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Hexadirectional Modulation of Theta Power in Human Entorhinal Cortex during Spatial Navigation
Chen, Dong1; Kunz, Lukas2; Wang, Wenjing1; Zhang, Hui3; Wang, Wen-Xu1,4; Schulze-Bonhage, Andreas2; Reinacher, Peter C.5; Zhou, Wenjing6; Liang, Shuli7; Axmacher, Nikolai3; Wang, Liang8,9
First AuthorChen, Dong
2018-10-22
Source PublicationCURRENT BIOLOGY
Correspondent Emailnikolai.axmacher@rub.de (n.a.) ; lwang@psych.ac.cn (l.w.)
ISSN0960-9822
SubtypeArticle
Volume28Issue:20Pages:3310-+
Contribution Rank8
Abstract

Grid cells and theta oscillations are fundamental components of the brain's navigation system. Grid cells provide animals [1, 2] and humans [3, 4] with a spatial map of the environment by exhibiting multiple firing fields arranged in a regular grid of equilateral triangles. This unique firing pattern presumably constitutes the neural basis for path integration [5-8] and may also enable navigation in visual and conceptual spaces [9-12]. Theta frequency oscillations are a prominent mesoscopic network phenomenon during navigation in both rodents and humans [13, 14] and encode movement speed [15-17], distance traveled [18], and proximity to spatial boundaries [19]. Whether theta oscillations may also carry a grid-like signal remains elusive, however. Capitalizing on previous fMRI studies revealing a macroscopic proxy of sum grid cell activity in human entorhinal cortex (EC) [20-22], we examined intracranial EEG recordings from the EC of epilepsy patients (n = 9) performing a virtual navigation task. We found that the power of theta oscillations (4-8 Hz) exhibits 6-fold rotational modulation by movement direction, reminiscent of grid cell-like representations detected using fMRI. Modulation of theta power was specific to 6-fold rotational symmetry and to the EC. Hexadirectional modulation of theta power by movement direction only emerged during fast movements, stabilized over the course of the experiment, and showed sensitivity to the environmental boundary. Our results suggest that oscillatory power in the theta frequency range carries an imprint of sum grid cell activity potentially enabled by a common grid orientation of neighboring grid cells [23].

DOI10.1016/j.cub.2018.08.029
Indexed BySCIE
Language英语
Funding OrganizationBMBF ; NIH ; BrainLinks-BrainTools Cluster of Excellence - German Research Foundation (DFG) ; Else Kroner-Fresenius-Stiftung (Bad Homburg, Germany) ; German Ministry for Economic Affairs and Energy (Berlin, Germany) ; Medical Faculty of the University of Freiburg (Freiburg, Germany) ; DFG ; Natural Science Foundation of China ; Beijing Municipal Science and Technology Commission ; CAS Key Laboratory of Mental Health
Funding ProjectBMBF[01GQ1705A] ; NIH[563386] ; BrainLinks-BrainTools Cluster of Excellence - German Research Foundation (DFG)[EXC 1086] ; Else Kroner-Fresenius-Stiftung (Bad Homburg, Germany) ; German Ministry for Economic Affairs and Energy (Berlin, Germany) ; Medical Faculty of the University of Freiburg (Freiburg, Germany) ; DFG[SFB 874/B11] ; DFG[SFB 1280/A02] ; DFG[AX82/3] ; Natural Science Foundation of China[81422024] ; Natural Science Foundation of China[31771255] ; Beijing Municipal Science and Technology Commission[Z171100000117014] ; CAS Key Laboratory of Mental Health[KLMH2018ZK02]
WOS Research AreaBiochemistry & Molecular Biology ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Cell Biology
WOS IDWOS:000448201300032
PublisherCELL PRESS
WOS KeywordGrid Cells ; Visual Space ; Path-integration ; Oscillations ; Memory ; Map ; Hippocampus ; Representations ; Code ; Rat
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27287
Collection中国科学院心理健康重点实验室
Corresponding AuthorAxmacher, Nikolai; Wang, Liang
Affiliation1.Beijing Normal Univ, Sch Syst Sci, Xinjiekouwai Str 19, Beijing 100875, Peoples R China
2.Univ Freiburg, Fac Med, Epilepsy Ctr, Med Ctr, Breisacher Str 64, D-79106 Freiburg, Germany
3.Ruhr Univ Bochum, Fac Psychol, Inst Cognit Neurosci, Dept Neuropsychol, Univ Str 150, D-44801 Bochum, Germany
4.Beijing Normal Univ, IDG McGovern Inst Brain Res, State Key Lab Cognit Neurosci & Learning, Xinjiekouwai Str 19, Beijing 100875, Peoples R China
5.Univ Med Ctr, Stereotact & Funct Neurosurg, Breisacher Str 64, D-79106 Freiburg, Germany
6.Tsinghua Univ, Dept Epilepsy Ctr, Yuquan Hosp, Beijing 100049, Peoples R China
7.Gen Hosp PLA, Affiliated Hosp 1, Dept Neurosurg, 51 Fucheng Rd, Beijing 100048, Peoples R China
8.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
9.CAS Ctr Excellence Brain Sci & Intelligence Techn, 320 Yue Yang Rd, Shanghai 200031, Peoples R China
Recommended Citation
GB/T 7714
Chen, Dong,Kunz, Lukas,Wang, Wenjing,et al. Hexadirectional Modulation of Theta Power in Human Entorhinal Cortex during Spatial Navigation[J]. CURRENT BIOLOGY,2018,28(20):3310-+.
APA Chen, Dong.,Kunz, Lukas.,Wang, Wenjing.,Zhang, Hui.,Wang, Wen-Xu.,...&Wang, Liang.(2018).Hexadirectional Modulation of Theta Power in Human Entorhinal Cortex during Spatial Navigation.CURRENT BIOLOGY,28(20),3310-+.
MLA Chen, Dong,et al."Hexadirectional Modulation of Theta Power in Human Entorhinal Cortex during Spatial Navigation".CURRENT BIOLOGY 28.20(2018):3310-+.
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