PSYCH OpenIR  > 中国科学院心理健康重点实验室
Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors
Zhang, Xiaoyu1,2; Zhang, Jianxin1; Wang, Li1; Zhang, Wencai1
First AuthorZhang, Xiaoyu
2018-11-30
Source PublicationFRONTIERS IN PSYCHIATRY
Correspondent Emailzhangwc@psych.ac.cn
ISSN1664-0640
SubtypeArticle
Volume9Pages:9
Contribution Rank1
Abstract

Objective: To detect the changes of gray matter volume (GMV) and their correlation with severity of symptom in patients with post-traumatic stress disorder (PTSD) who were defined with updated DSM-5 diagnostic criteria. Method: 71 participants were assigned into PTSD group (n = 35) or trauma-exposed control (TEC) group (n = 36) with the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Voxel-based morphometry analysis was used to detect alterations in GMV in the PTSD group. Results: We found that the PTSD group had larger GMV in the left middle temporal gyrus (MTG) and in the right dorsal medial prefrontal cortex (dmPFC), and smaller GMV in the region of the right temporal pole (TP) than the TEC group. We also found that PTSD Checklist for DSM-5 (PCL-5) scores correlated positively with the left MTG and right dmPFC GMV, and negatively with left TP GMV. These correlations were consistent with the findings of the between-group comparisons. Conclusions: GMV alterations in the MTG, dmPFC, and TP are detected in the group comparisons and correlated with symptom severity when classifying PTSD individuals according to DSM-5 diagnostic criteria within an earthquake-exposed population.

KeywordPtsd Dsm-5 Gray Matter Volume Temporal Lobe Earthquake Survivors
DOI10.3389/fpsyt.2018.00629
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[31371131] ; National Natural Science Foundation of China[31100746] ; Key Research Program of the Chinese Academy of Sciences[KJZD-EW-L04] ; National Key Technology Research and Development Program of China[2013BAI08B02] ; National Key Technology Research and Development Program of China[2013BAI08B02] ; Key Research Program of the Chinese Academy of Sciences[KJZD-EW-L04] ; National Natural Science Foundation of China[31100746] ; National Natural Science Foundation of China[31371131]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000451911400001
PublisherFRONTIERS MEDIA SA
WOS KeywordPosttraumatic-stress-disorder ; Voxel-based Morphometry ; Dsm-iv-tr ; Prefrontal Cortex ; Functional Connectivity ; Anterior Cingulate ; Neural Activation ; Maltreated Youth ; Amygdala Volume ; Anxiety
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27829
Collection中国科学院心理健康重点实验室
Corresponding AuthorZhang, Wencai
Affiliation1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,et al. Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors[J]. FRONTIERS IN PSYCHIATRY,2018,9:9.
APA Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,&Zhang, Wencai.(2018).Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors.FRONTIERS IN PSYCHIATRY,9,9.
MLA Zhang, Xiaoyu,et al."Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors".FRONTIERS IN PSYCHIATRY 9(2018):9.
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