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Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study
Wang, Shao-Nan1; Ding, Yong-Sheng1; Ma, Xiao-Jie1; Zhao, Cheng-Bowen1; Lin, Ming-Xuan1; Luo, Jing1; Jiang, Yi-Nan1; He, Shuai1; Guo, Jian-You2; Shi, Jin-Li1
2018-09-01
发表期刊MOLECULES
ISSN1420-3049
卷号23期号:9页码:21
摘要Zhi zhu xiang (ZZX for short) is the root and rhizome of Valeriana jatamansi Jones, which is a Traditional Chinese Medicine (TCM) used to treat various mood disorders for more than 2000 years, especially anxiety. The aim of the present work was to identify the bioactive chemical markers in Zhi zhu xiang improving anxiety in rats by a fingerprint-efficacy study. More specifically, the chemical fingerprint of ZZX samples collected from 10 different regions was determined by High Performance Liquid Chromatography (HPLC) and the similarity analyses were calculated based on 10 common characteristic peaks. The anti-anxiety effect of ZZX on empty bottle stimulated rats was examined through the Open Field Test (OFT) and the Elevated Plus Maze Test (EPM). Then we measured the concentration of CRF, ACTH, and CORT in rat's plasma by the enzyme-linked immune sorbent assay (ELISA) kit, while the concentration of monoamine and metabolites (NE, DA, DOPAC, HVA, 5-HT, 5-HIAA) in the rat's cerebral cortex and hippocampus was analysed by HPLC coupled with an Electrochemical Detector. At last, the fingerprint-efficacy study between chemical fingerprint and anti-anxiety effect of ZZX was accomplished by partial least squares regression (PLSR). As a result, we screened out four compounds (hesperidin, isochlorogenic acid A, isochlorogenic acid B and isochlorogenic acid C) as the bioactive chemical markers for the anti-anxiety effect of ZZX. The fingerprint-efficacy study we established might provide a feasible way and some elicitation for the identification of the bioactive chemical markers for TCM.
关键词anti-anxiety Valeriana jatamansi Jones fingerprint-efficacy relationship PLSR
DOI10.3390/molecules23092329
语种英语
项目资助者National Natural Science Foundation of China
资助项目National Natural Science Foundation of China[81673560]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
WOS类目Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS记录号WOS:000447365100240
出版者MDPI
关键词[WOS]TAIL SUSPENSION TEST ; MENTAL-DISORDERS ; STRESS-RESPONSE ; FERULIC ACID ; MICE ; ANTIDEPRESSANT ; BEHAVIOR ; BENZODIAZEPINES ; GLUCOCORTICOIDS ; INVOLVEMENT
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27311
专题中国科学院心理健康重点实验室
通讯作者Guo, Jian-You; Shi, Jin-Li
作者单位1.Beijing Univ Chinese Med, Sch Chinese Mat Medica, 11A North Third Ring East Rd, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China
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Wang, Shao-Nan,Ding, Yong-Sheng,Ma, Xiao-Jie,et al. Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study[J]. MOLECULES,2018,23(9):21.
APA Wang, Shao-Nan.,Ding, Yong-Sheng.,Ma, Xiao-Jie.,Zhao, Cheng-Bowen.,Lin, Ming-Xuan.,...&Shi, Jin-Li.(2018).Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study.MOLECULES,23(9),21.
MLA Wang, Shao-Nan,et al."Identification of Bioactive Chemical Markers in Zhi zhu xiang Improving Anxiety in Rat by Fingerprint-Efficacy Study".MOLECULES 23.9(2018):21.
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