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Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative
Docherty, Anna R.1,2,3; Fonseca-Pedrero, Eduardo4; Debbane, Martin5,6; Chan, Raymond C. K.7,8; Linscott, Richard J.9; Jonas, Katherine G.10; Cicero, David C.11; Green, Melissa J.12; Simms, Leonard J.13; Mason, Oliver14; Watson, David15; Ettinger, Ulrich16; Waszczuk, Monika10; Rapp, Alexander17; Grant, Phillip18,19; Kotov, Roman10; De Young, Colin G.20; Ruggero, Camilo J.21; Eaton, Nicolas R.22; Krueger, Robert F.20; Patrick, Christopher23; Hopwood, Christopher24; O'Neill, F. Anthony25; Zald, David H.26,27; Conway, Christopher C.28; Adkins, Daniel E.1,29; Waldman, Irwin D.30; van Os, Jim31,32,33; Sullivan, Patrick F.34,35; Anderson, John S.1; Shabalin, Andrey A.1; Sponheim, Scott R.20; Taylor, Stephan F.36; Grazioplene, Rachel G.37; Bacanu, Silviu A.2; Bigdeli, Tim B.2,3,38; Haenschel, Corinna39; Malaspina, Dolores40; Gooding, Diane C.41; Nicodemus, Kristin42; Schultze-Lutter, Frauke43; Barrantes-Vidal, Neus44,45,46; Mohr, Christine47; Carpenter, William T.48; Cohen, Alex S.49
First AuthorDocherty, Anna R.
Contribution Rank7

The latent structure of schizotypy and psychosis-spectrum symptoms remains poorly understood. Furthermore, molecular genetic substrates are poorly defined, largely due to the substantial resources required to collect rich phenotypic data across diverse populations. Sample sizes of phenotypic studies are often insufficient for advanced structural equation modeling approaches. In the last 50 years, efforts in both psychiatry and psychological science have moved toward (1) a dimensional model of psychopathology (eg, the current Hierarchical Taxonomy of Psychopathology [HiTOP] initiative), (2) an integration of methods and measures across traits and units of analysis (eg, the RDoC initiative), and (3) powerful, impactful study designs maximizing sample size to detect subtle genomic variation relating to complex traits (the Psychiatric Genomics Consortium [PGC]). These movements are important to the future study of the psychosis spectrum, and to resolving heterogeneity with respect to instrument and population. The International Consortium of Schizotypy Research is composed of over 40 laboratories in 12 countries, and to date, members have compiled a body of schizotypy- and psychosis-related phenotype data from more than 30 000 individuals. It has become apparent that compiling data into a protected, relational database and crowdsourcing analytic and data science expertise will result in significant enhancement of current research on the structure and biological substrates of the psychosis spectrum. The authors present a data-sharing infrastructure similar to that of the PGC, and a resource-sharing infrastructure similar to that of HiTOP. This report details the rationale and benefits of the phenotypic data collective and presents an open invitation for participation.

KeywordData Sharing Schizotypy Schizotypal Psychos Is Schizophrenia Phenotype Genetic Icsr Hitop
Indexed BySCIE
WOS KeywordResearch Domain Criteria ; Genome-wide Association ; Syndrome Scale Panss ; Negative Syndrome ; Schizotypal Symptoms ; Increases Accuracy ; General-population ; Bipolar Disorder ; Complex Diseases ; Risk Prediction
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000448172600002
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorDocherty, Anna R.
