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Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals
Ibrahim, Omar1; Sutherland, Heidi G.1; Avgan, Nesli1; Spriggens, Lauren K.2,3; Lea, Rod A.1; Haupt, Larisa M.1; Shum, David H. K.2,3,4; Griffiths, Lyn R.1
Corresponding AuthorGriffiths, Lyn R.(lyn.griffiths@qut.edu.au)
2018-11-01
Source PublicationNEUROBIOLOGY OF LEARNING AND MEMORY
ISSN1074-7427
Volume155Pages:330-336
AbstractThe common polymorphism rs17518584, near the cell adhesion molecule 2 gene (CADM2), was previously identified as playing a role in information processing speed in a genome-wide association study of executive functions and processing speed performed in a cohort of non-demented older adults. In this study, we investigated this polymorphism in a younger population cohort 30 years old, median age 19 years), with no known memory or psychiatric disorders, for which we had phenotyped all participants for memory function (n = 514), and a subset of the participants for executive functions (n = 338), using a battery of tests measuring visuo-spatial memory, working memory, verbal memory, and frontal lobe functions (visual scanning, graphomotor speed, and cognitive flexibility). The polymorphism rs17518584 was genotyped by a restriction fragment length polymorphism assay and analysis indicated that the CADM2 polymorphism showed evidence of association with information processing speed as inferred from scores from the Stroop Word, Colour, and Colour Word Tests (p = 0.005, p = 0.04, and p = 0.028, respectively, in a dominant inheritance model), as well as Trail Making Test Part A (p = 0.005 in an additive model). Significant associations of rs17518584 with scores from other tests of memory subtypes were not detected. The findings of this study provide further support for a role of CADM2 in aspects of cognitive function, in particular reading and information processing speed, and suggest that this role extends to younger individuals.
KeywordMemory Executive functions Information processing speed Genetic polymorphisms Adhesion molecule Neural plasticity CADM2 Stroop test Trail Making Test
DOI10.1016/j.nlm.2018.08.001
Indexed BySCI
Language英语
Funding OrganizationAustralian Research Council grant The Genetic Basis of Human Memory ; Australian Government EIF Super Science Funds, Therapeutic Innovation Australia - Queensland Node project
Funding ProjectAustralian Government EIF Super Science Funds, Therapeutic Innovation Australia - Queensland Node project ; Australian Research Council grant The Genetic Basis of Human Memory[DP130101921] ; Australian Research Council grant The Genetic Basis of Human Memory[DP130101921] ; Australian Government EIF Super Science Funds, Therapeutic Innovation Australia - Queensland Node project
WOS Research AreaBehavioral Sciences ; Neurosciences & Neurology ; Psychology
WOS SubjectBehavioral Sciences ; Neurosciences ; Psychology ; Psychology, Multidisciplinary
WOS IDWOS:000449310000035
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
WOS KeywordGENOME-WIDE ASSOCIATION ; ANTERIOR CINGULATE CORTEX ; WORKING-MEMORY ; PROCESSING SPEED ; GENETIC OVERLAP ; NORMATIVE DATA ; STROOP TEST ; SCHIZOPHRENIA ; METAANALYSIS ; ADHESION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27560
Collection中国科学院心理健康重点实验室
Corresponding AuthorGriffiths, Lyn R.
Affiliation1.QUT, Sch Biomed Sci, Inst Hlth & Biomed Innovat, Genom Res Ctr, Brisbane, Qld, Australia
2.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia
3.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia
4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Ibrahim, Omar,Sutherland, Heidi G.,Avgan, Nesli,et al. Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals[J]. NEUROBIOLOGY OF LEARNING AND MEMORY,2018,155:330-336.
APA Ibrahim, Omar.,Sutherland, Heidi G..,Avgan, Nesli.,Spriggens, Lauren K..,Lea, Rod A..,...&Griffiths, Lyn R..(2018).Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals.NEUROBIOLOGY OF LEARNING AND MEMORY,155,330-336.
MLA Ibrahim, Omar,et al."Investigation of the CADM2 polymorphism rs17518584 in memory and executive functions measures in a cohort of young healthy individuals".NEUROBIOLOGY OF LEARNING AND MEMORY 155(2018):330-336.
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