PSYCH OpenIR  > 健康与遗传心理学研究室
Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients
An, Huimei1; Du, Xiangdong2; Huang, Xingbing3; Qi, Lingyan1; Jia, Qiufang2; Yin, Guangzhong2; Xiao, Chunling1; Huang, Xu-Feng4; Ning, Yuping3; Cassidy, Ryan M.5; Wang, Li6; Soares, Jair C.5; Zhang, Xiang Yang5,6
第一作者An, Huimei
2018-11-29
发表期刊TRANSLATIONAL PSYCHIATRY
通讯作者邮箱zhangxy@psych.ac.cn
ISSN2158-3188
文章类型Article
卷号8页码:7
产权排序6
摘要

Antipsychotic pharmacotherapy is strongly obesogenic and is associated with increased oxidative stress in patients with schizophrenia. However, whether these changes reflect psychopathology, antipsychotic efficacy, or some other factor is not known. Our study aims to investigate the degree of oxidative stress in different BMI categories and to identify clinical symptomatology that may be paired with increased oxidative stress in a schizophrenia population. To this end, we performed a cross-sectional study and recruited 89 long-term inpatients with schizophrenia and collected the following variables: plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), routine biochemical analysis, and psychopathology through the Positive and Negative Syndrome Scale (PANSS). The results indicate that the levels of the lipid peroxidation product, MDA, were significantly higher in the high BMI group than the low (normal) BMI group. As expected, high BMI was associated with an atherogenic lipid profile; however, it was also associated with fewer psychopathological symptoms. Multiple regression analysis found that MDA levels, the PANSS general psychopathology subscore, and triglyceride levels (all p < 0.05) were independent contributors to the BMI in patients. These results suggested that oxidative stress may play an important role in antipsychotic-induced weight gain. Further investigations using the longitudinal design in first-episode schizophrenia patients are needed to explore the beneficial effect of antioxidants on the abnormal lipid metabolism mediated by antipsychotic treatment.

DOI10.1038/s41398-018-0303-7
收录类别SCI
语种英语
资助项目National Natural Science Foundation of China[81371477] ; Beijing Natural Science Foundation[7182074] ; Beijing Municipal Excellent Talents Foundation[2014000021469G218] ; Beijing Science and Technology Foundation[Z151100004015080] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Key Lab for Biological Psychiatry[SZS201722]
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000452318200001
出版者NATURE PUBLISHING GROUP
关键词[WOS]Total Antioxidant Capacity ; Weight-gain ; Superoxide-dismutase ; Lipid-peroxidation ; Antipsychotic-drugs ; Ginkgo-biloba ; Risk-factors ; Olanzapine ; Haloperidol ; Clozapine
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27823
专题健康与遗传心理学研究室
通讯作者Zhang, Xiang Yang
作者单位1.Peking Univ, Beijing Hui Long Guan Hosp, Beijing, Peoples R China
2.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Jiangsu, Peoples R China
3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China
4.Univ Wollongong, Illawarra Hlth & Med Res Inst, Sch Med, Wollongong, NSW 2522, Australia
5.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
6.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
An, Huimei,Du, Xiangdong,Huang, Xingbing,et al. Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients[J]. TRANSLATIONAL PSYCHIATRY,2018,8:7.
APA An, Huimei.,Du, Xiangdong.,Huang, Xingbing.,Qi, Lingyan.,Jia, Qiufang.,...&Zhang, Xiang Yang.(2018).Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients.TRANSLATIONAL PSYCHIATRY,8,7.
MLA An, Huimei,et al."Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients".TRANSLATIONAL PSYCHIATRY 8(2018):7.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Obesity, altered oxi(414KB)期刊论文出版稿限制开放CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[An, Huimei]的文章
[Du, Xiangdong]的文章
[Huang, Xingbing]的文章
百度学术
百度学术中相似的文章
[An, Huimei]的文章
[Du, Xiangdong]的文章
[Huang, Xingbing]的文章
必应学术
必应学术中相似的文章
[An, Huimei]的文章
[Du, Xiangdong]的文章
[Huang, Xingbing]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。