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Revisiting the persistent negative symptoms proxy score using the Clinical Assessment Interview for Negative Symptoms
Li, Ying1,2,3,6; Li, Wen-xiu3; Zou, Ying-min1,2,6; Yang, Zhuo-ya1,2,6; Xie, Dong-jie1,2,6; Yang, Yin1,6; Lu, Simon S. Y.1,4,6; Strauss, Gregory P.5; Cheung, Eric F. C.4; Chan, Raymond C. K.1,2,6
First AuthorLi, Ying
2018-12-01
Source PublicationSCHIZOPHRENIA RESEARCH
Correspondent Emailrckchan@psych.ac.cn
ISSN0920-9964
SubtypeArticle
Volume202Pages:248-253
Contribution Rank1
Abstract

Objective: The present study aimed to validate a severity cut-off of negative symptoms for persistent negative symptoms (PNS) identification using the Clinical Assessment Interview for Negative Symptoms (CAINS). Method: A total of 206 patients with schizophrenia were recruited and divided into the PNS group (n = 57) and the Non-PNS group (n = 149) using PNS criteria based on the SANS and the SAPS. To determine the appropriate cut-offs on the CAINS in identifying PNS, Receiver Operating Characteristic (ROC) curve analysis was conducted in the PNS and Non-PNS groups. Results: Our results showed that the cutoffs for identifying PNS on the CAINS total score, the Motivation and Pleasure (MAP) subscale score and the Expression (EXP) subscale score were 25, 17, and 5 respectively. Area Under the Curve (AUC) analysis indicated excellent discrimination of the PNS group from the Non-PNS group using the cut-off for the CAINS total score. However, discrimination was somewhat better for the MAP subscale score than the EXP subscale score. The Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of the MAP subscale were 81.54% and 97.16%. Conclusion: We found that the cut-off scores derived from the CAINS to identify PNS are comparable to existing scales. The CAINS offers an alternative means in identifying PNS patients in clinical trials that overcomes methodological and conceptual limitations of older scales. (C) 2018 Elsevier B.V. All rights reserved.

KeywordCains Persistent Negative Symptoms Schizophrenia Roc Curve
DOI10.1016/j.schres.2018.07.005
Indexed BySCI
Language英语
Funding ProjectNational Science Fund China[81571317] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science and Technology Commission Grant[Z161100000216138]
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000452298400037
PublisherELSEVIER SCIENCE BV
WOS Keyword1st Episode Schizophrenia ; Scale ; Validation ; Version ; Depression ; Apathy
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27870
Collection中国科学院心理健康重点实验室
Corresponding AuthorChan, Raymond C. K.
Affiliation1.Inst Psychol, Neuropsychot & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
3.Haidian Dist Mental Hlth Prevent Treatment Hosp, Beijing, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Univ Georgia, Dept Psychol, Athens, GA 30602 USA
6.Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Li, Ying,Li, Wen-xiu,Zou, Ying-min,et al. Revisiting the persistent negative symptoms proxy score using the Clinical Assessment Interview for Negative Symptoms[J]. SCHIZOPHRENIA RESEARCH,2018,202:248-253.
APA Li, Ying.,Li, Wen-xiu.,Zou, Ying-min.,Yang, Zhuo-ya.,Xie, Dong-jie.,...&Chan, Raymond C. K..(2018).Revisiting the persistent negative symptoms proxy score using the Clinical Assessment Interview for Negative Symptoms.SCHIZOPHRENIA RESEARCH,202,248-253.
MLA Li, Ying,et al."Revisiting the persistent negative symptoms proxy score using the Clinical Assessment Interview for Negative Symptoms".SCHIZOPHRENIA RESEARCH 202(2018):248-253.
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