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Structural alterations in the caudate nucleus and precuneus in un-medicated anorexia nervosa patients
Yue Ling1; Wang Yi2; Kaye, Walter H.3; Kang Qing1; Huang Jia-bin1; Eric, Cheung F. C.4; Xiao Shi-fu1; Wang Zhen1; Chen Jue1; Raymond, Chan C. K.1,2,5,6
通讯作者Chen Jue(chenjue2088@163.com) ; Raymond, Chan C. K.(rckchan@psych.ac.cn)
2018-11-30
发表期刊PSYCHIATRY RESEARCH-NEUROIMAGING
ISSN0925-4927
卷号281页码:12-18
摘要Anorexia nervosa (AN) is a mental disorder characterized by a preoccupation with thinness and may be associated with brain structural alteration. The aim of the study was to examine the brain structural alteration in AN patients, including subcortical structure volume and cortical thickness. Thirty-five un-medicated AN patients and 20 matched healthy controls underwent structural magnetic resonance imaging brain scans. High resolution structural images were acquired on a SIEMENS 3T scanner and preprocessed using FreeSurfer software. Subcortical structure volume and cortical thickness were compared between the two groups. We found larger percentage of caudate volume relative to total grey matter (GM) volume in the AN group. Reduced cortical thickness at the left precuneus was also observed in AN patients. Moreover, an interaction between group and hemisphere was found, suggesting that cortical thinning was more prominent in the left hemisphere in AN patients. These findings provide further evidence for structural brain abnormalities in patients with AN.
关键词Anorexia nervosa Structural magnetic resonance imaging Caudate nucleus Precuneus
DOI10.1016/j.pscychresns.2018.08.009
收录类别SCI
语种英语
项目资助者Foundation of Shanghai Municipal Commission of Health and Family Planning ; National Natural Science Foundation of China ; Key Characteristic Specialist Department of Shanghai Mental Health Centre ; advanced overseas research team training project in the fourth round of three-year action project of public health in Shanghai ; Shanghai Mental Health Center Special Discipline of Psychosomatic Medicine ; Natural Science Foundation of Shanghai ; Shanghai Association for Science and Technology ; Science Foundation of Shanghai Mental Health Centre ; Beijing Training Project for the Leading Talents in S T ; China Scholarship Council
资助项目Foundation of Shanghai Municipal Commission of Health and Family Planning[20124105] ; Foundation of Shanghai Municipal Commission of Health and Family Planning[20144Y0081] ; National Natural Science Foundation of China[31400884] ; National Natural Science Foundation of China[81201055] ; National Natural Science Foundation of China[81771461] ; Key Characteristic Specialist Department of Shanghai Mental Health Centre[2013-YJTSZK-02] ; advanced overseas research team training project in the fourth round of three-year action project of public health in Shanghai[GWTD2015509] ; Shanghai Mental Health Center Special Discipline of Psychosomatic Medicine[2017-TSXK-01] ; Natural Science Foundation of Shanghai[16ZR1430400] ; Shanghai Association for Science and Technology[16411965200] ; Science Foundation of Shanghai Mental Health Centre[SMHCRSD01] ; Beijing Training Project for the Leading Talents in S T[Z151100000315020] ; China Scholarship Council
WOS研究方向Neurosciences & Neurology ; Psychiatry
WOS类目Clinical Neurology ; Neuroimaging ; Psychiatry
WOS记录号WOS:000448020100002
出版者ELSEVIER IRELAND LTD
关键词[WOS]HUMAN CEREBRAL-CORTEX ; EATING ATTITUDES TEST ; CORTICAL THICKNESS ; MORPHOLOGICAL-CHANGES ; WEIGHT RESTORATION ; BULIMIA-NERVOSA ; BRAIN ; VOLUMES ; ADOLESCENT ; WOMEN
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文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27479
专题中国科学院心理健康重点实验室
通讯作者Chen Jue; Raymond, Chan C. K.
作者单位1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai Clin Ctr Mental Disorders,Dept Clin Psyc, Shanghai, Peoples R China
2.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
3.Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
4.Castle Peak Hosp, Dept Adult Psychiat, Hong Kong, Hong Kong, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
6.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Translat Neuropsychol & Appl Cognit Neurosci Lab, Shanghai, Peoples R China
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Yue Ling,Wang Yi,Kaye, Walter H.,et al. Structural alterations in the caudate nucleus and precuneus in un-medicated anorexia nervosa patients[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2018,281:12-18.
APA Yue Ling.,Wang Yi.,Kaye, Walter H..,Kang Qing.,Huang Jia-bin.,...&Raymond, Chan C. K..(2018).Structural alterations in the caudate nucleus and precuneus in un-medicated anorexia nervosa patients.PSYCHIATRY RESEARCH-NEUROIMAGING,281,12-18.
MLA Yue Ling,et al."Structural alterations in the caudate nucleus and precuneus in un-medicated anorexia nervosa patients".PSYCHIATRY RESEARCH-NEUROIMAGING 281(2018):12-18.
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