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Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients
An, Huimei1; Du, Xiangdong2; Huang, Xingbing3; Qi, Lingyan1; Jia, Qiufang2; Yin, Guangzhong2; Xiao, Chunling1; Huang, Xu-Feng4; Ning, Yuping3; Cassidy, Ryan M.5; Wang, Li6; Soares, Jair C.5; Zhang, Xiang Yang5,6
First AuthorAn, Huimei
2018-11-29
Source PublicationTRANSLATIONAL PSYCHIATRY
Correspondent Emailzhangxy@psych.ac.cn
ISSN2158-3188
SubtypeArticle
Volume8Pages:7
Contribution Rank6
Abstract

Antipsychotic pharmacotherapy is strongly obesogenic and is associated with increased oxidative stress in patients with schizophrenia. However, whether these changes reflect psychopathology, antipsychotic efficacy, or some other factor is not known. Our study aims to investigate the degree of oxidative stress in different BMI categories and to identify clinical symptomatology that may be paired with increased oxidative stress in a schizophrenia population. To this end, we performed a cross-sectional study and recruited 89 long-term inpatients with schizophrenia and collected the following variables: plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), routine biochemical analysis, and psychopathology through the Positive and Negative Syndrome Scale (PANSS). The results indicate that the levels of the lipid peroxidation product, MDA, were significantly higher in the high BMI group than the low (normal) BMI group. As expected, high BMI was associated with an atherogenic lipid profile; however, it was also associated with fewer psychopathological symptoms. Multiple regression analysis found that MDA levels, the PANSS general psychopathology subscore, and triglyceride levels (all p < 0.05) were independent contributors to the BMI in patients. These results suggested that oxidative stress may play an important role in antipsychotic-induced weight gain. Further investigations using the longitudinal design in first-episode schizophrenia patients are needed to explore the beneficial effect of antioxidants on the abnormal lipid metabolism mediated by antipsychotic treatment.

DOI10.1038/s41398-018-0303-7
Indexed BySCI
Language英语
Funding ProjectSuzhou Key Lab for Biological Psychiatry[SZS201722] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Beijing Science and Technology Foundation[Z151100004015080] ; Beijing Municipal Excellent Talents Foundation[2014000021469G218] ; Beijing Natural Science Foundation[7182074] ; National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81371477] ; Beijing Natural Science Foundation[7182074] ; Beijing Municipal Excellent Talents Foundation[2014000021469G218] ; Beijing Science and Technology Foundation[Z151100004015080] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Key Lab for Biological Psychiatry[SZS201722]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000452318200001
PublisherNATURE PUBLISHING GROUP
WOS KeywordTotal Antioxidant Capacity ; Weight-gain ; Superoxide-dismutase ; Lipid-peroxidation ; Antipsychotic-drugs ; Ginkgo-biloba ; Risk-factors ; Olanzapine ; Haloperidol ; Clozapine
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27823
Collection健康与遗传心理学研究室
Corresponding AuthorZhang, Xiang Yang
Affiliation1.Peking Univ, Beijing Hui Long Guan Hosp, Beijing, Peoples R China
2.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Jiangsu, Peoples R China
3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China
4.Univ Wollongong, Illawarra Hlth & Med Res Inst, Sch Med, Wollongong, NSW 2522, Australia
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
6.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
An, Huimei,Du, Xiangdong,Huang, Xingbing,et al. Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients[J]. TRANSLATIONAL PSYCHIATRY,2018,8:7.
APA An, Huimei.,Du, Xiangdong.,Huang, Xingbing.,Qi, Lingyan.,Jia, Qiufang.,...&Zhang, Xiang Yang.(2018).Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients.TRANSLATIONAL PSYCHIATRY,8,7.
MLA An, Huimei,et al."Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients".TRANSLATIONAL PSYCHIATRY 8(2018):7.
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