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Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults
Huo, Lijuan1,2; Zheng, Zhiwei1,2; Li, Jin1,2; Wan, Wenyu1,2; Cui, Xiaoyu1,2; Chen, Shuyuan1,2; Wang, Wei1,2; Li, Juan1,2
2018-10-17
发表期刊FRONTIERS IN AGING NEUROSCIENCE
ISSN1663-4365
卷号10页码:11
摘要Background: Executive function tends to decline as people age. Transcranial direct current stimulation (tDCS) is assumed to have beneficial effects on various cognitive functions. Some prior investigations have shown that repeated sessions of tDCS enhance the executive function performance of healthy elderly people by mediating cognitive training gains. However, studies of the effect of long-term stimulation on executive function without cognitive training are absent. Objective: The purpose of this study was to explore whether the executive function of healthy older adults could be enhanced with long-term tDCS alone applied on the prefrontal cortex. Methods: Sixty-five cognitively normal older adults were enrolled and randomly assigned to two groups: an anodal tDCS group and a sham tDCS group. The participants in the two groups received anodal stimulation or sham stimulation over the left dorsolateral prefrontal lobe, for 30 min per day for 10 consecutive days. Executive function was tested before stimulation, immediately after stimulation and 3 months after stimulation. Three core components of executive function were tested using a two-back task for updating, a flanker task for inhibition, and a switching task for shifting. Results: Across the three tasks, we failed to discover any differences between the anodal and sham stimulation. Moreover, we found no statistically significant stimulation effect in the follow-up session. Conclusion: Our study does not support the assumption that multiple sessions of tDCS that are independent of cognitive training have a beneficial effect on executive function in healthy older adults, presumably because the effect of the stimulation lies in its amplification of training gains. It indicates that combining traditional cognitive training methods with brain stimulation may be a better approach to improve older adults' executive function.
关键词transcranial direct current stimulation executive function dorsolateral prefrontal cortex older adults follow-up effect
DOI10.3389/fnagi.2018.00298
语种英语
项目资助者National Natural Science Foundation of China ; National Key Research and Development Program of China ; Beijing Municipal Science & Technology Commission ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program ; CAS Key Laboratory of Mental Health, Institute of Psychology
资助项目National Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31470998] ; National Natural Science Foundation of China[31271108] ; National Natural Science Foundation of China[31200847] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[31700974] ; National Key Research and Development Program of China[2016YFC1305900] ; Beijing Municipal Science & Technology Commission[Z171100000117006] ; Beijing Municipal Science & Technology Commission[Z171100008217006] ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program[TSS-2015-06] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2014ZK02]
WOS研究方向Geriatrics & Gerontology ; Neurosciences & Neurology
WOS类目Geriatrics & Gerontology ; Neurosciences
WOS记录号WOS:000447506800001
出版者FRONTIERS MEDIA SA
关键词[WOS]NONINVASIVE BRAIN-STIMULATION ; DORSOLATERAL PREFRONTAL CORTEX ; WORKING-MEMORY ; COGNITIVE CONTROL ; MOTOR CORTEX ; CORTICAL PLASTICITY ; ALZHEIMERS-DISEASE ; INTERINDIVIDUAL VARIABILITY ; PARKINSONS-DISEASE ; SINGLE-SESSION
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27310
专题中国科学院心理健康重点实验室
通讯作者Li, Juan
作者单位1.Chinese Acad Sci, Ctr Aging Psychol, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Huo, Lijuan,Zheng, Zhiwei,Li, Jin,et al. Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10:11.
APA Huo, Lijuan.,Zheng, Zhiwei.,Li, Jin.,Wan, Wenyu.,Cui, Xiaoyu.,...&Li, Juan.(2018).Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults.FRONTIERS IN AGING NEUROSCIENCE,10,11.
MLA Huo, Lijuan,et al."Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults".FRONTIERS IN AGING NEUROSCIENCE 10(2018):11.
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