Institutional Repository of Key Laboratory of Behavioral Science, CAS
Homotopic Connectivity in Early Pontine Infarction Predicts Late Motor Recovery | |
Shan, Yi1,2; Wang, Yin-Shan3,4; Zhang, Miao1,2; Rong, Dong-Dong1,2; Zhao, Zhi-Lian1,2; Cao, Yan-Xiang1,2; Wang, Pei-Pei1,2; Deng, Zheng-Zheng3,4; Ma, Qing-Feng5; Li, Kun-Cheng1,2; Zuo, Xi-Nian4; Lu, Jie1,2,6 | |
第一作者 | Shan, Yi |
通讯作者邮箱 | jie lu imaginglu@hotmail.com |
心理所单位排序 | 4 |
摘要 | Connectivity-based methods are essential to explore brain reorganization after a stroke and to provide meaningful predictors for late motor recovery. We aim to investigate the homotopic connectivity alterations during a 180-day follow-up of patients with pontine infarction to find an early biomarker for late motor recovery prediction. In our study, resting-state functional MRI was performed in 15 patients (11 males, 4 females, age: 57.87 +/- 6.50) with unilateral pontine infarction and impaired motor function during a period of 6 months (7, 14, 30, 90, and 180 days after stroke onset). Clinical neurological assessments were performed using the Fugl-Meyer scale (FM). 15 matched healthy volunteers were also recruited. Whole-brain functional homotopy in each individual scan was measured by voxel-mirrored homotopic connectivity (VMHC) values. Group-level analysiswas performed between stroke patients and normal controls. A Pearson correlation was performed to evaluate correlations between early VMHC and the subsequent 4 visits for behavioral measures during day 14 to day 180. We found in early stroke (within 7 days after onset), decreased VMHC was detected in the bilateral precentral and postcentral gyrus and precuneus/posterior cingulate cortex (PCC), while increased VMHC was found in the hippocampus/amygdala and frontal pole (P < 0.01). During follow-up, VMHC in the precentral and postcentral gyrus increased to the normal level from day 90, while VMHC in the precuneus/PCC presented decreased intensity during all time points (P < 0.05). The hippocampus/amygdala and frontal pole presented a higher level of VMHC during all time points (P < 0.05). Negative correlation was found between early VMHC in the hippocampus/amygdala with FM on day 14 (r = -0.59, p = 0.021), day 30 (r = -0.643, p = 0.01), day 90 (r = -0.693, p = 0.004), and day 180 (r = -0.668, p = 0.007). Furthermore, early VMHC in the frontal pole was negatively correlated with FM scores on day 30 (r = -0.662, p = 0.013), day 90 (r = -0.606, p = 0.017), and day 180 (r = -0.552, p = 0.033). Our study demonstrated the potential utility of early homotopic connectivity for prediction of late motor recovery in pontine infarction. |
关键词 | Pontine Infarction Homotopic Connectivity Functional Magnetic Resonance Imaging Motor Recovery Early Prediction |
2018-10-31 | |
语种 | 英语 |
DOI | 10.3389/fneur.2018.00907 |
发表期刊 | FRONTIERS IN NEUROLOGY |
ISSN | 1664-2295 |
卷号 | 9页码:10 |
期刊论文类型 | Article |
收录类别 | SCI |
资助项目 | Beijing Municipal Science and Tech Commission[Z171100000117012] ; Beijing Municipal Science and Tech Commission[Z161100002616023] ; Beijing Municipal Administration of Hospitals' Ascent Plan[DFL20180802] ; National Natural Science Foundation of China[81522021] ; National Natural Science Foundation of China[81522021] ; Beijing Municipal Administration of Hospitals' Ascent Plan[DFL20180802] ; Beijing Municipal Science and Tech Commission[Z161100002616023] ; Beijing Municipal Science and Tech Commission[Z171100000117012] |
出版者 | FRONTIERS MEDIA SA |
WOS关键词 | State Functional Connectivity ; Human Brain ; Stroke ; Networks ; Dysfunction ; Disorders ; Reorganization ; Poststroke ; Mechanisms ; Pathways |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Clinical Neurology ; Neurosciences |
WOS记录号 | WOS:000448904900002 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.psych.ac.cn/handle/311026/27407 |
专题 | 中国科学院行为科学重点实验室 |
通讯作者 | Lu, Jie |
作者单位 | 1.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China 2.Key Lab Magnet Resonance Imaging & Brain Informat, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Key Lab Behav Sci, Beijing, Peoples R China 5.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China 6.Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Shan, Yi,Wang, Yin-Shan,Zhang, Miao,et al. Homotopic Connectivity in Early Pontine Infarction Predicts Late Motor Recovery[J]. FRONTIERS IN NEUROLOGY,2018,9:10. |
APA | Shan, Yi.,Wang, Yin-Shan.,Zhang, Miao.,Rong, Dong-Dong.,Zhao, Zhi-Lian.,...&Lu, Jie.(2018).Homotopic Connectivity in Early Pontine Infarction Predicts Late Motor Recovery.FRONTIERS IN NEUROLOGY,9,10. |
MLA | Shan, Yi,et al."Homotopic Connectivity in Early Pontine Infarction Predicts Late Motor Recovery".FRONTIERS IN NEUROLOGY 9(2018):10. |
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