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Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews
Shen, Fang1,2; Qi, Keke3; Duan, Ying1,2; Li, Yonghui1,2; Liang, Jing1,2; Meng, Xiaolu1,2; Li, Ming4; Sui, Nan1,2
2018-10-01
发表期刊JOURNAL OF PSYCHOPHARMACOLOGY
ISSN0269-8811
卷号32期号:10页码:1141-1149
摘要Background: Anhedonia is a hallmark symptom in major depression that reflects deficits in hedonic capacity and it is also linked to motivation for reward. However, studies of the features of motivation in depressed tree shrews are rather sparse. Aims: The study aimed to investigate the core feature of depression including lack of interest, motivation reduction, and social avoidance in tree shrews. Furthermore, the effects of the treatment using clomipramine on these depression-like behaviors were assessed. Methods: The paradigm of chronic social defeat in tree shrews was used to evaluate the core feature of depression through examining their sucrose preference, break-point for reward, and social interaction. Results: The results showed that social defeat lowered the curves of the sucrose preference and the break-point, as well as decreased social interaction. The results suggested that the subordinate animals exhibited interest loss, motivational reduction, and social avoidance. After oral treatment with clomipramine (50 mg/kg/day) for four weeks, most of the depression-like behaviors were reversed, whereas the motivational reduction was not clearly affected. Notably, the motivational reduction appeared obviously during the first week after the social defeat, and the conventional tricyclic antidepressant clomipramine did not reverse the reduced motivation. Conclusions: These findings imply that motivational variation might be applied as a more sensitive behavioral index in subordinate animals and could furthermore be used to evaluate potential agents as antidepressants.
关键词Social defeat anhedonia motivation tree shrews depression-like behaviors
DOI10.1177/0269881118793560
语种英语
项目资助者National Natural Science Foundation of China ; National Basic Research Programme ; National Natural Science Foundation Major Research Plan program ; Starting Foundation for Doctoral Research of Anhui University ; Foundation for Planning of Philosophy and Social Sciences of Anhui Province ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
资助项目National Natural Science Foundation of China[31500893] ; National Natural Science Foundation of China[31170988] ; National Basic Research Programme[2015CB553501] ; National Natural Science Foundation Major Research Plan program[91332115] ; Starting Foundation for Doctoral Research of Anhui University[J10113190102] ; Foundation for Planning of Philosophy and Social Sciences of Anhui Province[AHSKQ2016D62] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000446696100012
出版者SAGE PUBLICATIONS LTD
关键词[WOS]CHRONIC MILD STRESS ; PROGRESSIVE-RATIO SCHEDULES ; CHRONIC PSYCHOSOCIAL STRESS ; OPEN-FIELD ACTIVITY ; TRANSLATIONAL NEUROSCIENCE ; TRICYCLIC ANTIDEPRESSANTS ; MAJOR DEPRESSION ; ANIMAL-MODELS ; LIFE EVENTS ; DOPAMINE
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27313
专题中国科学院心理健康重点实验室
通讯作者Sui, Nan
作者单位1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Anhui Univ, Dept Philosophy, Hefei, Anhui, Peoples R China
4.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
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Shen, Fang,Qi, Keke,Duan, Ying,et al. Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2018,32(10):1141-1149.
APA Shen, Fang.,Qi, Keke.,Duan, Ying.,Li, Yonghui.,Liang, Jing.,...&Sui, Nan.(2018).Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews.JOURNAL OF PSYCHOPHARMACOLOGY,32(10),1141-1149.
MLA Shen, Fang,et al."Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews".JOURNAL OF PSYCHOPHARMACOLOGY 32.10(2018):1141-1149.
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