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Brain Mechanisms Underlying Visuo-Orthographic Deficits in Children With Developmental Dyslexia
Cao, Fan1,2,3; Yan, Xin2; Spray, Gregory J.2; Liu, Yanni4; Deng, Yuan5
First AuthorCao, Fan
2018-12-06
Source PublicationFRONTIERS IN HUMAN NEUROSCIENCE
Correspondent Emailcaofan3@mail.sysu.edu.cn; caofan@cuhk.edu.cn
ISSN1662-5161
SubtypeArticle
Volume12Pages:13
Contribution Rank5
Abstract

Multiple hypotheses have been proposed to explain the reading difficulty caused by developmental dyslexia (DD). The current study examined visuo-orthographic processing in children with dyslexia to determine whether orthographic deficits are explainable based solely on visual deficits. To identify orthographic-specific, visual perception-specific, and overlapping deficits, we included two tasks (lexical and perceptual) in three Chinese subject groups: children with DD, age-matched controls (AC), and reading matched controls (RC) using functional magnetic resonance imaging (fMRI). We found that the left precuneus showed decreased activation across both tasks for the DD group compared to the two control groups, thus reflecting visual processing deficits in children with DD, which also affects orthographic processing. Furthermore, we found that the functional connectivity between left middle occipital gyrus (LMOG) and left inferior frontal gyrus (IFG) was decreased in the DD group compared to AC and RC for only the lexical task. This suggests a weaker association between orthography and phonology for children with DD. In addition, the children with DD showed decreased functional connectivity between the LMOG and right parahippocampal gyrus for only the visual perceptual task, thereby indicating a weaker association between visual regions for DD during visual symbol processing. Taken together, our findings suggest that the observed orthographic processing deficit in DD might be driven by both a basic visual deficit, and a linguistic deficit.

KeywordDyslexia Fmri Orthographic Deficit Visual Deficit Ppi
DOI10.3389/fnhum.2018.00490
Indexed BySCI
Language英语
Funding ProjectChinese University of Hong Kong, Shenzhen ; Fundamental Research Funds for the Central Universities ; Fundamental Research Funds for the Central Universities ; Chinese University of Hong Kong, Shenzhen
WOS Research AreaNeurosciences & Neurology ; Psychology
WOS SubjectNeurosciences ; Psychology
WOS IDWOS:000452301300001
PublisherFRONTIERS MEDIA SA
WOS KeywordReading Difficulties ; Connectivity ; Activation ; Attention ; Responses ; Task ; Pet ; Representation ; Organization ; Recognition
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27835
Collection认知与发展心理学研究室
Corresponding AuthorCao, Fan
Affiliation1.Sun Yat Sen Univ, Dept Psychol, Guangzhou, Guangdong, Peoples R China
2.Michigan State Univ, Dept Commun Sci & Disorders, E Lansing, MI 48824 USA
3.Chinese Univ Hong Kong, Sch Humanities & Social Sci, Shenzhen, Shenzhen, Peoples R China
4.Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA
5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Cao, Fan,Yan, Xin,Spray, Gregory J.,et al. Brain Mechanisms Underlying Visuo-Orthographic Deficits in Children With Developmental Dyslexia[J]. FRONTIERS IN HUMAN NEUROSCIENCE,2018,12:13.
APA Cao, Fan,Yan, Xin,Spray, Gregory J.,Liu, Yanni,&Deng, Yuan.(2018).Brain Mechanisms Underlying Visuo-Orthographic Deficits in Children With Developmental Dyslexia.FRONTIERS IN HUMAN NEUROSCIENCE,12,13.
MLA Cao, Fan,et al."Brain Mechanisms Underlying Visuo-Orthographic Deficits in Children With Developmental Dyslexia".FRONTIERS IN HUMAN NEUROSCIENCE 12(2018):13.
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