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An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support
Li, Man1,2,3,4; Xu, Hang4,5; Wang, Weiwen4,5
First AuthorLi, Man
2018-12-11
Source PublicationFRONTIERS IN PSYCHIATRY
Correspondent Emailwangww@psych.ac.cn
ISSN1664-0640
SubtypeArticle
Volume9Pages:8
Contribution Rank4
Abstract

Social stress is a prevalent etiological environmental factor that can affect health, especially during adolescence. Either experiencing or witnessing a traumatic event during adolescence can increase the risk of psychiatric disorders, such as PTSD. The present study attempted to establish an improved social stress model to better distinguish the effects of physical and emotional social stress on the behavior and physiology of adolescent mice. In addition, we investigated how social support affected these stress-induced changes in social behavior. On PND 28, male littermates were exposed to either physical stress (PS) or emotional stress (ES), afterwards, half of them were paired-housed and the others were singly housed. The PS exposed mice were directly confronted with a violent aggressor using the social defeat stress (SDS) paradigm for 15 min/trial (with the total of 10 trials randomly administered over a week), while the ES exposed mice were placed in a neighboring compartment to witness the PS procedure. Our results indicate that both stressors induced an effective stress response in adolescent mice, but PS and ES had differential influence in the context of relevant social anxiety/fear and social interaction with peers. Additionally, social support following stress exposure exerted beneficial effects on the social anxiety/fear in ES exposed mice, but not on PS exposed mice, suggesting that the type of stressor may affect the intervention efficacy of social support. These findings provide extensive evidence that physical and emotional stressors induce different effects. Moreover, ES exposed mice, rather than PS exposed mice, seemed to bene fit from social support. In summary, the study suggests that this paradigm will be helpful in investigating the effects of psychological intervention for the treatment of stress-related psychiatric disorders.

KeywordAdolescent Physical Stress Emotional Stress Social Behavior Social Support
DOI10.3389/fpsyt.2018.00688
Indexed BySCI
Language英语
Funding ProjectCAS Key Laboratory of Mental Health, Institute of Psychology ; Chinese Academy of Sciences[KJZD-EW-L04] ; National Natural Science Foundation of China[31470988] ; National Natural Science Foundation of China[81471122] ; Beijing Key Laboratory of Behavior and Mental Health ; Philosophy and Social Sciences Planning Foundation of Tianjin[TJJXQN17-003] ; Tianjin Normal university[043-135202WW1713] ; Department of Psychology
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000452843100001
PublisherFRONTIERS MEDIA SA
WOS KeywordWitnessing Traumatic Events ; Stress ; Brain ; Adulthood ; Anxiety ; Bdnf ; Impairments ; Expression ; Depression ; Preference
Citation statistics
Document Type期刊论文
Identifierhttp://ir.psych.ac.cn/handle/311026/27933
Collection中国科学院心理研究所
Corresponding AuthorWang, Weiwen
Affiliation1.Tianjin Normal Univ, Dept Psychol, Tianjin, Peoples R China
2.Tianjin Normal Univ, Acad Psychol & Behav, Tianjin, Peoples R China
3.Ctr Collaborat Innovat Assessment & Promot Mental, Tianjin, Peoples R China
4.Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
First Author AffilicationKey Laboratory of Mental Health, CAS
Corresponding Author AffilicationKey Laboratory of Mental Health, CAS
Recommended Citation
GB/T 7714
Li, Man,Xu, Hang,Wang, Weiwen. An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support[J]. FRONTIERS IN PSYCHIATRY,2018,9:8.
APA Li, Man,Xu, Hang,&Wang, Weiwen.(2018).An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support.FRONTIERS IN PSYCHIATRY,9,8.
MLA Li, Man,et al."An Improved Model of Physical and Emotional Social Defeat: Different Effects on Social Behavior and Body Weight of Adolescent Mice by Interaction With Social Support".FRONTIERS IN PSYCHIATRY 9(2018):8.
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