中国科学院心理研究所机构知识库

###################################

　Objective　To investigate the interacting effect of deviant peer affiliation and rs4680 polymorphism of catechol-O-methyl-transferase（COMT） gene on adolescent behavioral problems.Methods　Data of 780 adolescents aged from 11 to 17 years were drawn from Beijing Twin Registry from January 2011 to December 2012.Achenbach Youth Self Report and Deviant Peer Affiliation Questionnaire were used for assessing behavioral problems and deviant peer affiliation，respectively. Saliva samples were collected and genome DNA was extracted for genotyping the COMT rs4680 polymorphism.Multiple linear regression analysis was used to detect factors influencing scores of adolescent problem behaviors.Results　Average scores of behavioral problems for AA group，AG group and GG group of rs4680 in COMT gene were（13.5±9.1），（13.0±10.7） and （12.3±10.8），respectively.Difference between the three groups was not significant（F=0.55，P=0.577）.Multiple linear regression model revealed there was statistical significance in the interacting effect of age，deviant peer affiliation，deviant peer affiliation and COMT gene on behavioral problems 〔β=0.90，95%CI（0.47，1.18），P<0.001；β=1.08，95%CI（0.98，1.44），P<0.001；β=0.44，95%CI（0.08，0.75），P=0.014〕.Further analysis found that GG group was more vulnerable to deviant peer affiliation，and more behavioral problems were developed when exposing to negative peer environments.Conclusion 　Adolescent behavioral problems are affected by both genetic factors and environmental factors.Adolescents with certain genetic propensity are more vulnerable to negative peer environments.