stages of reward processing in methamphetamine (MA) use disordered individuals. Electroencephalography recording was used to compare responses of 21 MA use disordered individuals and 22 healthy controls (HC) while participants engaged in a simple gambling task. Compared to HC, MA use disordered individuals made more risky choices following a loss outcome on a previous trial. During the reward anticipatory stage, MA use disordered individuals showed an enhanced stimulus-preceding negativity (SPN), as compared to HC. During the reward outcome stage, MA use disordered individuals showed an enhanced feedback-related negativity (FRN) for the losses versus gains as compared to HC. Furthermore, an enhanced P300 was observed under the gain condition, but not under the loss condition, in MA use disordered individuals as compared to HC. These findings provide further evidence that MA use disordered individuals have a sensitized neural response to non-drug rewards and support the impulsivity and incentive sensitization theories in MA use disordered individuals. The current study helps to elucidate the neural mechanisms of reward processing in MA use disordered individuals.

KeywordMethamphetamine Use Disorder Reward Processing Stimulus-preceding Negativity (Spn) Feedback-related Negativity (Frn) P300
DOI10.1016/j.physbeh.2018.08.003
Indexed BySCIE
Language英语
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China ; Postdoctoral Research Found from CAS Key Laboratory of Behavioral Science, Institute of Psychology ; Outstanding Foundation on Humanities and Social Sciences of Young People in Universities of Hebei Education Department
Funding ProjectNational Key R&D Program of China[2016YFC0800901-Z03] ; National Natural Science Foundation of China[31271194] ; Postdoctoral Research Found from CAS Key Laboratory of Behavioral Science, Institute of Psychology ; Outstanding Foundation on Humanities and Social Sciences of Young People in Universities of Hebei Education Department[BJ2014101]
WOS Research AreaPsychology ; Behavioral Sciences
WOS SubjectPsychology, Biological ; Behavioral Sciences
WOS IDWOS:000445719800014
PublisherPERGAMON-ELSEVIER SCIENCE LTD
WOS KeywordDrug-addiction ; Sensitization ; Impulsivity ; Mechanisms ; Depression ; Component ; Dopamine ; System ; Scale
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27125
Collection中国科学院行为科学重点实验室
Corresponding AuthorLiu, Xun
Affiliation1.Henan Normal Univ, Coll Educ, Xinxiang, Peoples R China
2.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
3.Dalian Med Univ, Dept Psychol, Dalian, Peoples R China
4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
5.Yanshan Univ, Dept Sports, Qinhuangdao, Peoples R China
Recommended Citation
GB/T 7714
Wei, Shuguang,Zheng, Ya,Li, Qi,et al. Enhanced neural responses to monetary rewards in methamphetamine use disordered individuals compared to healthy controls[J]. PHYSIOLOGY & BEHAVIOR,2018,195:118-127.
APA Wei, Shuguang.,Zheng, Ya.,Li, Qi.,Dai, Weine.,Sun, Jinxiu.,...&Liu, Xun.(2018).Enhanced neural responses to monetary rewards in methamphetamine use disordered individuals compared to healthy controls.PHYSIOLOGY & BEHAVIOR,195,118-127.
MLA Wei, Shuguang,et al."Enhanced neural responses to monetary rewards in methamphetamine use disordered individuals compared to healthy controls".PHYSIOLOGY & BEHAVIOR 195(2018):118-127.
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