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Alternative TitleThe modulatory effects of depression on pain perception:A review of animal model studies
王宁1,2; 魏潇1,2; 王锦琰1,2; 罗非1,2
First Author王宁
Source Publication科学通报
Contribution Rank1


Other Abstract

Depression is a complicated affective disorder and the most common cause of disability. Globally, more than 350 million people suffer from depression at present. The patients with depression may have a set of the mental symptoms, including depressed mood, anhedonia and anergia. They may also express irritability, disrupted sleep and/or appetite, poor concentration and even suicidal tendency. Depression is highly comorbid with pain. Studies have proved that nearly 65% patients with depression also suffer from pain, and elevated pain perception has been found in depressed patients. Both depression and chronic pain are incurable diseases. The concurrence of depression and pain not only causes great suffering to the patients, but also brings a heavy medical burden to the society. However, laboratory studies have found bidirectional modulation of depression on pain. Some researchers observed that experimentally-induced negative mood increased self-reported pain in chronic back pain patients, while others reported that subjects with depressive disorders displayed elevated threshold and tolerance when exposed to thermal- and electrical-evoked pain. The intricate relationship between pain and depression has been concerned for many years. Animal models are useful tools to investigate the neuronal mechanisms of the depression and pain comorbidity. As were in human subjects, experiments in animals also yielded contradictory results. Some studies proved enhanced pain perception in depressive-like animals, but some others found that depression could reduce the sensitivity to pain stimulation. There are many kinds of depression models, such as chronic restraint stress, chronic social stress, unpredictable chronic mild stress, olfactory bulbectomy, Wistar-Kyoto rat, and reserpine-induced monoamine depletion. The difference of these models may contribute to the divergent effects of depression on pain. Since 2010, our laboratory has conducted a series studies about the comorbidity of depression and pain. Using animal models of unpredictable chronic mild stress and olfactory bulbectomy, our previous work demonstrated that depression could enhance the persistent inflammatory pain response but reduce the noxious stimulus-evoked withdrawal behavior in rats. These results supported that another important factor of the divergent effects may be the pain modality. Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Researchers have described three dimensions of pain: sensory-discrimination, affective-motivation and cognitive-evaluation. The effects of depression on different pain modalities may be associated with different processing patterns of these three dimensions. In this review, we will discuss the interaction between depression and pain modalities in some animal models. We hope that this review could provide guidance for the future researches about the comorbidities of depression and pain.

Keyword抑郁 疼痛 动物实验
Project Intro.

国家自然科学基金(31271092,31671140,31500857,31171067,31471061);; 中国科学院心理健康院重点实验室项目(KLMH2016K02,KLMH2014G01)资助

Citation statistics
Document Type期刊论文
Corresponding Author罗非
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
王宁,魏潇,王锦琰,等. 抑郁症对疼痛感知的调节作用:动物实验研究[J]. 科学通报,2018,63(20):1984-1997.
APA 王宁,魏潇,王锦琰,&罗非.(2018).抑郁症对疼痛感知的调节作用:动物实验研究.科学通报,63(20),1984-1997.
MLA 王宁,et al."抑郁症对疼痛感知的调节作用:动物实验研究".科学通报 63.20(2018):1984-1997.
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