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Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia
Zhang, Xiang Yang1,2; Du, Xiangdong3; Yin, Guangzhong3; Zhang, Yingyang3; Chen, Dachun4; Xiu, Meihong4; Wang, Changhong5; Zhang, Ruilong5; Cassidy, Ryan M.2; Ning, Yuping6; Huang, Xingbing6; Soares, Jair C.2
通讯作者Zhang, Xiang Yang(xiang.y.zhang@uth.tmc.edu)
摘要Background: It is well established that patients with chronic schizophrenia have a substantially higher rate of attempted and completed suicide than the general population. However, the actual prevalence of suicide attempts at first-episode psychosis is relatively unknown. Previous studies showed that suicidal schizophrenia patients demonstrate higher cognitive function than nonsuicidal patients, though with inconsistent results. The aims of the study were to examine the prevalence of suicide attempts and the association of this prevalence with demographic and clinical variables and cognitive function in Chinese first-episode, drug-naive (FEDN) schizophrenia patients using a cross-sectional and case-control design. Method: A total of 357 FEDN inpatients meeting DSM-IV criteria for schizophrenia and 380 healthy controls were enrolled and completed a detailed in-house questionnaire. The suicide attempt data were collected from medical records and interviews with the patients and their family members. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was administered to measure cognition in the 28 patients with and 95 patients without a history of suicide attempt and 151 healthy controls. Also, patients were rated on the Positive and Negative Syndrome Scale (PANSS). This study was conducted from June 2013 to December 2015. Results: A suicide attempt rate of 12.0% was found in inpatients with first-episode schizophrenia. The attempters were more likely to smoke (34.4% vs 17.9%; chi(2) = 5.49, P =.019) and had lower severity of negative symptoms (F-1,F-354 = 4.12, P =.043) as compared to FEDN patients without a suicide attempt. All 5 RBANS subscales (all P <.001) except for the Visuospatial/Constructional index (P >.05) showed significantly lower cognitive performance for FEDN patients than for healthy controls. Among the FEDN patients, the suicide attempters performed better than nonattempters on attention (F-1,F-121 = 5.12, P =.025), with an effect size of 0.49. The following variables were independently associated with suicide attempt as shown by multivariate regression analysis: PANSS negative symptom subscale score (Wald chi(2)(1) = 7.90 P =.005; adjusted OR = 0.807, 95% CI, 0.696-0.936) and Attention (Wald chi(2)(1) = 4.69, P =.03; adjusted OR = 0.957, 95% CI, 0.918-0.997). Conclusions: FEDN patients with schizophrenia attempt suicide more often than the general population. The suicidal patients were more likely to smoke, had lower severity of negative symptoms, and showed better attention than nonsuicidal patients.
关键词Suicide Schizophrenia
2018-07-01
语种英语
DOI10.4088/JCP.17m11797
发表期刊JOURNAL OF CLINICAL PSYCHIATRY
ISSN0160-6689
卷号79期号:4页码:8
收录类别SCI
资助项目Suzhou Key Disciplines for Psychiatry[Szxk201515] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Key Diagnosis and treatment Program of Suzhou[LCZX201515] ; Scientific and Technological Program of Suzhou[SYS201261] ; National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81371477] ; Scientific and Technological Program of Suzhou[SYS201261] ; Key Diagnosis and treatment Program of Suzhou[LCZX201515] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Key Disciplines for Psychiatry[Szxk201515]
出版者PHYSICIANS POSTGRADUATE PRESS
WOS关键词QUALITY-OF-LIFE ; CIGARETTE-SMOKING ; RISK-FACTORS ; FOLLOW-UP ; PSYCHOSIS ; IDEATION ; BEHAVIOR ; NEUROCOGNITION ; METAANALYSIS ; INDIVIDUALS
WOS研究方向Psychology ; Psychiatry
WOS类目Psychology, Clinical ; Psychiatry
WOS记录号WOS:000452890900013
资助机构National Natural Science Foundation of China ; Scientific and Technological Program of Suzhou ; Key Diagnosis and treatment Program of Suzhou ; Suzhou Key Medical Center for Psychiatric Diseases ; Suzhou Key Disciplines for Psychiatry
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被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.psych.ac.cn/handle/311026/27944
专题健康与遗传心理学研究室
通讯作者Zhang, Xiang Yang
作者单位1.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China
2.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Jiangsu, Peoples R China
4.Peking Univ, Beijing Hui Long Guan Hosp, Beijing, Peoples R China
5.Xinxiang Med Univ, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China
6.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China
第一作者单位中国科学院心理研究所
通讯作者单位中国科学院心理研究所
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GB/T 7714
Zhang, Xiang Yang,Du, Xiangdong,Yin, Guangzhong,et al. Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia[J]. JOURNAL OF CLINICAL PSYCHIATRY,2018,79(4):8.
APA Zhang, Xiang Yang.,Du, Xiangdong.,Yin, Guangzhong.,Zhang, Yingyang.,Chen, Dachun.,...&Soares, Jair C..(2018).Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia.JOURNAL OF CLINICAL PSYCHIATRY,79(4),8.
MLA Zhang, Xiang Yang,et al."Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia".JOURNAL OF CLINICAL PSYCHIATRY 79.4(2018):8.
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