Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital

doi:10.1007/s00213-018-5009-2

PSYCH OpenIR

	Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital
	Cao, Zeyuan 1; Wu, Shuang 2,3; Wang, Chao 2,3; Wang, Li 4; Soares, Jair C.5; He, Shu-Chang 2,3; Zhang, Xiang Yang 4,5
通讯作者	He, Shu-Chang(shuchangh@pku.edu.cn) ; Zhang, Xiang Yang(zhangxy@psych.ac.cn)
摘要	Objective Many studies have reported that long-term exposure to job-related stress can lead to burnout, which may be influenced by genetic and environmental factors. Burnout correlates with depression. This study investigated whether one tag polymorphism rs6354 in 5-HTT gene modulated the influence of job-related stress on burnout in the medical professionals in a Chinese Han population, which to our best knowledge has not been explored. Methods Seven hundred twelve subjects were recruited from a general hospital and measured for burnout symptoms using the Maslach Burnout Inventory (MBI), the stress using the House and Rizzo's Work Stress Scale, and the stressors using the Evers, Frese, and Cooper's Sources of Pressure Scale. The 5-HTT rs6354 polymorphism was genotyped in 376 subjects. Results The majority of correlations between the work stress score or the six stressor scores and three burnout subscores were significant (all p < 0.05). There was no significant main effect of the 5-HTT rs6354 genotype on burnout symptoms; however, there was a statistically significant interaction between 5-HTT rs6354 and work stress on burnout (F = 5.08, df = 2, 369, p = 0.007). In the low stress group, G allele carriers had significantly higher burnout level than TT homozygote (F = 11.60, df = 1, 48, p < 0.001). On the contrary, in the high stress group, G allele carriers exhibited significantly lower burnout level compared to TT homozygote (F = 3.86, df = 1, 103, p = 0.025). Conclusions Our findings suggest that the 5-HTT rs6354 polymorphism may modulate the influence of job-related stress on burnout by adjusting serotonin transporter function and neurotransmission, showing that individuals with TT genotype displayed a greater susceptibility to both the detrimental effects of higher stress and the beneficial effects of lower stress compared to those with G allele, which supports the differential-susceptibility hypothesis.
关键词	Burnout Stress Serotonin transporter Genotype Association Interaction
	2018-11-01
语种	英语
DOI	10.1007/s00213-018-5009-2
发表期刊	PSYCHOPHARMACOLOGY
ISSN	0033-3158
卷号	235 期号:11 页码:3125-3135
收录类别	SCI
资助项目	National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81271491] ; National Natural Science Foundation of China[81271491] ; National Natural Science Foundation of China[81571322] ; National Natural Science Foundation of China[81371477]
出版者	SPRINGER
WOS关键词	SINGLE-NUCLEOTIDE POLYMORPHISMS ; LIFE EVENTS ; DEPRESSIVE SYMPTOMS ; ASSOCIATION ; REGION ; SUSCEPTIBILITY ; MODERATION ; SLC6A4 ; REPLICATION ; DISORDERS
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目	Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号	WOS:000448485500005
资助机构	National Natural Science Foundation of China
引用统计
文献类型	期刊论文
条目标识符	http://ir.psych.ac.cn/handle/311026/27489
通讯作者	He, Shu-Chang; Zhang, Xiang Yang
作者单位	1.Brandeis Univ, Dept Biochem, Waltham, MA 02254 USA 2.Peking Univ, Sch Psychol & Cognit Sci, Beijing 100871, Peoples R China 3.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Beijing 100871, Peoples R China 4.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China 5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA
推荐引用方式 GB/T 7714	Cao, Zeyuan,Wu, Shuang,Wang, Chao,et al. Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital[J]. PSYCHOPHARMACOLOGY,2018,235(11):3125-3135.
APA	Cao, Zeyuan.,Wu, Shuang.,Wang, Chao.,Wang, Li.,Soares, Jair C..,...&Zhang, Xiang Yang.(2018).Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital.PSYCHOPHARMACOLOGY,235(11),3125-3135.
MLA	Cao, Zeyuan,et al."Serotonin transporter gene (5-HTT) rs6354 polymorphism, job-related stress, and their interaction in burnout in healthcare workers in a Chinese hospital".PSYCHOPHARMACOLOGY 235.11(2018):3125-3135.