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Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults
Huo, Lijuan1,2; Zheng, Zhiwei1,2; Li, Jin1,2; Wan, Wenyu1,2; Cui, Xiaoyu1,2; Chen, Shuyuan1,2; Wang, Wei1,2; Li, Juan1,2
First AuthorHuo, Lijuan
2018-10-17
Source PublicationFRONTIERS IN AGING NEUROSCIENCE
Correspondent Emailjuan li lijuan@psych.ac.cn
ISSN1663-4365
SubtypeArticle
Volume10Pages:11
Contribution Rank1
Abstract

Background: Executive function tends to decline as people age. Transcranial direct current stimulation (tDCS) is assumed to have beneficial effects on various cognitive functions. Some prior investigations have shown that repeated sessions of tDCS enhance the executive function performance of healthy elderly people by mediating cognitive training gains. However, studies of the effect of long-term stimulation on executive function without cognitive training are absent. Objective: The purpose of this study was to explore whether the executive function of healthy older adults could be enhanced with long-term tDCS alone applied on the prefrontal cortex. Methods: Sixty-five cognitively normal older adults were enrolled and randomly assigned to two groups: an anodal tDCS group and a sham tDCS group. The participants in the two groups received anodal stimulation or sham stimulation over the left dorsolateral prefrontal lobe, for 30 min per day for 10 consecutive days. Executive function was tested before stimulation, immediately after stimulation and 3 months after stimulation. Three core components of executive function were tested using a two-back task for updating, a flanker task for inhibition, and a switching task for shifting. Results: Across the three tasks, we failed to discover any differences between the anodal and sham stimulation. Moreover, we found no statistically significant stimulation effect in the follow-up session. Conclusion: Our study does not support the assumption that multiple sessions of tDCS that are independent of cognitive training have a beneficial effect on executive function in healthy older adults, presumably because the effect of the stimulation lies in its amplification of training gains. It indicates that combining traditional cognitive training methods with brain stimulation may be a better approach to improve older adults' executive function.

KeywordTranscranial Direct Current Stimulation Executive Function Dorsolateral Prefrontal Cortex Older Adults Follow-up Effect
DOI10.3389/fnagi.2018.00298
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Key Research and Development Program of China ; Beijing Municipal Science & Technology Commission ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program ; CAS Key Laboratory of Mental Health, Institute of Psychology
Funding ProjectNational Natural Science Foundation of China[31671157] ; National Natural Science Foundation of China[31470998] ; National Natural Science Foundation of China[31271108] ; National Natural Science Foundation of China[31200847] ; National Natural Science Foundation of China[31711530157] ; National Natural Science Foundation of China[31700974] ; National Key Research and Development Program of China[2016YFC1305900] ; Beijing Municipal Science & Technology Commission[Z171100000117006] ; Beijing Municipal Science & Technology Commission[Z171100008217006] ; Pioneer Initiative of the Chinese Academy of Sciences, Feature Institutes Program[TSS-2015-06] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2014ZK02]
WOS Research AreaGeriatrics & Gerontology ; Neurosciences & Neurology
WOS SubjectGeriatrics & Gerontology ; Neurosciences
WOS IDWOS:000447506800001
PublisherFRONTIERS MEDIA SA
WOS KeywordNoninvasive Brain-stimulation ; Dorsolateral Prefrontal Cortex ; Working-memory ; Cognitive Control ; Motor Cortex ; Cortical Plasticity ; Alzheimers-disease ; Interindividual Variability ; Parkinsons-disease ; Single-session
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27310
Collection中国科学院心理健康重点实验室
Corresponding AuthorLi, Juan
Affiliation1.Chinese Acad Sci, Ctr Aging Psychol, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Huo, Lijuan,Zheng, Zhiwei,Li, Jin,et al. Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults[J]. FRONTIERS IN AGING NEUROSCIENCE,2018,10:11.
APA Huo, Lijuan.,Zheng, Zhiwei.,Li, Jin.,Wan, Wenyu.,Cui, Xiaoyu.,...&Li, Juan.(2018).Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults.FRONTIERS IN AGING NEUROSCIENCE,10,11.
MLA Huo, Lijuan,et al."Long-Term Transcranial Direct Current Stimulation Does Not Improve Executive Function in Healthy Older Adults".FRONTIERS IN AGING NEUROSCIENCE 10(2018):11.
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