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Neurocircuitry Mechanisms Involved in Habitual Drug Use and Transition of Behavioral Strategies
Zhang Meng1; Shen Fang2; Duan Ying2,3; Meng Yi-Ming2,3; Sui Nan2
通讯作者Sui Nan(suin@psych.ac.cn)
2018-10-01
发表期刊PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
ISSN1000-3282
卷号45期号:10页码:1039-1046
摘要The transition function impaired between goal-directed and habitual behavioral strategy are the main reasons of the formation of habitual drug-seeking behavior. Previous studies thought that the weakening ability of the prefrontal cortex to control the dorsomedial striatum, which is in charge of goal-directed system, mediated the habitual behavior. However, recent studies have found that the direct and indirect pathways of the dorsolateral striatum (DLS) can selectively regulate goal-directed and habitual systems. In addition, the projects from motor cortex to DLS can modulate the neurons' synaptic plasticity of dopamine D1 receptor (D1DR) and D2 receptor (D2DR) bidirectional, regulating the synergistic or antagonistic effects between direct and indirect pathways. Recent studies have also revealed that the amygdala, as a key brain area for regulating emotions, can mediate the functional connection between the nucleus accumbens and DLS in the habitual drug-seeking behavior through the functional transformation between the central amygdala and the basolateral amygdala. Moreover, there is a competitive relationship for the regulation of habitual drug-seeking behavior between D1DR and D2DR neurons in the striatum. In view of these, this paper will focus on the mechanism of abnormal brain functions, which are associated with the defects of the conversion in behavioral strategies accompanying with habitual drug use, in the cell-specific and the circuit-specific ways.
关键词habitual drug-seeking transition of behavioral strategies neural circuits striatum dopamine
DOI10.16476/j.pibb.2018.0119
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China ; National Basic Research Program ; National Natural Science Foundation ; Institute of Psychology, Chinese Academy of Sciences
资助项目National Natural Science Foundation of China[31500893] ; National Basic Research Program[2015CB553501] ; National Natural Science Foundation[91332115] ; Institute of Psychology, Chinese Academy of Sciences[Y6CX221007]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000448490500004
出版者CHINESE ACAD SCIENCES, INST BIOPHYSICS
关键词[WOS]COCAINE-SEEKING HABITS ; DORSAL STRIATUM ; DORSOLATERAL STRIATUM ; BASAL GANGLIA ; ADDICTION ; DOPAMINE ; RATS ; ACQUISITION ; DEPENDENCE ; SYSTEMS
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27392
专题中国科学院心理健康重点实验室
通讯作者Sui Nan
作者单位1.Guizhou Normal Univ, Sch Chem & Mat Sci, Guiyang 550000, Guizhou, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
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GB/T 7714
Zhang Meng,Shen Fang,Duan Ying,et al. Neurocircuitry Mechanisms Involved in Habitual Drug Use and Transition of Behavioral Strategies[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2018,45(10):1039-1046.
APA Zhang Meng,Shen Fang,Duan Ying,Meng Yi-Ming,&Sui Nan.(2018).Neurocircuitry Mechanisms Involved in Habitual Drug Use and Transition of Behavioral Strategies.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,45(10),1039-1046.
MLA Zhang Meng,et al."Neurocircuitry Mechanisms Involved in Habitual Drug Use and Transition of Behavioral Strategies".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 45.10(2018):1039-1046.
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