PSYCH OpenIR  > 中国科学院心理健康重点实验室
Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model
Sun, Lan1; Min, Li2; Li, Man3; Shao, Feng1; Wang, Weiwen4
第一作者Sun, Lan
2018-09-01
发表期刊BRAIN RESEARCH BULLETIN
通讯作者邮箱shaof@pku.edu.cn (f. shao) ; , wangww@psych.ac.cn (w. wang)
ISSN0361-9230
文章类型Article
卷号142页码:304-312
产权排序4
摘要

Complex interactions between genetic and environmental factors exert a sustained influence on the pathogenesis of schizophrenia (SCZ). Adolescent social isolation is regarded as a typical paradigm for SCZ. However, the underlying pathological mechanisms are not fully understood. In this study, adolescent Sprague-Dawley (SD) rats were placed in isolation rearing (IR) or social rearing (SR) conditions from postnatal day (PND) 21 to 34 to establish a SCZ disease model and a control model, respectively. Prepulse inhibition (PPI) assays and elevated plus maze tests were performed on PND 56. Next, prefrontal cortex (PFC) tissues were isolated for transcriptomic sequencing and RT-qPCR analyses. The results indicated that adolescent social isolation induced anxious behaviors and disrupted PPIs as well as specific PFC gene expression patterns in adult SD rats. A total of 196 genes were identified as upregulated, and 748 genes were identified as down-regulated in the IR group compared with those in the SR group. Differentially expressed genes (DEGs) were highly enriched in the KEGG pathways associated with the comorbidity of neurological disorder and oxidative phosphorylation (OXPHOS); 26 out of 27 comorbid neurological disorder-associated DEGs overlapped with 31 OXPHOS-associated DEGs. Those 26 overlapping DEGs were all upregulated in the IR group and could easily distinguish the IR group from the SR group; 6 of these DEGs (COX7C, NDUFB11, NDUFA2, NDUFC2, ATP5C1, and COX6A1) were verified by RT-qPCR. Here, we provide a systematic overview of gene expression alterations in adolescent-social-isolationinduced SCZ (ASI-SCZ), which suggests that genes that are associated with the comorbidity of neurological disorders, especially OXPHOS-related genes, contribute to the pathogenesis of ASI-SCZ.

关键词Schizophrenia Transcriptomic Analysis Adolescent Social Isolation Prefrontal Cortex (Pfc) Oxidative Phosphorylation (Oxphos) Comorbidity
DOI10.1016/j.brainresbull.2018.08.013
收录类别SCI
语种英语
资助项目Chinese Academy of Sciences[KJZD-EW-L04] ; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences ; National Natural Science Foundation of China[31470988] ; National Natural Science Foundation of China[81471122] ; Beijing Key Laboratory of Behavior and Mental Health
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000448223400034
出版者PERGAMON-ELSEVIER SCIENCE LTD
关键词[WOS]Prefrontal Cortex ; Adult Rats ; Latent Inhibition ; Serotonergic Function ; Receptor Expression ; Nucleus-accumbens ; Schizophrenia ; Gene ; Relevance ; Behavior
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27386
专题中国科学院心理健康重点实验室
通讯作者Shao, Feng; Wang, Weiwen
作者单位1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, Beijing 100871, Peoples R China
2.Capital Med Univ, Beijing Friendship Hosp, Dept Gastroenterol, Beijing 100050, Peoples R China
3.Tianjin Normal Univ, Sch Educ Sci, Dept Psychol, Tianjin 300387, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Sun, Lan,Min, Li,Li, Man,et al. Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model[J]. BRAIN RESEARCH BULLETIN,2018,142:304-312.
APA Sun, Lan,Min, Li,Li, Man,Shao, Feng,&Wang, Weiwen.(2018).Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model.BRAIN RESEARCH BULLETIN,142,304-312.
MLA Sun, Lan,et al."Transcriptomic analysis reveals oxidative phosphorylation activation in an adolescent social isolation rat model".BRAIN RESEARCH BULLETIN 142(2018):304-312.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Transcriptomic analy(1697KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Sun, Lan]的文章
[Min, Li]的文章
[Li, Man]的文章
百度学术
百度学术中相似的文章
[Sun, Lan]的文章
[Min, Li]的文章
[Li, Man]的文章
必应学术
必应学术中相似的文章
[Sun, Lan]的文章
[Min, Li]的文章
[Li, Man]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Transcriptomic analysis reveals oxidative phosphorylation activation in an adole.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。