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Altered structural-functional coupling of large-scale brain networks in early Tourette syndrome children
Wen, Hongwei1,2,3; Liu, Yue5; Zhang, Jishui6; Peng, Yun5; He, Huiguang1,2,4
第一作者Wen, Hongwei
2018
会议名称Medical Imaging 2018: Biomedical Applications in Molecular, Structural, and Functional Imaging
通讯作者邮箱huiguang.he@ia.ac.cn
会议录名称Progress in Biomedical Optics and Imaging - Proceedings of SPIE
卷号10578
会议日期February 11, 2018 - February 13, 2018
会议地点Houston, TX
会议举办国United states
会议录编者/会议主办者DECTRIS Ltd. ; The Society of Photo-Optical Instrumentation Engineers (SPIE)
出版者SPIE
产权排序4
摘要

Tourette syndrome (TS) is a childhood-onset neurobehavioral disorder and its pathophysiological mechanism remains elusive. At present, TS-related abnormalities in either structural connectivity (SC) or functional connectivity (FC) have extensively been described, and discrepancies were apparent between the SC and FC studies. However, abnormalities in the SC-FC correlation for early TS children remain poorly understood. In our study, we used probabilistic diffusion tractography and resting-state FC to construct large-scale structural and functional brain networks for 34 drug-naive TS children and 42 healthy children. Graph theoretical approaches were employed to divide the group-averaged FC networks into functional modules. The Pearson correlation between the entries of SC and FC were estimated as SC-FC coupling within whole-brain and each module. Although five common functional modules (including the sensorimotor, default-mode, fronto-parietal, temporo-occipital and subcortical modules) were identified in both groups, we found SC-FC coupling in TS exhibited increased at the whole-brain and functional modular level, especially within sensorimotor and subcortical modules. The increased SC-FC coupling may suggest that TS pathology leads to functional interactions that are more directly related to the underlying SC of the brain and may be indicative of more stringent and less dynamic brain function in TS children. Together, our study demonstrated that altered whole-brain and module-dependent SC-FC couplings may underlie abnormal brain function in TS, and highlighted the potential for using multimodal neuroimaging biomarkers for TS diagnosis as well as understanding the pathophysiologic mechanisms of TS. © 2018 SPIE.

关键词Tourette Syndrome Probabilistic Diffusion Tractography Structural Connectivity Resting-state Functional Connectivity Graph Theoretical Analysis Modularity Sc-fc Coupling
学科领域Molecular Imaging
DOI10.1117/12.2283231
ISBN号16057422
收录类别EI
语种英语
EI主题词Correlation Methods - Diagnosis - Graph Theory - Medical Applications - Neuroimaging
引用统计
文献类型会议论文
条目标识符http://ir.psych.ac.cn/handle/311026/27749
专题脑与认知科学国家重点实验室
通讯作者He, Huiguang
作者单位1.Research Center for Brain-inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, Beijing; 100190, China;
2.University of Chinese Academy of Sciences, Beijing, China;
3.Department of Psychology, Southwest University, Chongqing, China;
4.Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Beijing, China;
5.Department of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing; 100045, China;
6.Department of Neurology, Beijing Children's Hospital, Capital Medical University, Beijing, China
推荐引用方式
GB/T 7714
Wen, Hongwei,Liu, Yue,Zhang, Jishui,et al. Altered structural-functional coupling of large-scale brain networks in early Tourette syndrome children[C]//DECTRIS Ltd., The Society of Photo-Optical Instrumentation Engineers (SPIE):SPIE,2018.
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