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Homotopic Connectivity in Early Pontine Infarction Predicts Late Motor Recovery
Shan, Yi1,2; Wang, Yin-Shan3,4; Zhang, Miao1,2; Rong, Dong-Dong1,2; Zhao, Zhi-Lian1,2; Cao, Yan-Xiang1,2; Wang, Pei-Pei1,2; Deng, Zheng-Zheng3,4; Ma, Qing-Feng5; Li, Kun-Cheng1,2; Zuo, Xi-Nian4; Lu, Jie1,2,6
First AuthorShan, Yi
Correspondent Emailjie lu
Contribution Rank4

Connectivity-based methods are essential to explore brain reorganization after a stroke and to provide meaningful predictors for late motor recovery. We aim to investigate the homotopic connectivity alterations during a 180-day follow-up of patients with pontine infarction to find an early biomarker for late motor recovery prediction. In our study, resting-state functional MRI was performed in 15 patients (11 males, 4 females, age: 57.87 +/- 6.50) with unilateral pontine infarction and impaired motor function during a period of 6 months (7, 14, 30, 90, and 180 days after stroke onset). Clinical neurological assessments were performed using the Fugl-Meyer scale (FM). 15 matched healthy volunteers were also recruited. Whole-brain functional homotopy in each individual scan was measured by voxel-mirrored homotopic connectivity (VMHC) values. Group-level analysiswas performed between stroke patients and normal controls. A Pearson correlation was performed to evaluate correlations between early VMHC and the subsequent 4 visits for behavioral measures during day 14 to day 180. We found in early stroke (within 7 days after onset), decreased VMHC was detected in the bilateral precentral and postcentral gyrus and precuneus/posterior cingulate cortex (PCC), while increased VMHC was found in the hippocampus/amygdala and frontal pole (P < 0.01). During follow-up, VMHC in the precentral and postcentral gyrus increased to the normal level from day 90, while VMHC in the precuneus/PCC presented decreased intensity during all time points (P < 0.05). The hippocampus/amygdala and frontal pole presented a higher level of VMHC during all time points (P < 0.05). Negative correlation was found between early VMHC in the hippocampus/amygdala with FM on day 14 (r = -0.59, p = 0.021), day 30 (r = -0.643, p = 0.01), day 90 (r = -0.693, p = 0.004), and day 180 (r = -0.668, p = 0.007). Furthermore, early VMHC in the frontal pole was negatively correlated with FM scores on day 30 (r = -0.662, p = 0.013), day 90 (r = -0.606, p = 0.017), and day 180 (r = -0.552, p = 0.033). Our study demonstrated the potential utility of early homotopic connectivity for prediction of late motor recovery in pontine infarction.

KeywordPontine Infarction Homotopic Connectivity Functional Magnetic Resonance Imaging Motor Recovery Early Prediction
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81522021] ; Beijing Municipal Administration of Hospitals' Ascent Plan[DFL20180802] ; Beijing Municipal Science and Tech Commission[Z161100002616023] ; Beijing Municipal Science and Tech Commission[Z171100000117012]
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000448904900002
WOS KeywordState Functional Connectivity ; Human Brain ; Stroke ; Networks ; Dysfunction ; Disorders ; Reorganization ; Poststroke ; Mechanisms ; Pathways
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Document Type期刊论文
Corresponding AuthorLu, Jie
Affiliation1.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
2.Key Lab Magnet Resonance Imaging & Brain Informat, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Key Lab Behav Sci, Beijing, Peoples R China
5.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
6.Capital Med Univ, Xuanwu Hosp, Dept Nucl Med, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Shan, Yi,Wang, Yin-Shan,Zhang, Miao,et al. Homotopic Connectivity in Early Pontine Infarction Predicts Late Motor Recovery[J]. FRONTIERS IN NEUROLOGY,2018,9:10.
APA Shan, Yi.,Wang, Yin-Shan.,Zhang, Miao.,Rong, Dong-Dong.,Zhao, Zhi-Lian.,...&Lu, Jie.(2018).Homotopic Connectivity in Early Pontine Infarction Predicts Late Motor Recovery.FRONTIERS IN NEUROLOGY,9,10.
MLA Shan, Yi,et al."Homotopic Connectivity in Early Pontine Infarction Predicts Late Motor Recovery".FRONTIERS IN NEUROLOGY 9(2018):10.
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