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Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews | |
Shen, Fang1,2; Qi, Keke3; Duan, Ying1,2; Li, Yonghui1,2; Liang, Jing1,2; Meng, Xiaolu1,2; Li, Ming4; Sui, Nan1,2 | |
第一作者 | Shen, Fang |
通讯作者邮箱 | suin@psych.ac.cn |
心理所单位排序 | 1 |
摘要 | Background: Anhedonia is a hallmark symptom in major depression that reflects deficits in hedonic capacity and it is also linked to motivation for reward. However, studies of the features of motivation in depressed tree shrews are rather sparse. Aims: The study aimed to investigate the core feature of depression including lack of interest, motivation reduction, and social avoidance in tree shrews. Furthermore, the effects of the treatment using clomipramine on these depression-like behaviors were assessed. Methods: The paradigm of chronic social defeat in tree shrews was used to evaluate the core feature of depression through examining their sucrose preference, break-point for reward, and social interaction. Results: The results showed that social defeat lowered the curves of the sucrose preference and the break-point, as well as decreased social interaction. The results suggested that the subordinate animals exhibited interest loss, motivational reduction, and social avoidance. After oral treatment with clomipramine (50 mg/kg/day) for four weeks, most of the depression-like behaviors were reversed, whereas the motivational reduction was not clearly affected. Notably, the motivational reduction appeared obviously during the first week after the social defeat, and the conventional tricyclic antidepressant clomipramine did not reverse the reduced motivation. Conclusions: These findings imply that motivational variation might be applied as a more sensitive behavioral index in subordinate animals and could furthermore be used to evaluate potential agents as antidepressants. |
关键词 | Social Defeat Anhedonia Motivation Tree Shrews Depression-like Behaviors |
2018-10-01 | |
DOI | 10.1177/0269881118793560 |
发表期刊 | JOURNAL OF PSYCHOPHARMACOLOGY |
ISSN | 0269-8811 |
卷号 | 32期号:10页码:1141-1149 |
收录类别 | SCI ; SSCI |
出版者 | SAGE PUBLICATIONS LTD |
WOS关键词 | Chronic Mild Stress ; Progressive-ratio Schedules ; Chronic Psychosocial Stress ; Open-field Activity ; Translational Neuroscience ; Tricyclic Antidepressants ; Major Depression ; Animal-models ; Life Events ; Dopamine |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
WOS类目 | Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
WOS记录号 | WOS:000446696100012 |
WOS分区 | Q1 |
资助机构 | National Natural Science Foundation of China ; National Basic Research Programme ; National Natural Science Foundation Major Research Plan program ; Starting Foundation for Doctoral Research of Anhui University ; Foundation for Planning of Philosophy and Social Sciences of Anhui Province ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/27313 |
专题 | 中国科学院心理健康重点实验室 |
通讯作者 | Sui, Nan |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Anhui Univ, Dept Philosophy, Hefei, Anhui, Peoples R China 4.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA |
第一作者单位 | 中国科学院心理健康重点实验室 |
通讯作者单位 | 中国科学院心理健康重点实验室 |
推荐引用方式 GB/T 7714 | Shen, Fang,Qi, Keke,Duan, Ying,et al. Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews[J]. JOURNAL OF PSYCHOPHARMACOLOGY,2018,32(10):1141-1149. |
APA | Shen, Fang.,Qi, Keke.,Duan, Ying.,Li, Yonghui.,Liang, Jing.,...&Sui, Nan.(2018).Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews.JOURNAL OF PSYCHOPHARMACOLOGY,32(10),1141-1149. |
MLA | Shen, Fang,et al."Differential effects of clomipramine on depression-like behaviors induced by the chronic social defeat paradigm in tree shrews".JOURNAL OF PSYCHOPHARMACOLOGY 32.10(2018):1141-1149. |
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