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Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors
Zhang, Xiaoyu1,2; Zhang, Jianxin1; Wang, Li1; Zhang, Wencai1
通讯作者Zhang, Wencai(zhangwc@psych.ac.cn)
2018-11-30
发表期刊FRONTIERS IN PSYCHIATRY
ISSN1664-0640
卷号9页码:9
摘要Objective: To detect the changes of gray matter volume (GMV) and their correlation with severity of symptom in patients with post-traumatic stress disorder (PTSD) who were defined with updated DSM-5 diagnostic criteria. Method: 71 participants were assigned into PTSD group (n = 35) or trauma-exposed control (TEC) group (n = 36) with the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Voxel-based morphometry analysis was used to detect alterations in GMV in the PTSD group. Results: We found that the PTSD group had larger GMV in the left middle temporal gyrus (MTG) and in the right dorsal medial prefrontal cortex (dmPFC), and smaller GMV in the region of the right temporal pole (TP) than the TEC group. We also found that PTSD Checklist for DSM-5 (PCL-5) scores correlated positively with the left MTG and right dmPFC GMV, and negatively with left TP GMV. These correlations were consistent with the findings of the between-group comparisons. Conclusions: GMV alterations in the MTG, dmPFC, and TP are detected in the group comparisons and correlated with symptom severity when classifying PTSD individuals according to DSM-5 diagnostic criteria within an earthquake-exposed population.
关键词PTSD DSM-5 gray matter volume temporal lobe earthquake survivors
DOI10.3389/fpsyt.2018.00629
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China ; National Key Technology Research and Development Program of China ; Key Research Program of the Chinese Academy of Sciences
资助项目National Natural Science Foundation of China[31100746] ; National Natural Science Foundation of China[31371131] ; National Key Technology Research and Development Program of China[2013BAI08B02] ; Key Research Program of the Chinese Academy of Sciences[KJZD-EW-L04]
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000451911400001
出版者FRONTIERS MEDIA SA
关键词[WOS]POSTTRAUMATIC-STRESS-DISORDER ; VOXEL-BASED MORPHOMETRY ; DSM-IV-TR ; PREFRONTAL CORTEX ; FUNCTIONAL CONNECTIVITY ; ANTERIOR CINGULATE ; NEURAL ACTIVATION ; MALTREATED YOUTH ; AMYGDALA VOLUME ; ANXIETY
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27829
专题中国科学院心理健康重点实验室
通讯作者Zhang, Wencai
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
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GB/T 7714
Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,et al. Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors[J]. FRONTIERS IN PSYCHIATRY,2018,9:9.
APA Zhang, Xiaoyu,Zhang, Jianxin,Wang, Li,&Zhang, Wencai.(2018).Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors.FRONTIERS IN PSYCHIATRY,9,9.
MLA Zhang, Xiaoyu,et al."Altered Gray Matter Volume and Its Correlation With PTSD Severity in Chinese Earthquake Survivors".FRONTIERS IN PSYCHIATRY 9(2018):9.
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