PSYCH OpenIR  > 中国科学院心理健康重点实验室
Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats
Alizamini, Mirmohammadali Mirramezani1,2,3; Kavianpour, Mohadeseh1; Karimi-Haghighi, Saeideh1; Fatahi, Zahra1; Haghparast, Abbas1
Corresponding AuthorHaghparast, Abbas(Haghparast@sbmu.ac.ir)
2018-12-01
Source PublicationPEPTIDES
ISSN0196-9781
Volume110Pages:40-46
AbstractIt has been shown that the hippocampus plays an essential role in the regulation of reward and memory as indicated by the conditioned place preference (CPP) paradigm. Morphine-induced CPP is a common method to consider motivational properties of morphine in animals. Recently, this model has been used in many laboratories to investigate neuronal mechanisms underlying reinstatement of morphine seeking induced by drug reexposure. Our previous studies indicate that the hippocampus especially CA1 region is involved in reinstatement of drug-seeking behaviors. Also, several studies have shown that orexin attenuates key functional and behavioral effects of its co-transmitter dynorphin. The present study evaluates the role of orexinergic receptors within the CA1 region of the hippocampus in the reinstatement of morphine-induced CPP. Therefore, after the extinction period, the different doses (SB 334867; 0.3, 3, and 30 nM/0.5 mu l DMSO) of either orexin-1 or -2 receptor antagonists were bilaterally microinjected into the CA1, 15 min before receiving an effective priming dose of morphine (1 mg/kg). The results revealed that administration of both SB 334867 and TCS OX2 29 prior to injection of the priming dose of morphine significantly reduced the reinstatement of morphine-induced CPP without altering the animal's locomotor activity. Also, the 50% effective dose value of SB 334867 on the reinstatement of morphine seeking behavior was close three times more than that in TCS OX2 29 treatment group. Therefore, the consequences suggested that both orexin receptors in the CA1 play a considerable role in the reinstatement of morphine-induced CPP.
KeywordReward Orexin CA1 region of the hippocampus Reinstatement Conditioned place preference Rat
DOI10.1016/j.peptides.2018.10.011
Indexed BySCI
Language英语
Funding OrganizationNeuroscience Research Center ; Shahid Beheshti University of Medical Sciences, Tehran, Iran
Funding ProjectShahid Beheshti University of Medical Sciences, Tehran, Iran ; Neuroscience Research Center[96-459-A] ; Neuroscience Research Center[96-459-A] ; Shahid Beheshti University of Medical Sciences, Tehran, Iran
WOS Research AreaBiochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy
WOS IDWOS:000451996300006
PublisherELSEVIER SCIENCE INC
WOS KeywordPRIMING-INDUCED REINSTATEMENT ; CONDITIONED PLACE PREFERENCE ; D2-LIKE DOPAMINE-RECEPTORS ; VENTRAL TEGMENTAL AREA ; CA1 REGION ; NUCLEUS-ACCUMBENS ; DENTATE GYRUS ; HIPPOCAMPUS ; ACQUISITION ; EXPRESSION
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Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27814
Collection中国科学院心理健康重点实验室
Corresponding AuthorHaghparast, Abbas
Affiliation1.Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Sch Med, POB 19615-1178, Tehran, Iran
2.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Alizamini, Mirmohammadali Mirramezani,Kavianpour, Mohadeseh,Karimi-Haghighi, Saeideh,et al. Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats[J]. PEPTIDES,2018,110:40-46.
APA Alizamini, Mirmohammadali Mirramezani,Kavianpour, Mohadeseh,Karimi-Haghighi, Saeideh,Fatahi, Zahra,&Haghparast, Abbas.(2018).Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats.PEPTIDES,110,40-46.
MLA Alizamini, Mirmohammadali Mirramezani,et al."Intra-hippocampal administration of orexin receptor antagonists dose-dependently attenuates reinstatement of morphine seeking behavior in extinguished rats".PEPTIDES 110(2018):40-46.
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