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Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing
Wang, Yi1; Li, Zhi1,2; Liu, Wen-hua3; Wei, Xin-hua4; Jiang, Xin-qing4; Lui, Simon S. Y.5; So, Suzanne Ho-Wai6; Cheung, Eric F. C.5; Debbane, Martin7,8,9; Chan, Raymond C. K.1,2
First AuthorWang, Yi
Contribution Rank1

Background: Impairment in facial emotion perception is an important domain of social cognition deficits in schizophrenia. Although impaired facial emotion perception has been found in individuals with negative schizotypy (NS), little is known about the corresponding change in brain functional connectivity. Methods: Sixty-four participants were classified into a high NS group (n = 34) and a low NS group (n = 30) based on their total scores on the Chapman scales for physical and social anhedonia. All participants undertook a facial emotion discrimination functional imaging task that consisted of four emotional valences (angry, fear, happy, and neutral). For univariate analysis, the signal change at the bilateral amygdala was compared for each emotional contrast using SPSS (P < .05). For the functional connectivity analysis, we calculated the beta-series functional connectivity of the bilateral amygdala with the medial prefrontal cortex (mPFC) and compared the group differences in SPM12 (P < .05, small volume family-wise error correction). Results: No significant differences were found between the high and low NS groups in accuracy and reaction time in the facial emotion discrimination task. The high NS group showed reduced brain activations at the amygdala under fearful and neutral conditions. Reduced functional connectivity between the amygdala and the mPFC/dorsal anterior cingulate cortex under the happy and fearful conditions in the high NS group was also found. Conclusions: Our findings suggest that the individuals with high NS showed altered brain activity and functional connectivity at the amygdala during facial emotion processing and provide new evidence for understanding social cognition deficits in at-risk individuals.

KeywordFacial Emotion Discrimination Functional Connectivity Negative Schizotypy Amygdala Mpfc
Indexed BySCIE
Funding ProjectBeijing Municipal Science & Technology Commission[Z161100000216138] ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology ; CAS/SAFEA International Partnership Programme for Creative Research Teams[Y2CX131003] ; National Science Fund China[31400884] ; China Scholarship Council
WOS KeywordClinical High-risk ; Psychosis-proneness ; Affect Recognition ; Social Cognition ; Psychometric Schizotypy ; Organizing Framework ; Brain Structure ; Schizophrenia ; Individuals ; Metaanalysis
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000448172600005
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWang, Yi
Affiliation1.Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Guangzhou Med Univ, Fac Hlth Management, Guangzhou, Guangdong, Peoples R China
4.Guangzhou First Peoples Hosp, Dept Radiol, Guangzhou, Guangdong, Peoples R China
5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
6.Chinese Univ Hong Kong, Dept Psychol, Hong Kong, Hong Kong, Peoples R China
7.Univ Geneva, Fac Psychol & Educ Sci, Dev Clin Psychol Res Unit, Geneva, Switzerland
8.Univ Geneva, Sch Med, Dev NeuroImaging & Psychopathol Lab, Dept Psychiat, Geneva, Switzerland
9.UCL, Res Dept Clin Educ & Hlth Psychol, London, England
First Author Affilication认知与发展心理学研究室
Corresponding Author Affilication认知与发展心理学研究室
Recommended Citation
GB/T 7714
Wang, Yi,Li, Zhi,Liu, Wen-hua,et al. Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing[J]. SCHIZOPHRENIA BULLETIN,2018,44:S491-S500.
APA Wang, Yi.,Li, Zhi.,Liu, Wen-hua.,Wei, Xin-hua.,Jiang, Xin-qing.,...&Chan, Raymond C. K..(2018).Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing.SCHIZOPHRENIA BULLETIN,44,S491-S500.
MLA Wang, Yi,et al."Negative Schizotypy and Altered Functional Connectivity During Facial Emotion Processing".SCHIZOPHRENIA BULLETIN 44(2018):S491-S500.
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