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Alternative TitleNeurocircuitry Mechanisms Involved in Habitual Drug Useand Transition of Behavioral Strategies
张萌1; 沈芳2; 段颖2,3; 蒙怡铭2,3; 隋南2
First Author张萌
Contribution Rank2


Other Abstract

The transition function impaired between goal-directed and habitual behavioral strategy are the main reasons of the formation of habitual drug-seeking behavior. Previous studies thought that the weakening ability of the prefrontal cortex to control the dorsomedial striatum, which is in charge of goal-directed system, mediated the habitual behavior. However, recent studies have found that the direct and indirect pathways of the dorsolateral striatum (DLS) can selectively regulate goal-directed and habitual systems. In addition, the projects from motor cortex to DLS can modulate the neurons’ synaptic plasticity of dopamine D1 receptor (D1DR) and D2 receptor (D2DR) bidirectional, regulating the synergistic or antagonistic effects between direct and indirect pathways. Recent studies have also revealed that the amygdala, as a key brain area for regulating emotions, can mediate the functional connection between the nucleus accumbens and DLS in the habitual drug-seeking behavior through the functional transformation between the central amygdala and the basolateral amygdala. Moreover, there is a competitive relationship for the regulation of habitual drug-seeking behavior between D1DR and D2DR neurons in the striatum. In view of these, this paper will focus on the mechanism of abnormal brain functions, which are associated with the defects of the conversion in behavioral strategies accompanying with habitual drug use, in the cell-specific and the circuit-specific ways.

Keyword习惯化觅药 行为策略转换 神经环路 纹状体 多巴胺
Source Publication生物化学与生物物理进展
Indexed ByCSCD
Citation statistics
Document Type期刊论文
Corresponding Author隋南
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
张萌,沈芳,段颖,等. 习惯化用药及其策略转换的神经环路调控机制[J]. 生物化学与生物物理进展,2018,45(10):1039-1046.
APA 张萌,沈芳,段颖,蒙怡铭,&隋南.(2018).习惯化用药及其策略转换的神经环路调控机制.生物化学与生物物理进展,45(10),1039-1046.
MLA 张萌,et al."习惯化用药及其策略转换的神经环路调控机制".生物化学与生物物理进展 45.10(2018):1039-1046.
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