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Altered structural-functional coupling of large-scale brain networks in early Tourette syndrome children
Wen, Hongwei1,2,3; Liu, Yue5; Zhang, Jishui6; Peng, Yun5; He, Huiguang1,2,4
First AuthorWen, Hongwei
2018
Conference NameMedical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging
Correspondent Emailhuiguang.he@ia.ac.cn
Source PublicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10578
Conference DateFebruary 11, 2018 - February 13, 2018
Conference PlaceHouston, TX
CountryUnited states
Author of SourceDECTRIS Ltd. ; The Society of Photo-Optical Instrumentation Engineers (SPIE)
PublisherSPIE
Contribution Rank4
Abstract

Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder and its pathophysiological mechanism remains elusive. At present, TS-related abnormalities in either structural connectivity (SC) or functional connectivity (FC) have extensively been described, and discrepancies were apparent between the SC and FC studies. However, abnormalities in the SC-FC correlation for early TS children remain poorly understood. In our study, we used probabilistic diffusion tractography and resting-state FC to construct large-scale structural and functional brain networks for 34 drug-naive TS children and 42 healthy children. Graph theoretical approaches were employed to divide the group-averaged FC networks into functional modules. The Pearson correlation between the entries of SC and FC were estimated as SC-FC coupling within whole-brain and each module. Although five common functional modules (including the sensorimotor, default-mode, fronto-parietal, temporo-occipital and subcortical modules) were identified in both groups, we found SC-FC coupling in TS exhibited increased at the whole-brain and functional modular level, especially within sensorimotor and subcortical modules. The increased SC-FC coupling may suggest that TS pathology leads to functional interactions that are more directly related to the underlying SC of the brain and may be indicative of more stringent and less dynamic brain function in TS children. Together, our study demonstrated that altered whole-brain and module-dependent SC-FC couplings may underlie abnormal brain function in TS, and highlighted the potential for using multimodal neuroimaging biomarkers for TS diagnosis as well as understanding the pathophysiologic mechanisms of TS. © 2018 SPIE.

KeywordTourette Syndrome Probabilistic Diffusion Tractography Structural Connectivity Resting-state Functional Connectivity Graph Theoretical Analysis Modularity Sc-fc Coupling
Subject AreaMolecular Imaging
DOI10.1117/12.2283231
ISBN16057422
Indexed ByEI
Language英语
EI KeywordsCorrelation Methods - Diagnosis - Graph Theory - Medical Applications - Neuroimaging
Citation statistics
Document Type会议论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27749
Collection脑与认知科学国家重点实验室
Corresponding AuthorHe, Huiguang
Affiliation1.Research Center for Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing; 100190, China;
2.University of Chinese Academy of Sciences, Beijing, China;
3.Department of Psychology, Southwest University, Chongqing, China;
4.Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China;
5.Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing; 100045, China;
6.Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing, China
Recommended Citation
GB/T 7714
Wen, Hongwei,Liu, Yue,Zhang, Jishui,et al. Altered structural-functional coupling of large-scale brain networks in early Tourette syndrome children[C]//DECTRIS Ltd., The Society of Photo-Optical Instrumentation Engineers (SPIE):SPIE,2018.
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