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Neurocircuitry Mechanisms Involved in Habitual Drug Use and Transition of Behavioral Strategies
其他题名习惯化用药及其策略转换的神经环路调控机制
Zhang Meng1; Shen Fang2; Duan Ying2,3; Meng Yi-Ming2,3; Sui Nan2
第一作者Zhang Meng
2018-10-01
发表期刊PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
通讯作者邮箱suin@psych.ac.cn
ISSN1000-3282
文章类型Article
卷号45期号:10页码:1039-1046
产权排序2
摘要

The transition function impaired between goal-directed and habitual behavioral strategy are the main reasons of the formation of habitual drug-seeking behavior. Previous studies thought that the weakening ability of the prefrontal cortex to control the dorsomedial striatum, which is in charge of goal-directed system, mediated the habitual behavior. However, recent studies have found that the direct and indirect pathways of the dorsolateral striatum (DLS) can selectively regulate goal-directed and habitual systems. In addition, the projects from motor cortex to DLS can modulate the neurons' synaptic plasticity of dopamine D1 receptor (D1DR) and D2 receptor (D2DR) bidirectional, regulating the synergistic or antagonistic effects between direct and indirect pathways. Recent studies have also revealed that the amygdala, as a key brain area for regulating emotions, can mediate the functional connection between the nucleus accumbens and DLS in the habitual drug-seeking behavior through the functional transformation between the central amygdala and the basolateral amygdala. Moreover, there is a competitive relationship for the regulation of habitual drug-seeking behavior between D1DR and D2DR neurons in the striatum. In view of these, this paper will focus on the mechanism of abnormal brain functions, which are associated with the defects of the conversion in behavioral strategies accompanying with habitual drug use, in the cell-specific and the circuit-specific ways.

其他摘要

目标导向和习惯化行为策略转换缺陷是习惯化觅药行为形成的主要原因. 以往认为前额叶皮层对负责目标导向系统的背内侧纹状体控制能力的减弱介导了习惯化行为. 然而,最新研究发现,背外侧纹状体(DLS)的直接通路和间接通路可选择性调控目标导向和习惯化系统. 并且,运动皮层对DLS的投射可通过双向调节多巴胺D1受体(D1DR)和D2受体(D2DR)神经元突触可塑性,调控直接通路和间接通路间的协同或拮抗作用. 近期研究还发现,杏仁核作为调控情绪的关键脑区,可通过中央杏仁核与基底外侧杏仁核间的功能迁移从而介导习惯化觅药行为中伏隔核与DLS 间的功能连接. 此外,纹状体内D1DR 和D2DR 神经元对习惯化觅药行为的调控存在竞争关系. 鉴于此,本文将重点讨论伴随习惯化用药形成发生行为策略转换缺陷相关的细胞特异性和环路特异性的脑功能异常机制.

关键词Habitual Drug-seeking Transition Of Behavioral Strategies Neural Circuits Striatum Dopamine
DOI10.16476/j.pibb.2018.0119
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[31500893] ; National Basic Research Program[2015CB553501] ; National Natural Science Foundation[91332115] ; Institute of Psychology, Chinese Academy of Sciences[Y6CX221007]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000448490500004
出版者CHINESE ACAD SCIENCES, INST BIOPHYSICS
关键词[WOS]Cocaine-seeking Habits ; Dorsal Striatum ; Dorsolateral Striatum ; Basal Ganglia ; Addiction ; Dopamine ; Rats ; Acquisition ; Dependence ; Systems
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27392
专题中国科学院心理健康重点实验室
通讯作者Sui Nan
作者单位1.Guizhou Normal Univ, Sch Chem & Mat Sci, Guiyang 550000, Guizhou, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Zhang Meng,Shen Fang,Duan Ying,et al. Neurocircuitry Mechanisms Involved in Habitual Drug Use and Transition of Behavioral Strategies[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2018,45(10):1039-1046.
APA Zhang Meng,Shen Fang,Duan Ying,Meng Yi-Ming,&Sui Nan.(2018).Neurocircuitry Mechanisms Involved in Habitual Drug Use and Transition of Behavioral Strategies.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,45(10),1039-1046.
MLA Zhang Meng,et al."Neurocircuitry Mechanisms Involved in Habitual Drug Use and Transition of Behavioral Strategies".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 45.10(2018):1039-1046.
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