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Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews
Shen, Fang1,2; Qi, Keke3; Duan, Ying1,2; Li, Yonghui1,2; Liang, Jing1,2; Meng, Xiaolu1,2; Li, Ming4; Sui, Nan1,2
First AuthorShen, Fang
2018-10-01
Source PublicationJOURNAL OF PSYCHOPHARMACOLOGY
Correspondent Emailsuin@psych.ac.cn
ISSN0269-8811
SubtypeArticle
Volume32Issue:10Pages:1141-1149
Contribution Rank1
Abstract

Background: Anhedonia is a hallmark symptom in major depression that reflects deficits in hedonic capacity and it is also linked to motivation for reward. However, studies of the features of motivation in depressed tree shrews are rather sparse. Aims: The study aimed to investigate the core feature of depression including lack of interest, motivation reduction, and social avoidance in tree shrews. Furthermore, the effects of the treatment using clomipramine on these depression-like behaviors were assessed. Methods: The paradigm of chronic social defeat in tree shrews was used to evaluate the core feature of depression through examining their sucrose preference, break-point for reward, and social interaction. Results: The results showed that social defeat lowered the curves of the sucrose preference and the break-point, as well as decreased social interaction. The results suggested that the subordinate animals exhibited interest loss, motivational reduction, and social avoidance. After oral treatment with clomipramine (50 mg/kg/day) for four weeks, most of the depression-like behaviors were reversed, whereas the motivational reduction was not clearly affected. Notably, the motivational reduction appeared obviously during the first week after the social defeat, and the conventional tricyclic antidepressant clomipramine did not reverse the reduced motivation. Conclusions: These findings imply that motivational variation might be applied as a more sensitive behavioral index in subordinate animals and could furthermore be used to evaluate potential agents as antidepressants.

KeywordSocial Defeat Anhedonia Motivation Tree Shrews Depression-like Behaviors
DOI10.1177/0269881118793560
Indexed BySCIE
Language英语
Funding OrganizationNational Natural Science Foundation of China ; National Basic Research Programme ; National Natural Science Foundation Major Research Plan program ; Starting Foundation for Doctoral Research of Anhui University ; Foundation for Planning of Philosophy and Social Sciences of Anhui Province ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
Funding ProjectNational Natural Science Foundation of China[31500893] ; National Natural Science Foundation of China[31170988] ; National Basic Research Programme[2015CB553501] ; National Natural Science Foundation Major Research Plan program[91332115] ; Starting Foundation for Doctoral Research of Anhui University[J10113190102] ; Foundation for Planning of Philosophy and Social Sciences of Anhui Province[AHSKQ2016D62] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS SubjectClinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS IDWOS:000446696100012
PublisherSAGE PUBLICATIONS LTD
WOS KeywordChronic Mild Stress ; Progressive-ratio Schedules ; Chronic Psychosocial Stress ; Open-field Activity ; Translational Neuroscience ; Tricyclic Antidepressants ; Major Depression ; Animal-models ; Life Events ; Dopamine
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27313
Collection中国科学院心理健康重点实验室
Corresponding AuthorSui, Nan
Affiliation1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Anhui Univ, Dept Philosophy, Hefei, Anhui, Peoples R China
4.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
Recommended Citation
GB/T 7714
Shen, Fang,Qi, Keke,Duan, Ying,et al. Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2018,32(10):1141-1149.
APA Shen, Fang.,Qi, Keke.,Duan, Ying.,Li, Yonghui.,Liang, Jing.,...&Sui, Nan.(2018).Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews.JOURNAL OF PSYCHOPHARMACOLOGY,32(10),1141-1149.
MLA Shen, Fang,et al."Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews".JOURNAL OF PSYCHOPHARMACOLOGY 32.10(2018):1141-1149.
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