Affiliation1.Univ Utah, Sch Med, Dept Psychiat, 501 Chipeta Way, Salt Lake City, UT 84110 USA
2.Virginia Commonwealth Univ, Sch Med, Virginia Inst Psychiat & Behav Genet, Richmond, VA USA
3.Virginia Commonwealth Univ, Sch Med, Dept Psychiat, Richmond, VA USA
4.Univ La Rioja, Dept Psychiat, Oviedo, Spain
5.UCL, Res Dept Clin Educ & Hlth Psychol, London, England
6.Univ Geneva, Psychol & Educ Sci, Geneva, Switzerland
7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
8.Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
9.Univ Otago, Dept Psychol, Dunedin, New Zealand
10.Stony Brook Sch Med, Dept Psychiat, Stony Brook, NY USA
11.Univ Hawaii Manoa, Dept Psychol, Honolulu, HI 96822 USA
12.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia
13.Univ Buffalo State Univ New York, Dept Psychol, Buffalo, NY USA
14.Univ Surrey, Dept Psychol, Guildford, Surrey, England
15.Univ Notre Dame, Dept Psychol, Notre Dame, IN 46556 USA
16.Univ Bonn, Dept Psychol, Bonn, Germany
17.Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany
18.Justus Liebig Univ Giessen, Dept Psychol, Giessen, Germany
19.Univ Appl Sci, TH Mittelhessen, Giessen, Germany
20.Univ Minnesota, Dept Psychol, Minneapolis, MN USA
21.Univ North Texas, Dept Psychol, Denton, TX USA
22.SUNY Stony Brook, Dept Psychol, Stony Brook, NY 11794 USA
23.Florida State Univ, Dept Psychol, Tallahassee, FL 32306 USA
24.Univ Calif Davis, Dept Psychol, Davis, CA 95616 USA
25.Queens Univ Belfast, Ctr Publ Hlth, Inst Clin Sci, Belfast, Antrim, North Ireland
26.Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA
27.Vanderbilt Univ, Dept Psychiat, 221 Kirkland Hall, Nashville, TN 37235 USA
28.Coll William & Mary, Dept Psychol, Williamsburg, VA 23185 USA
29.Univ Utah, Dept Sociol, Salt Lake City, UT 84110 USA
30.Emory Univ, Dept Psychol, Atlanta, GA 30322 USA
31.Maastricht Univ, Dept Psychiat & Psychol, Med Ctr, Maastricht, Netherlands
32.Kings Coll London, Inst Psychiat, Dept Psychosis Studies, Kings Hlth Partners, London, England
33.Univ Med Ctr, Brain Ctr Rudolf Magnus Inst, Dept Psychiat, Utrecht, Netherlands
34.Univ North Carolina Chapel Hill, Dept Psychiat, Chapel Hill, NC USA
35.Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
36.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
37.Yale Univ, Dept Psychol, New Haven, CT USA
38.SUNY Downstate Med Ctr, Dept Psychiat & Behav Sci, Brooklyn, England
39.City Univ London, Dept Psychol, London, England
40.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
41.Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA
42.Univ Edinburgh, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland
43.Heinrich Heine Univ, Dept Psychiat & Psychotherapy, Dusseldorf, Germany
44.Univ Autonoma Barcelona, Dept Clin Psychol, Barcelona, Spain
45.Univ North Carolina Greensboro, Ctr Biomed Res, Greensboro, NC USA
46.St Pere Claver Fundacio Sanitaria, Barcelona, Spain
47.Univ Lausanne, Inst Psychol, Lausanne, Switzerland
48.Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA
49.Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA
Recommended Citation
GB/T 7714
Docherty, Anna R.,Fonseca-Pedrero, Eduardo,Debbane, Martin,et al. Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative[J]. SCHIZOPHRENIA BULLETIN,2018,44:S460-S467.
APA Docherty, Anna R..,Fonseca-Pedrero, Eduardo.,Debbane, Martin.,Chan, Raymond C. K..,Linscott, Richard J..,...&Cohen, Alex S..(2018).Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative.SCHIZOPHRENIA BULLETIN,44,S460-S467.
MLA Docherty, Anna R.,et al."Enhancing Psychosis-Spectrum Nosology Through an International Data Sharing Initiative".SCHIZOPHRENIA BULLETIN 44(2018):S460-S467.
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