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Brain Mechanisms Underlying Visuo-Orthographic Deficits in Children With Developmental Dyslexia
Cao, Fan1,2,3; Yan, Xin2; Spray, Gregory J.2; Liu, Yanni4; Deng, Yuan5
通讯作者Cao, Fan(caofan3@mail.sysu.edu.cn)
2018-12-06
发表期刊FRONTIERS IN HUMAN NEUROSCIENCE
ISSN1662-5161
卷号12页码:13
摘要Multiple hypotheses have been proposed to explain the reading difficulty caused by developmental dyslexia (DD). The current study examined visuo-orthographic processing in children with dyslexia to determine whether orthographic deficits are explainable based solely on visual deficits. To identify orthographic-specific, visual perception-specific, and overlapping deficits, we included two tasks (lexical and perceptual) in three Chinese subject groups: children with DD, age-matched controls (AC), and reading matched controls (RC) using functional magnetic resonance imaging (fMRI). We found that the left precuneus showed decreased activation across both tasks for the DD group compared to the two control groups, thus reflecting visual processing deficits in children with DD, which also affects orthographic processing. Furthermore, we found that the functional connectivity between left middle occipital gyrus (LMOG) and left inferior frontal gyrus (IFG) was decreased in the DD group compared to AC and RC for only the lexical task. This suggests a weaker association between orthography and phonology for children with DD. In addition, the children with DD showed decreased functional connectivity between the LMOG and right parahippocampal gyrus for only the visual perceptual task, thereby indicating a weaker association between visual regions for DD during visual symbol processing. Taken together, our findings suggest that the observed orthographic processing deficit in DD might be driven by both a basic visual deficit, and a linguistic deficit.
关键词dyslexia fMRI orthographic deficit visual deficit PPI
DOI10.3389/fnhum.2018.00490
收录类别SCI
语种英语
项目资助者Fundamental Research Funds for the Central Universities ; Chinese University of Hong Kong, Shenzhen
资助项目Fundamental Research Funds for the Central Universities ; Chinese University of Hong Kong, Shenzhen
WOS研究方向Neurosciences & Neurology ; Psychology
WOS类目Neurosciences ; Psychology
WOS记录号WOS:000452301300001
出版者FRONTIERS MEDIA SA
关键词[WOS]READING DIFFICULTIES ; CONNECTIVITY ; ACTIVATION ; ATTENTION ; RESPONSES ; TASK ; PET ; REPRESENTATION ; ORGANIZATION ; RECOGNITION
引用统计
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27835
专题认知与发展心理学研究室
通讯作者Cao, Fan
作者单位1.Sun Yat Sen Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China
2.Michigan State Univ, Dept Commun Sci & Disorders, E Lansing, MI 48824 USA
3.Chinese Univ Hong Kong, Sch Humanities & Social Sci, Shenzhen, Shenzhen, Peoples R China
4.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
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Cao, Fan,Yan, Xin,Spray, Gregory J.,et al. Brain Mechanisms Underlying Visuo-Orthographic Deficits in Children With Developmental Dyslexia[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2018,12:13.
APA Cao, Fan,Yan, Xin,Spray, Gregory J.,Liu, Yanni,&Deng, Yuan.(2018).Brain Mechanisms Underlying Visuo-Orthographic Deficits in Children With Developmental Dyslexia.FRONTIERS IN HUMAN NEUROSCIENCE,12,13.
MLA Cao, Fan,et al."Brain Mechanisms Underlying Visuo-Orthographic Deficits in Children With Developmental Dyslexia".FRONTIERS IN HUMAN NEUROSCIENCE 12(2018):13.
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