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Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder
Kong, Qing-Mei1,2,3; Qiao, Hong1,2,3; Liu, Chao-Zhong1,2,3; Zhang, Ping4; Li, Ke5; Wang, Li1,2,3; Li, Ji-Tao1,2,3; Su, Yun'Ai1,2,3; Li, Ke-Qing4; Yan, Chao-Gan6; Mitchell, Philip B.7,8; Si, Tian-Mei1,2,3
First AuthorKong, Qing-Mei
2018-11-01
Source PublicationCNS NEUROSCIENCE & THERAPEUTICS
Correspondent Emailsi.tian-mei@163.com
ISSN1755-5930
SubtypeArticle
Volume24Issue:11Pages:1063-1072
Contribution Rank6
Abstract

Objective: Growing evidence has implicated dysfunction of the thalamus and its projection cortical targets in depression. However, the anatomical specificity of thalamo-cortical connectivity in major depressive disorder (MDD) remains unknown due to the regional heterogeneity of the thalamus and limited methods to examine this. Methods: Resting-state fMRI was collected on 70 MDD patients and 70 healthy controls. The thalamus was parcellated based on connectivity with six predefined cortical regions of interest (ROIs). The segmented thalamic nuclei were used as seeds to map connectivity with the rest of the whole brain. The cortical-to-thalamus connectivity values and thalamus-based connectivity maps were compared between groups. Results: The cortical ROIs demonstrated correlations with spatially distinct zones within the thalamus. We found a trend toward reduced parietal ROI-to-thalamus connectivity in MDD. Importantly, MDD patients demonstrated reduced connectivity between prefrontal and parietal thalamus ROIs and bilateral middle frontal gyrus (MFG) and the right posterior default mode network (DMN) and between the prefrontal and motor thalamus ROIs and lateral temporal regions. Conversely, increased connectivity emerged between the motor thalamus ROI and right MFG and right medial frontal gyrus/anterior cingulate; between motor/somatosensory thalamus ROIs and right posterior DMN; between prefrontal/somatosensory thalamus ROIs and cerebellum; and between the parietal thalamus ROI and left insula. Conclusions: This study is the first to examine the anatomical specificity of thalamo-cortical connectivity disturbances in MDD. Subjects with MDD demonstrated altered thalamo-cortical connectivity characterized by a complex pattern of region-dependent hypo- or hyperconnectivity. We therefore speculate that selectively modulating the connectivity of thalamo-cortical circuitry may be a potential novel therapeutic mechanism for MDD.

KeywordCortex Functional Connectivity Major Depressive Disorder Resting-state Fmri Thalamus
DOI10.1111/cns.12831
Indexed BySCIE
Language英语
Funding OrganizationNational Natural Science Foundation of China ; Beijing Municipal Science and Technology Project ; Capital Foundation of Medicine Research and Development ; National Key Basic R & D Program of China ; National Key Basic R&D Program of China
Funding ProjectNational Natural Science Foundation of China[81630031] ; Beijing Municipal Science and Technology Project[Z171100000117016] ; Capital Foundation of Medicine Research and Development[2016-1-4111] ; National Key Basic R & D Program of China[2013CB531305] ; National Key Basic R&D Program of China[2015BAI13B01]
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy
WOS SubjectNeurosciences ; Pharmacology & Pharmacy
WOS IDWOS:000447199600007
PublisherWILEY
WOS KeywordAlternating-current Stimulation ; Mood-regulating Circuit ; Structural Connectivity ; Magnetic-resonance ; Human Thalamus ; Dysfunction ; Cortex ; Fmri ; Mri ; Schizophrenia
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27318
Collection中国科学院行为科学重点实验室
Corresponding AuthorYan, Chao-Gan; Si, Tian-Mei
Affiliation1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing, Peoples R China
2.Peking Univ, Minist Hlth, Natl Clin Res Ctr Mental Hlth Disorders, Beijing, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
4.Sixth Hosp Hebei Prov, Shijiazhuang, Hebei, Peoples R China
5.306 Hosp Peoples Liberat Army, Dept Radiol, Beijing, Peoples R China
6.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China
7.Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia
8.Black Dog Inst, Sydney, NSW, Australia
Recommended Citation
GB/T 7714
Kong, Qing-Mei,Qiao, Hong,Liu, Chao-Zhong,et al. Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder[J]. CNS NEUROSCIENCE & THERAPEUTICS,2018,24(11):1063-1072.
APA Kong, Qing-Mei.,Qiao, Hong.,Liu, Chao-Zhong.,Zhang, Ping.,Li, Ke.,...&Si, Tian-Mei.(2018).Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder.CNS NEUROSCIENCE & THERAPEUTICS,24(11),1063-1072.
MLA Kong, Qing-Mei,et al."Aberrant intrinsic functional connectivity in thalamo-cortical networks in major depressive disorder".CNS NEUROSCIENCE & THERAPEUTICS 24.11(2018):1063-1072.
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