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Alternative TitleSelf-referential impairments in schizophrenia spectrum disorders
杨晗雪1,2; 王玉娜3; 陈楚侨1,2
Conference Name第二十一届全国心理学学术会议
Source Publication摘要集-第二十一届全国心理学学术会议
Conference Date10.30-11.2
Conference Place北京
Contribution Rank1



Other Abstract

Abstract:Schizophrenia is associated with changes of self and related disorders. However, theunderlying mechanism of self impairment in schizophrenia is still not fully known. In thisresearch, we reviewed the concept of self from perspectives of psychology,psychiatry and cognitive neuroscience. In particular, we examined self-referential process and how these constructs might relate to schizophrenia. Given that the concept of spectrum can help better understand ofpathology of schizophrenia, and provide relevant information for early detection andprevention of schizophrenia, this research focused on both the behavioral and neuralperformances of self-related process in the schizophrenia spectrum.

In the behaviour study, we used the typical self-reference effect task to examine self-referentialprocess defects in schizophrenia patients and individuals with schizotypal personalityfeatures (SPD). We also explored the relationship between insight and self-reference processin schizophrenia. Results indicated that schizophrenia patients group and healthy controlgroup both showed the self-reference effect. However, the magnitude of self-referenceeffect in schizophrenia patients was significantly less than the healthy control group. Thesefindings suggested that schizophrenia exhibited a certain degree of damage in self-referenceprocess. Insight seemed to be related with the scope of self-concept in schizophrenia, ininsight-reserved group, mother and self-related stimuli have the same level of memoryperformance, both significantly better than Sun Zhongshan related stimuli, while in theinsight defected group, mother and Sun Zhongshan have the comparable level of memoryperformance, both worse than the self-referential stimuli.In the neural mechanism study, we adopted fMRI paradigm to explore the neural responses ofself-referential process in schizophrenia patients and SPD. Schizophrenia patients showedabnormal hyperactivity across the conditions of self-referential process task, but when compared the neural activity by subtracting other condition from self condition, schizophrenia showed abnormal hypoactivity compared with healthy control, while SPD group showed enhanced neural activity when compared self with Sun Zhongshan. Taken together, the findings showed that schizophrenia patients exhibited defect behavioral performance and abnormal neural activity in the self-referential process.

Keyword自我 自我参照过程 精神分裂症谱系 功能磁共振成像
Document Type会议论文
Affiliation1.中国科学院心理研究所神经心理学与应用认知神经科学实验室, 中国科学院心理研究所心理健康重点试验室
First Author AffilicationInstitute of Psychology, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
杨晗雪,王玉娜,陈楚侨. 精神分裂症谱系的自我参照缺损研究[C],2018:1114-1115.
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