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Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study
Fan, Lu1,2; Sun, Ya-Bin1,2; Sun, Ze-Kun1,2; Wang, Ning1,2; Luo, Fei1,2; Yu, Feng3; Wang, Jin-Yan1,2
First AuthorFan, Lu
2018-10-23
Source PublicationSCIENTIFIC REPORTS
Correspondent Emailyufeng.yf@163.com ; wangjy@psych.ac.cn
ISSN2045-2322
SubtypeArticle
Volume8Pages:13
Contribution Rank1
Abstract

Pain, especially chronic pain, can lead to cognitive deficits. Mismatch negativity (MMN) is a change-specific component of the auditory event-related brain potential (ERP) that is thought to provide a unique window into sensory memory processes. The present study was designed to determine how chronic and acute pain affects auditory sensory memory. In experiment 1, MMNs elicited by standard and deviant auditory stimuli at short and long inter-stimulus intervals (ISIs) were compared between trigeminal neuralgia (TN) patients and demographically matched healthy controls (HCs). The TN patients were found to have stronger attenuation of the MMN at longer ISIs than HCs. Correlation analysis revealed a significant positive correlation between the sensory subscale of McGill Pain Questionnaire and MMN amplitude reduction across ISI conditions. In experiment 2, MMNs recorded before, during, and after the cold pressor test were compared in healthy subjects. MMN amplitude was significantly reduced during pain exposure and recovered immediately thereafter. These results suggest that both chronic pain and acute pain can interfere with automatic change detection processes in the brain. This study provides the first evidence that chronic pain patients have a faster auditory memory trace decay than HCs.

DOI10.1038/s41598-018-34099-y
Indexed BySCI
Language英语
Funding ProjectCAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016K02] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH 2014G01] ; NNSF[31671140] ; NNSF[31471061] ; NNSF[31171067] ; NNSF (National Natural Science Foundation of China)[31271092] ; NNSF (National Natural Science Foundation of China)[31271092] ; NNSF[31171067] ; NNSF[31471061] ; NNSF[31671140] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH 2014G01] ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2016K02]
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000448050500021
PublisherNATURE PUBLISHING GROUP
WOS KeywordAnterior Cingulate Cortex ; Anxiety Stress Scales ; Psychometric Properties ; Selective-attention ; Basic Research ; Back-pain ; Stimulus ; Intensity ; Responses ; Brain
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27488
Collection中国科学院心理健康重点实验室
Corresponding AuthorWang, Jin-Yan
Affiliation1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
3.Chinese PLA Gen Hosp Jinan Mil Command, Dept Neurosurg, Jinan 250031, Shandong, Peoples R China
Recommended Citation
GB/T 7714
Fan, Lu,Sun, Ya-Bin,Sun, Ze-Kun,et al. Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study[J]. SCIENTIFIC REPORTS,2018,8:13.
APA Fan, Lu.,Sun, Ya-Bin.,Sun, Ze-Kun.,Wang, Ning.,Luo, Fei.,...&Wang, Jin-Yan.(2018).Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study.SCIENTIFIC REPORTS,8,13.
MLA Fan, Lu,et al."Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study".SCIENTIFIC REPORTS 8(2018):13.
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