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Prefrontal cortex dysfunction during verbal fluency task after atypicalantipsychotic treatment in schizophrenia: A near-infrared Chock for spectroscopy imaging study
Luo, Xiaoyu1,2; Qi, Yu1; Wang, Hesheng1; Wang, Yijun1; He, Tingyu1; Rong, Bei1; Liu, Zhongchun1; Zhou, Yuan6,7; Wang, Gaohua1,4,5; Wang, Huiling1,3
第一作者Luo, Xiaoyu
2018-11-01
发表期刊NEUROSCIENCE LETTERS
通讯作者邮箱hlwang@whu.edu.cn (h. wang)
ISSN0304-3940
文章类型Article
卷号686页码:101-105
产权排序6
摘要

A number of near-infrared spectroscopy (NIRS) studies in schizophrenia have shown that there is a significant dysfunction of the prefrontal cortex (PFC) in patients with schizophrenia, but it remains unclear how atypical antipsychotics affect the function of the PFC. To investigate the changes in brain activation patterns in schizophrenia who accepted antipsychotic treatment, we used NIRS to measure the hemodynamic changes of the PFC in patients with schizophrenia at the time of enrollment and after 4 weeks of treatment during a verbal fluency task (VFT). We included 16 schizophrenia and 17 sex- and age- matched healthy controls. Compared with the healthy controls, the VFT performance was significantly worse in patients with schizophrenia, as was the activation of the PFC. Furthermore, after 4 weeks of treatment, there was no significant improvement in VFT performance and the activation of the PFC in schizophrenia. Our results suggest that the function of the PFC and cognitive skills in schizophrenia were significantly impaired and do not improve from a short-term treatment of atypical antipsychotics.

关键词Schizophrenia Prefrontal Cortex (Pfc) Atypical Antipsychotics Verbal Fluency Task (Vft) Near-infrared Spectroscopy (Nirs)
DOI10.1016/j.neulet.2018.09.001
收录类别SCI
语种英语
资助项目National Science and Technologic Program of China[2015BAI13B02] ; National Natural Science Foundation of China[91132301] ; Natural Science Foundation of Hubei Province[014CFB732]
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000449897900016
出版者ELSEVIER IRELAND LTD
关键词[WOS]Major Depressive Disorder ; 1st-episode Schizophrenia ; Drug-naive ; Association ; Activation ; Improvement ; Impairment ; Symptoms
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27554
专题中国科学院行为科学重点实验室
通讯作者Wang, Huiling
作者单位1.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Hubei, Peoples R China
2.Wuhan Wuchang Hosp, Dept Psychiat, Wuhan 430000, Hubei, Peoples R China
3.Hubei Prov Key Lab Developmentally Originated Dis, Wuhan 430071, Hubei, Peoples R China
4.Hubei Inst Neurol & Psychiat Res, Wuhan 430060, Hubei, Peoples R China
5.Hubei Univ Sci & Technol, Xianning 437100, Peoples R China
6.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China
7.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
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GB/T 7714
Luo, Xiaoyu,Qi, Yu,Wang, Hesheng,et al. Prefrontal cortex dysfunction during verbal fluency task after atypicalantipsychotic treatment in schizophrenia: A near-infrared Chock for spectroscopy imaging study[J]. NEUROSCIENCE LETTERS,2018,686:101-105.
APA Luo, Xiaoyu.,Qi, Yu.,Wang, Hesheng.,Wang, Yijun.,He, Tingyu.,...&Wang, Huiling.(2018).Prefrontal cortex dysfunction during verbal fluency task after atypicalantipsychotic treatment in schizophrenia: A near-infrared Chock for spectroscopy imaging study.NEUROSCIENCE LETTERS,686,101-105.
MLA Luo, Xiaoyu,et al."Prefrontal cortex dysfunction during verbal fluency task after atypicalantipsychotic treatment in schizophrenia: A near-infrared Chock for spectroscopy imaging study".NEUROSCIENCE LETTERS 686(2018):101-105.
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