Alternative TitleInteracting Effect of Deviant Peer Affiliation and COMT rs4680 Polymorphism on Adolescent Behavioral Problems
张净雯1,2; 李新影1,2
First Author张净雯
Source Publication中国全科医学
Contribution Rank1


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 Objective To investigate the interacting effect of deviant peer affiliation and rs4680 polymorphism of catechol-O-methyl-transferase(COMT) gene on adolescent behavioral problems.Methods Data of 780 adolescents aged from 11 to 17 years were drawn from Beijing Twin Registry from January 2011 to December 2012.Achenbach Youth Self Report and Deviant Peer Affiliation Questionnaire were used for assessing behavioral problems and deviant peer affiliation,respectively. Saliva samples were collected and genome DNA was extracted for genotyping the COMT rs4680 polymorphism.Multiple linear regression analysis was used to detect factors influencing scores of adolescent problem behaviors.Results Average scores of behavioral problems for AA group,AG group and GG group of rs4680 in COMT gene were(13.5±9.1),(13.0±10.7) and (12.3±10.8),respectively.Difference between the three groups was not significant(F=0.55,P=0.577).Multiple linear regression model revealed there was statistical significance in the interacting effect of age,deviant peer affiliation,deviant peer affiliation and COMT gene on behavioral problems 〔β=0.90,95%CI(0.47,1.18),P<0.001;β=1.08,95%CI(0.98,1.44),P<0.001;β=0.44,95%CI(0.08,0.75),P=0.014〕.Further analysis found that GG group was more vulnerable to deviant peer affiliation,and more behavioral problems were developed when exposing to negative peer environments.Conclusion  Adolescent behavioral problems are affected by both genetic factors and environmental factors.Adolescents with certain genetic propensity are more vulnerable to negative peer environments.

Keyword问题行为 儿茶酚胺氧位甲基转移酶基因 交互分析
Indexed ByCSCD
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Document Type期刊论文
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
张净雯,李新影. 不良同伴交往与儿茶酚胺氧位甲基转移酶基因的交互作用对青少年问题行为的影响研究[J]. 中国全科医学,2018:4.
APA 张净雯,&李新影.(2018).不良同伴交往与儿茶酚胺氧位甲基转移酶基因的交互作用对青少年问题行为的影响研究.中国全科医学,4.
MLA 张净雯,et al."不良同伴交往与儿茶酚胺氧位甲基转移酶基因的交互作用对青少年问题行为的影响研究".中国全科医学 (2018):4.
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